Altered T-cell receptor signaling in the pathogenesis of allergic disease

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 2, 2011, Pages 351-354

  Datta, Shrimati ^a   Milner, Joshua D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

atopy; T cell receptor; TH2

Indexed keywords

CALCIUM; CASPASE RECRUITMENT DOMAIN CONTAINING MEMBRANE ASSOCIATED GUANYLATE KINASE; GAMMA INTERFERON; GUANYLATE KINASE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1; INTERLEUKIN 2; INTERLEUKIN 4; LAT PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE ZAP 70; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ARTICLE; ATOPIC DERMATITIS; ATOPY; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CALCIUM SIGNALING; CD4+ T LYMPHOCYTE; CELL ADHESION; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; GENE MUTATION; GENETIC TRANSCRIPTION; HISTIOCYTOSIS; HUMAN; LYMPHOCYTOSIS; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; GATA3 TRANSCRIPTION FACTOR; HUMANS; HYPERSENSITIVITY; IMMUNOPHENOTYPING; MEMBRANE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH2 CELLS;

EID: 79551475299     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.11.033     Document Type: Article

References (33)

1. Y. Boutin, D. Leitenberg, X. Tao, and K. Bottomly Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets J Immunol 159 1997 5802 5809
2. N.A. Hosken, K. Shibuya, A.W. Heath, K.M. Murphy, and A. O'Garra The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model J Exp Med 182 1995 1579 1584
3. J. Gomez-Rodriguez, N. Sahu, R. Handon, T.S. Davidson, S.M. Anderson, and M.R. Kirby Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase Immunity 31 2009 587 597
4. H. Yamane, J. Zhu, and W.E. Paul Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment J Exp Med 202 2005 793 804
5. S. Steinfelder, J.F. Andersen, J.L. Cannons, C.G. Feng, M. Joshi, and D. Dwyer The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1) J Exp Med 206 2009 1681 1690
6. B. Everts, G. Perona-Wright, H.H. Smits, C.H. Hokke, A.J. van der Ham, and C.M. Fitzsimmons Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses J Exp Med 206 2009 1673 1680
7. D. Levin, R.J. DiPaolo, C. Brinster, M.J. Revilleza, L.F. Boyd, and L. Teyton Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis Eur J Immunol 38 2008 3339 3353
8. R.J. Boyton, N. Zaccai, E.Y. Jones, and D.M. Altmann CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3 J Immunol 168 2002 1018 1027
9. J.D. Milner, N. Fazilleau, M. McHeyzer-Williams, and W. Paul Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production J Immunol 184 2010 6569 6573
10. J.L. Brogdon, D. Leitenberg, and K. Bottomly The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells J Immunol 168 2002 3825 3832
11. P.J. Jorritsma, J.L. Brogdon, and K. Bottomly Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells J Immunol 170 2003 2427 2434
12. J.E. Jun, L.E. Wilson, C.G. Vinuesa, S. Lesage, M. Blery, and L.A. Miosge Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis Immunity 18 2003 751 762
13. H. Hara, T. Wada, C. Bakal, I. Kozieradzki, S. Suzuki, and N. Suzuki The MAGUK family protein CARD11 is essential for lymphocyte activation Immunity 18 2003 763 775
14. T. Jakob, G.V. Kollisch, M. Howaldt, M. Bewersdorff, B. Rathkolb, and M.L. Muller Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis J Allergy Clin Immunol 121 2008 179 184 e7
15. M. Mingueneau, R. Roncagalli, C. Gregoire, A. Kissenpfennig, A. Miazek, and C. Archambaud Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor Immunity 31 2009 197 208
16. C. Picard, S. Dogniaux, K. Chemin, Z. Maciorowski, A. Lim, and F. Mazerolles Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity Eur J Immunol 39 2009 1966 1976
17. O.M. Siggs, L.A. Miosge, A.L. Yates, E.M. Kucharska, D. Sheahan, and T. Brdicka Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions Immunity 27 2007 912 926
18. N. Sakaguchi, T. Takahashi, H. Hata, T. Nomura, T. Tagami, and S. Yamazaki Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice Nature 426 2003 454 460
19. H. Yoshitomi, N. Sakaguchi, K. Kobayashi, G.D. Brown, T. Tagami, and T. Sakihama A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice J Exp Med 201 2005 949 960
20. E. Aguado, S. Richelme, S. Nunez-Cruz, A. Miazek, A.M. Mura, and M. Richelme Induction of T helper type 2 immunity by a point mutation in the LAT adaptor Science 296 2002 2036 2040
21. S. Koonpaew, S. Shen, L. Flowers, and W. Zhang LAT-mediated signaling in CD4+CD25+ regulatory T cell development J Exp Med 203 2006 119 129
22. C.L. Sommers, C.S. Park, J. Lee, C. Feng, C.L. Fuller, and A. Grinberg A LAT mutation that inhibits T cell development yet induces lymphoproliferation Science 296 2002 2040 2043
23. A.M. Thornton, and E.M. Shevach CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 1998 287 296
24. W. Lin, N. Truong, W.J. Grossman, D. Haribhai, C.B. Williams, and J. Wang Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice J Allergy Clin Immunol 116 2005 1106 1115
25. P.L. Poliani, F. Facchetti, M. Ravanini, A.R. Gennery, A. Villa, and C.M. Roifman Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome Blood 114 2009 105 108
26. V. Marrella, P.L. Poliani, A. Casati, F. Rucci, L. Frascoli, and M.L. Gougeon A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome J Clin Invest 117 2007 1260 1269
27. J.D. Milner, J.M. Ward, A. Keane-Myers, and W.E. Paul Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease Proc Natl Acad Sci U S A 104 2007 576 581
28. T. Turul, I. Tezcan, H. Artac, S. de Bruin-Versteeg, B.H. Barendregt, and I. Reisli Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency Eur J Pediatr 168 2009 87 93
29. Q. Zhang, J.C. Davis, I.T. Lamborn, A.F. Freeman, H. Jing, and A.J. Favreau Combined immunodeficiency associated with DOCK8 mutations N Engl J Med 361 2009 2046 2055
30. L. Dupre, A. Aiuti, S. Trifari, S. Martino, P. Saracco, and C. Bordignon Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation Immunity 17 2002 157 166
31. K.L. Randall, T. Lambe, A.L. Johnson, B. Treanor, E. Kucharska, and H. Domaschenz Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production Nat Immunol 10 2009 1283 1291
32. Y. Sasahara, R. Rachid, M.J. Byrne, M.A. de la Fuente, R.T. Abraham, and N. Ramesh Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation Mol Cell 10 2002 1269 1281
33. J. Gerwien, M. Nielsen, T. Labuda, M.H. Nissen, A. Svejgaard, and C. Geisler Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells J Immunol 163 1999 1742 1745