Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling

Virology Journal

Volumn 8, Issue , 2011, Pages

  Pachler, Karin ^a   Vlasak, Reinhard ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; NONSTRUCTURAL PROTEIN 1; RETINOIC ACID INDUCIBLE PROTEIN I; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; LUCIFERASE; VIRULENCE FACTOR; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; INFLUENZA VIRUS C; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIRUS STRAIN; BIOASSAY; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; GENETICS; HUMAN; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; PATHOGENICITY; PROTEIN ANALYSIS; REPORTER GENE;

CERCOPITHECINE HERPESVIRUS 1; INFLUENZA C VIRUS; RNA VIRUSES;

BIOLOGICAL ASSAY; CELL LINE; DEAD-BOX RNA HELICASES; GENES, REPORTER; HUMANS; IMMUNE EVASION; INFLUENZAVIRUS C; INTERFERON-BETA; LUCIFERASES; PROTEIN INTERACTION MAPPING; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

EID: 79251601674     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-8-48     Document Type: Article

References (23)

1. Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez-Sobrido L, Akira S, Gill MA, Garcia-Sastre A, Katze MG, Gale M Jr: Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol 2008, 82:335-45. (Pubitemid 350309149)
2. Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004, 5:730-7. (Pubitemid 39023305)
3. Cui S, Eisenacher K, Kirchhofer A, Brzozka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP: The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell 2008, 29:169-79. (Pubitemid 351172822)
4. Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T: Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell 2008, 29:428-40.
5. Pichlmair A, Schulz O, Tan CP, Naslund TI, Liljestrom P, Weber F, Reis e, Sousa C: RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 2006, 314:997-1001.
6. Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 2007, 446:916-920. (Pubitemid 46633167)
7. Albrecht RA, Garcia-Sastre A: Suppression of innate immunity by Orthomyxoviruses. In Cellular signaling and innate immune response to RNA virus infections. Edited by: Brasier AR, Garcia-Sastre A. Washington, D.C.: ASM Press; 267-86.
8. Guo Z, Chen LM, Zeng H, Gomez JA, Plowden J, Fujita T, Katz JM, Donis RO, Sambhara S: NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I. Am J Respir Cell Mol Biol 2007, 36:263-9. (Pubitemid 46365276)
9. Mibayashi M, Martinez-Sobrido L, Loo YM, Cardenas WB, Gale M Jr, Garcia- Sastre A: Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 2007, 81:514-24. (Pubitemid 46067878)
10. Opitz B, Rejaibi A, Dauber B, Eckhard J, Vinzing M, Schmeck B, Hippenstiel S, Suttorp N, Wolff T: IFNβ induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol 2007, 9:930-8. (Pubitemid 46394904)
11. Hatada E, Takizawa T, Fukuda R: Specific binding of influenza A virus NS1 protein to the virus minus-sense RNA in vitro. J Gen Virol 1992, 73:17-25.
12. Hatada E, Fukuda R: Binding of influenza A virus NS1 protein to dsRNA in vitro. J Gen Virol 1992, 73:3325-3329. (Pubitemid 23014192)
13. Donelan NR, Basler CF, Garcia-Sastre A: A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. J Virol 2003, 77:13257-13266. (Pubitemid 37494321)
14. Ferko B, Stasakova J, Romanova J, Kittel C, Sereinig S, Katinger H, Egorov A: Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J Virol 2004, 78:13037-13045. (Pubitemid 39507811)
15. Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, Garcia-Sastre A: Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 2009, 5:439-49.
16. Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, Garcia-Sastre A: Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 2000, 74:7989-96. (Pubitemid 30641643)
17. Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, Garcia-Sastre A: Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J Virol 2000, 74:11566-73. (Pubitemid 32222305)
18. Ludwig S, Wang X, Ehrhardt C, Zheng H, Donelan N, Planz O, Pleschka S, Garcia-Sastre A, Heins G, Wolff T: The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors. J Virol 2002, 76:11166-71. (Pubitemid 35176236)
19. Alamgir AS, Matsuzaki Y, Hongo S, Tsuchiya E, Sugawara K, Muraki Y, Nakamura K: Phylogenetic analysis of influenza C virus nonstructural (NS) protein genes and identification of the NS2 protein. J Gen Virol 2000, 81:1933-40. (Pubitemid 30599173)
20. Pachler K, Mayr J, Vlasak R: A seven plasmid-based system for rescue of influenza C virus. J Mol Genet Med 2010, 4:239-246.
21. Muraki Y, Furukawa T, Kohno Y, Matsuzaki Y, Takashita E, Sugawara K, Hongo S: Influenza C virus NS1 protein upregulates the splicing of viral mRNAs. J Virol 2010, 84:1957-66.
22. Wang X, Li M, Zheng H, Muster T, Palese P, Beg AA, Garcia-Sastre A: Influenza A Virus NS1 Protein Prevents Activation of NF-kappa B and Induction of Alpha/Beta Interferon. J Virol 2000, 74:11566-11573. (Pubitemid 32222305)
23. Donelan NR, Dauber B, Wang X, Basler CF, Wolff T, Garcia-Sastre A: The Nand C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation. J Virol 2004, 78:11574-82. (Pubitemid 39390743)