Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P(2U) receptors in MDCK-D1 cells: Involvement of MAP kinase-dependent and -independent pathways

Journal of Clinical Investigation

Volumn 99, Issue 4, 1997, Pages 805-814

  Xing, Mingzhao ^a   Firestein, Bonnie L ^a,b   Shen, Gregory H ^a   Insel, Paul A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c San Diego   (United States)

Author keywords

ATP; eicosanoid; epithelial cells; phospholipase; purinergic receptors

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE A2; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PURINE P2Y2 RECEPTOR;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0031036919     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119227     Document Type: Article

References (49)

1. Smith, W.L. 1989. The eicosanoids and their biochemical mechanisms of action. Biochem. J. 259:315-324.
2. Piomelli, D. 1993. Arachidonic acid in cell signaling Curr. Opin. Cell Biol. 5:274-280.
3. 2. J. Biol. Chem. 269:13057-13060.
4. Exton, J.H. 1994. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta. 1212:26-42.
5. 2. Agents Actions. 46 (Suppl.): 65-76.
6. 2 is phosphorylated and activated by MAP kinase. Cell. 72:269-278.
7. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C.J. Biol. Chem. 268:1960-1964.
8. Posada, J., and J.A. Cooper. 1992. Molecular signal integration: interplay between serine, threonine and tyrosine phosphorylation. Mol. Biol. Cell. 3:583-592.
9. Seger, R. and E.G. Krebs. 1995. The MAPK signaling cascade. FASEB J. 9:726-735.
10. 1-adrenergic receptors in Madin-Darby kidney cells. J. Clin. Invest. 97:1302-1310.
11. 2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J. Biol. Chem. 270:2360-2366.
12. 2. J. Biol. Chem. 269:19480-19487.
13. 2 phosphorylation and eicosanoid production by colony-stimulating factor 1. J. Biol. Chem. 269:31693-31700.
14. 2. J. Biol. Chem. 269:3117-3124.
15. 2 is phosphorylated in collagen-and thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase. J. Biol. Chem. 270:25885-25892.
16. 2 in human neutrophils stimulated with tumor necrosis factor α. Biochem. Biophys. Res. Commun. 209:271-278.
17. 2 expressed in insect cells and present in human monocytes. J. Biol. Chem. 271:6987-6997.
18. Wang, Y., M.S. Simonson, J. Pouyssegur, and M.J. Dunn. 1992. Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells. Biochem. J. 287:589-594.
19. Dudley, D.T., L. Pang, S.J. Decker, A.J. Bridges, and A.R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA. 92:7686-7689.
20. 2. J. Biol. Chem. 262:4200-4207.
21. 2is coupled to hormonally regulated release of arachidonic acid. Proc. Natl. Acad. Sci. USA. 89:6147-6151.
22. Bligh, E.G., and W.J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
23. Meier, K.E., D.M. Sperling, and P.A. Insel. 1985. Agonist-mediated regulation of alpha 1-and beta 2-adrenergic receptors in cloned MDCK cells. Am. J. Physiol. 249:C69-C77.
24. Gstraunthaler, G.J.A. 1988. Epithelial cells in tissue culture. Renal Physiol. Biochem. 11:1-42.
25. 2Y purinergic receptor regulation of phospholipases in Madin Darby canine kidney cells. Am. J. Physiol. 271:F610-F618.
26. 2. Biochemistry. 32:5935-5940.
27. 2 by bromoenol lactone and trifluoromethyl ketones. J. Biol. Chem. 270:445-450.
28. de Vries-smits, A.M.M., B.M.T. Burgering, S.J. Leevers, C.J. Marshall, and J.L. Bos. 1992. Involvement of p21 ras in activation of extracellular signal-regulated kinase 2. Nature (London). 357:602-604.
29. Alblas, J., E.J. Van Corven, P.L. Hordijk, G. Milligan, and W.H. Moolenaar. 1993. Gi-mediated activation of the p21 ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts. J. Biol. Chem. 268:22235-22238.
30. Toullec, D., P. Pianetti, H. Coste, P. Bellevergue, T. Grand-Perret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky. 1991. The bisindolylmaleide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266:15771-15781.
31. Wilkinson, S.E., P.J. Parker, and J.S. Nixon. 1993. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294:335-337.
32. Godson, C., K.S. Bell, and P.A. Insel. 1993. Inhibition of expression of protein kinase Cα by antisense cDNA inhibits phorbol ester-mediated arachidonate release. J. Biol. Chem. 268:11946-11950.
33. 2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265:C577-C606.
34. 2-purinergic receptors: subtype-associated signaling responses and structure. Annu. Rev. Pharmacol. Toxicol. 35:541-579.
35. 2y-purinergic receptor. J. Neurochem. 55:1569-1575.
36. 2 activation and exocytosis in HL60 cells and human neutrophils. Biochem. J. 263:715-723.
37. 2u receptor in neuroblastoma glioma (NG108-15) cells. J. Neurochem. 60:1115-1125.
38. 2. Am. J. Physiol. 267:E323-E330.
39. Lazarowski, E.R., R.C. Boucher, and T.K. Harden. 1994. Calcium-dependent release of arachidonic acid in response to purinergic receptor activation in airway epithelium. Am. J. Physiol. 266:C406-C415.
40. 2+ and mitogen-activated protein kinase regulation. J. Biol. Chem. 269:1889-1895.
41. 2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine kidney epithelial cells via a autocrine/paracrine mechanism. J. Biol. Chem. 271:2029-2032.
42. 2. J. Biol. Chem. 268:20713-20716.
43. 1 cells. J. Biol. Chem. 826:21875-21882.
44. 2. J. Biol. Chem. 268:839-844.
45. 2 in human platelets. J. Biol. Chem. 268: 26796-26804.
46. Clerk, A., M.A. Bogoyevitch, M.B. Andersson, and P.H. Sugden. 1994. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. J. Biol. Chem. 269:32848-32857.
47. Clark, K.J. and A.W. Murray. 1995. Evidence that the bradykinin-induced activation of phospholipase D and of the mitogen-activated protein kinase cascade involve different protein kinase C isoforms. J. Biol. Chem. 270:7097-7103.
48. 2 in mouse spleen and macrophage cell line J774. Purification, substrate interaction and phosphorylation by protein kinase C. Eur. J. Biochem. 202:873-880.
49. 1 cells. Am. J. Physiol. In press.