-
1
-
-
77949417518
-
Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity
-
1:CAS:528:DC%2BC3cXit1Ogt7o%3D 10.1016/j.taap.2009.11.019 19932708
-
RD Beger J Sun LK Schnackenberg 2010 Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity Toxicol Appl Pharmacol 243 154 166 1:CAS:528:DC%2BC3cXit1Ogt7o%3D 10.1016/j.taap.2009. 11.019 19932708
-
(2010)
Toxicol Appl Pharmacol
, vol.243
, pp. 154-166
-
-
Beger, R.D.1
Sun, J.2
Schnackenberg, L.K.3
-
2
-
-
53349117682
-
Metabolomics: Biochemistry's new look
-
1:CAS:528:DC%2BD1cXhtF2hsb%2FK 10.1038/455697a 18833281
-
N Blow 2008 Metabolomics: biochemistry's new look Nature 455 697 700 1:CAS:528:DC%2BD1cXhtF2hsb%2FK 10.1038/455697a 18833281
-
(2008)
Nature
, vol.455
, pp. 697-700
-
-
Blow, N.1
-
3
-
-
77950486294
-
Gene array screening for identification of drugs with low levels of adverse side effects
-
1:CAS:528:DC%2BC3cXjtFOhsb4%3D 10.1007/s00204-010-0534-8 20229237
-
HM Bolt R Marchan JG Hengstler 2010 Gene array screening for identification of drugs with low levels of adverse side effects Arch Toxicol 84 253 254 1:CAS:528:DC%2BC3cXjtFOhsb4%3D 10.1007/s00204-010-0534-8 20229237
-
(2010)
Arch Toxicol
, vol.84
, pp. 253-254
-
-
Bolt, H.M.1
Marchan, R.2
Hengstler, J.G.3
-
4
-
-
33750289167
-
Influence of CYP2D6 polymorphism on 3, 4-methylenedioxymethamphetamine ('Ecstasy') cytotoxicity
-
1:CAS:528:DC%2BD28XhtVynsLnL 10.1097/01.fpc.0000230419.05221.fc 17047487
-
H Carmo M Brulport M Hermes F Oesch R Silva LM Ferreira PS Branco D Boer F Remião F Carvalho MR Schön N Krebsfaenger J Doehmer L Bastos Mde JG Hengstler 2006 Influence of CYP2D6 polymorphism on 3, 4- methylenedioxymethamphetamine ('Ecstasy') cytotoxicity Pharmacogenet Genomics 16 789 799 1:CAS:528:DC%2BD28XhtVynsLnL 10.1097/01.fpc.0000230419.05221.fc 17047487
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 789-799
-
-
Carmo, H.1
Brulport, M.2
Hermes, M.3
Oesch, F.4
Silva, R.5
Ferreira, L.M.6
Branco, P.S.7
Boer, D.8
Remião, F.9
Carvalho, F.10
Schön, M.R.11
Krebsfaenger, N.12
Doehmer, J.13
Bastos Mde, L.14
Hengstler, J.G.15
-
5
-
-
33845580694
-
CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)
-
1:CAS:528:DC%2BD2sXht1arsQ%3D%3D 10.1016/j.tox.2006.10.024 17156908
-
H Carmo M Brulport M Hermes F Oesch D de Boer F Remião F Carvalho MR Schön N Krebsfaenger J Doehmer L Bastos Mde JG Hengstler 2007 CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA) Toxicology 229 3 236 244 1:CAS:528:DC%2BD2sXht1arsQ%3D%3D 10.1016/j.tox.2006.10. 024 17156908
-
(2007)
Toxicology
, vol.229
, Issue.3
, pp. 236-244
-
-
Carmo, H.1
Brulport, M.2
Hermes, M.3
Oesch, F.4
De Boer, D.5
Remião, F.6
Carvalho, F.7
Schön, M.R.8
Krebsfaenger, N.9
Doehmer, J.10
Bastos Mde, L.11
Hengstler, J.G.12
-
6
-
-
68149162196
-
D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats
-
Davidson ME, Kerepesi LA, Soto A, Chan VT (2009) D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats. Arch Toxicol 83:747-762
-
(2009)
Arch Toxicol
, vol.83
, pp. 747-762
-
-
Davidson, M.E.1
Kerepesi, L.A.2
Soto, A.3
Chan, V.T.4
-
7
-
-
36049005565
-
Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian population
-
1:CAS:528:DC%2BD2sXht1ylurbE 10.1097/JOM.0b013e3181565d29 17993927
-
SS Devi AR Biswas RA Biswas N Vinayagamoorthy K Krishnamurthi VM Shinde JG Hengstler M Hermes T Chakrabarti 2007 Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian population J Occup Environ Med 49 1228 1234 1:CAS:528:DC%2BD2sXht1ylurbE 10.1097/JOM.0b013e3181565d29 17993927
-
(2007)
J Occup Environ Med
, vol.49
, pp. 1228-1234
-
-
Devi, S.S.1
Biswas, A.R.2
Biswas, R.A.3
Vinayagamoorthy, N.4
Krishnamurthi, K.5
Shinde, V.M.6
Hengstler, J.G.7
Hermes, M.8
Chakrabarti, T.9
-
8
-
-
36348960223
-
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The consortium on metabonomic toxicology screening approach
-
1:CAS:528:DC%2BD2sXhtFWgu77N 10.1021/pr0703021 17915905
-
TM Ebbels HC Keun OP Beckonert ME Bollard JC Lindon E Holmes JK Nicholson 2007 Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach J Proteome Res 6 4407 4422 1:CAS:528:DC%2BD2sXhtFWgu77N 10.1021/pr0703021 17915905
-
(2007)
J Proteome Res
, vol.6
, pp. 4407-4422
-
-
Ebbels, T.M.1
Keun, H.C.2
Beckonert, O.P.3
Bollard, M.E.4
Lindon, J.C.5
Holmes, E.6
Nicholson, J.K.7
-
9
-
-
77957803158
-
Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR
-
1:CAS:528:DC%2BC3cXosV2qtbs%3D 10.1007/s00204-010-0572-2 20614104
-
CR Elcombe BM Elcombe JR Foster DG Farrar R Jung SC Chang GL Kennedy JL Butenhoff 2010 Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR Arch Toxicol 84 787 798 1:CAS:528:DC%2BC3cXosV2qtbs%3D 10.1007/s00204-010-0572-2 20614104
-
(2010)
Arch Toxicol
, vol.84
, pp. 787-798
-
-
Elcombe, C.R.1
Elcombe, B.M.2
Foster, J.R.3
Farrar, D.G.4
Jung, R.5
Chang, S.C.6
Kennedy, G.L.7
Butenhoff, J.L.8
-
10
-
-
48749124037
-
Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors
-
1:CAS:528:DC%2BD1cXpt12rs7k%3D 10.1007/s00204-008-0331-9 18654764
-
F Glahn W Schmidt-Heck S Zellmer R Guthke J Wiese K Golka R Hergenröder GH Degen T Lehmann M Hermes W Schormann M Brulport A Bauer E Bedawy R Gebhardt JG Hengstler H Foth 2008 Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors Arch Toxicol 82 513 524 1:CAS:528:DC%2BD1cXpt12rs7k%3D 10.1007/s00204-008-0331-9 18654764
-
(2008)
Arch Toxicol
, vol.82
, pp. 513-524
-
-
Glahn, F.1
Schmidt-Heck, W.2
Zellmer, S.3
Guthke, R.4
Wiese, J.5
Golka, K.6
Hergenröder, R.7
Degen, G.H.8
Lehmann, T.9
Hermes, M.10
Schormann, W.11
Brulport, M.12
Bauer, A.13
Bedawy, E.14
Gebhardt, R.15
Hengstler, J.G.16
Foth, H.17
-
11
-
-
67650999336
-
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis
-
1:CAS:528:DC%2BD1MXotVCmurw%3D 10.1002/hep.22880 19274752
-
P Godoy JG Hengstler I Ilkavets C Meyer A Bachmann A Müller G Tuschl SO Mueller S Dooley 2009 Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis Hepatology 49 2031 2043 1:CAS:528:DC%2BD1MXotVCmurw%3D 10.1002/hep.22880 19274752
-
(2009)
Hepatology
, vol.49
, pp. 2031-2043
-
-
Godoy, P.1
Hengstler, J.G.2
Ilkavets, I.3
Meyer, C.4
Bachmann, A.5
Müller, A.6
Tuschl, G.7
Mueller, S.O.8
Dooley, S.9
-
12
-
-
33847018050
-
Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
-
1:CAS:528:DC%2BD2sXjsF2ntrw%3D 10.1080/03602530601093489 17364884
-
NJ Hewitt MJ Lechón JB Houston D Hallifax HS Brown P Maurel JG Kenna L Gustavsson C Lohmann C Skonberg A Guillouzo G Tuschl AP Li E LeCluyse GM Groothuis JG Hengstler 2007 Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies Drug Metab Rev 39 159 234 1:CAS:528:DC%2BD2sXjsF2ntrw%3D 10.1080/03602530601093489 17364884
-
(2007)
Drug Metab Rev
, vol.39
, pp. 159-234
-
-
Hewitt, N.J.1
Lechón, M.J.2
Houston, J.B.3
Hallifax, D.4
Brown, H.S.5
Maurel, P.6
Kenna, J.G.7
Gustavsson, L.8
Lohmann, C.9
Skonberg, C.10
Guillouzo, A.11
Tuschl, G.12
Li, A.P.13
Lecluyse, E.14
Groothuis, G.M.15
Hengstler, J.G.16
-
13
-
-
77953771023
-
Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
-
1:CAS:528:DC%2BC3cXnvV2is7o%3D 10.1073/pnas.0909374107 20484673
-
S Hoehme M Brulport A Bauer E Bedawy W Schormann M Hermes V Puppe R Gebhardt S Zellmer M Schwarz E Bockamp T Timmel JG Hengstler D Drasdo 2010 Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration Proc Natl Acad Sci USA 107 10371 10376 1:CAS:528:DC%2BC3cXnvV2is7o%3D 10.1073/pnas.0909374107 20484673
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10371-10376
-
-
Hoehme, S.1
Brulport, M.2
Bauer, A.3
Bedawy, E.4
Schormann, W.5
Hermes, M.6
Puppe, V.7
Gebhardt, R.8
Zellmer, S.9
Schwarz, M.10
Bockamp, E.11
Timmel, T.12
Hengstler, J.G.13
Drasdo, D.14
-
16
-
-
77956225641
-
Simultaneous gene expression signature of heart and peripheral blood mononuclear cells in astemizole-treated rats
-
1:CAS:528:DC%2BC3cXjtVWrsL0%3D 10.1007/s00204-010-0529-5 20221588
-
EH Lee JH Oh HJ Park DG Kim JH Lee CY Kim MS Kwon S Yoon 2010 Simultaneous gene expression signature of heart and peripheral blood mononuclear cells in astemizole-treated rats Arch Toxicol 84 609 618 1:CAS:528: DC%2BC3cXjtVWrsL0%3D 10.1007/s00204-010-0529-5 20221588
-
(2010)
Arch Toxicol
, vol.84
, pp. 609-618
-
-
Lee, E.H.1
Oh, J.H.2
Park, H.J.3
Kim, D.G.4
Lee, J.H.5
Kim, C.Y.6
Kwon, M.S.7
Yoon, S.8
-
17
-
-
79251595354
-
The role of metabolites and metabolomics in clinically applicable biomarkers of disease
-
this issue. doi: 10.1007/s00204-010-0609-6
-
Mamas M, Dunn WB, Neyses L, Goodacre R (2010) The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol, this issue. doi: 10.1007/s00204-010-0609-6
-
(2010)
Arch Toxicol
-
-
Mamas, M.1
Dunn, W.B.2
Neyses, L.3
Goodacre, R.4
-
18
-
-
68749113736
-
3-Hydroxybenzo(a)pyrene as a biomarker of dermal exposure to benzo(a)pyrene
-
1:CAS:528:DC%2BD1MXntF2mtr0%3D 10.1007/s00204-009-0440-0 19526226
-
JP Payan M Lafontaine P Simon F Marquet C Champmartin-Gendre D Beydon L Wathier E Ferrari 2009 3-Hydroxybenzo(a)pyrene as a biomarker of dermal exposure to benzo(a)pyrene Arch Toxicol 83 873 883 1:CAS:528:DC%2BD1MXntF2mtr0%3D 10.1007/s00204-009-0440-0 19526226
-
(2009)
Arch Toxicol
, vol.83
, pp. 873-883
-
-
Payan, J.P.1
Lafontaine, M.2
Simon, P.3
Marquet, F.4
Champmartin-Gendre, C.5
Beydon, D.6
Wathier, L.7
Ferrari, E.8
-
19
-
-
77952552360
-
Dectin-1 and inflammation-associated gene transcription and expression in mouse lungs by a toxic (1, 3)-beta-D: Glucan
-
1:CAS:528:DC%2BD1MXhtl2jtb3N 10.1007/s00204-009-0481-4 19904525
-
TG Rand M Sun A Gilyan J Downey JD Miller 2010 Dectin-1 and inflammation-associated gene transcription and expression in mouse lungs by a toxic (1, 3)-beta-D: glucan Arch Toxicol 84 205 220 1:CAS:528:DC%2BD1MXhtl2jtb3N 10.1007/s00204-009-0481-4 19904525
-
(2010)
Arch Toxicol
, vol.84
, pp. 205-220
-
-
Rand, T.G.1
Sun, M.2
Gilyan, A.3
Downey, J.4
Miller, J.D.5
-
20
-
-
76749097989
-
Biomarkers of organophosphorus nerve agent exposure: Comparison of phosphylated butyrylcholinesterase and phosphylated albumin after oxime therapy
-
1:CAS:528:DC%2BD1MXhtlanu7fO 10.1007/s00204-009-0473-4 19862504
-
RW Read JR Riches JA Stevens SJ Stubbs RM Black 2010 Biomarkers of organophosphorus nerve agent exposure: comparison of phosphylated butyrylcholinesterase and phosphylated albumin after oxime therapy Arch Toxicol 84 25 36 1:CAS:528:DC%2BD1MXhtlanu7fO 10.1007/s00204-009-0473-4 19862504
-
(2010)
Arch Toxicol
, vol.84
, pp. 25-36
-
-
Read, R.W.1
Riches, J.R.2
Stevens, J.A.3
Stubbs, S.J.4
Black, R.M.5
-
21
-
-
59849100943
-
Primary rat hepatocytes as in vitro system for gene expression studies: Comparison of sandwich, Matrigel and 2D cultures
-
1:CAS:528:DC%2BD1cXhtlCju7zO 10.1007/s00204-008-0375-x 18987846
-
M Schug T Heise A Bauer D Storm M Blaszkewicz E Bedawy M Brulport B Geppert M Hermes W Föllmann K Rapp L Maccoux W Schormann KE Appel A Oberemm U Gundert-Remy JG Hengstler 2008 Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, Matrigel and 2D cultures Arch Toxicol 82 923 931 1:CAS:528:DC%2BD1cXhtlCju7zO 10.1007/s00204-008-0375-x 18987846
-
(2008)
Arch Toxicol
, vol.82
, pp. 923-931
-
-
Schug, M.1
Heise, T.2
Bauer, A.3
Storm, D.4
Blaszkewicz, M.5
Bedawy, E.6
Brulport, M.7
Geppert, B.8
Hermes, M.9
Föllmann, W.10
Rapp, K.11
MacCoux, L.12
Schormann, W.13
Appel, K.E.14
Oberemm, A.15
Gundert-Remy, U.16
Hengstler, J.G.17
-
22
-
-
77950467100
-
Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls
-
1:CAS:528:DC%2BD1MXhsFOhtb%2FP 10.1007/s00204-009-0493-0 20020106
-
M Shimada S Kameo N Sugawara K Yaginuma-Sakurai N Kurokawa S Mizukami-Murata K Nakai H Iwahashi H Satoh 2010 Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls Arch Toxicol 84 271 286 1:CAS:528:DC%2BD1MXhsFOhtb%2FP 10.1007/s00204-009-0493-0 20020106
-
(2010)
Arch Toxicol
, vol.84
, pp. 271-286
-
-
Shimada, M.1
Kameo, S.2
Sugawara, N.3
Yaginuma-Sakurai, K.4
Kurokawa, N.5
Mizukami-Murata, S.6
Nakai, K.7
Iwahashi, H.8
Satoh, H.9
-
23
-
-
64249122641
-
Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development
-
1:CAS:528:DC%2BD1MXktVKgtr8%3D 10.1007/s00204-008-0346-2 18668222
-
AR Stapleton VT Chan 2009 Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development Arch Toxicol 83 319 333 1:CAS:528:DC%2BD1MXktVKgtr8%3D 10.1007/s00204-008-0346-2 18668222
-
(2009)
Arch Toxicol
, vol.83
, pp. 319-333
-
-
Stapleton, A.R.1
Chan, V.T.2
|