Simultaneous gene expression signature of heart and peripheral blood mononuclear cells in astemizole-treated rats

Archives of Toxicology

Volumn 84, Issue 8, 2010, Pages 609-618

  Lee, Eun Hee ^a,b   Oh, Jung Hwa ^a   Park, Han Jin ^a   Kim, Do Geun ^a   Lee, Jong Hwa ^a   Kim, Choong Yong ^a   Kwon, Myung Sang ^a,c   Yoon, Seokjoo ^a,b  

^a Korea Institute of Toxicology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

Astemizole; Cardiotoxicity; Gene expression profiling; Ventricular tachycardia

Indexed keywords

ASTEMIZOLE; BIOLOGICAL MARKER; HEAT SHOCK PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CARDIOTOXICITY; CELL HYPOXIA; CELLULAR IMMUNITY; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE MARKER; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; ENERGY METABOLISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HEART VENTRICLE TACHYCARDIA; INFLAMMATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TORSADE DES POINTES; UPREGULATION;

ANIMALS; ASTEMIZOLE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; LEUKOCYTES, MONONUCLEAR; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 77956225641     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0529-5     Document Type: Article

References (43)

1. FJ Abajo LAG Rodriguez 1999 Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs Br J Clin Pharmacol 47 307 313 10.1046/j.1365-2125.1999.00885.x 10215756
2. P Bianchi O Kunduzova E Masini C Cambon D Bani L Raimondi MH Seguelas S Nistri W Colucci N Leducq A Parini 2005 Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury Circulation 112 3297 3305 10.1161/CIRCULATIONAHA. 104.528133 1:CAS:528:DC%2BD2MXht1arsrnP 16286591
3. RO Bishop PL Gaudry 1989 Prolonged Q-T interval following astemizole overdose Arch Emerg Med 6 63 65 1:STN:280:DyaL1M3ivVemtg%3D%3D 2565725
4. CI Burul M Morad 1995 Regulation of potassium channels by nonsedating antihistamines Circulation 91 2220 2225
5. PR Bushel AN Heinloth J Li L Huang JW Chou GA Boorman DE Malarkey CD Houle SM Ward RE Wilson RD Fannin MW Russo PB Watkins RW Tennant RS Paules 2007 Blood gene expression signatures predict exposure levels PNAS 104 18211 18216 10.1073/pnas.0706987104 1:CAS:528:DC%2BD2sXhsVejtLbL 17984051
6. TM Craft 1986 Torsades de pointes after astemizole overdose Br Med J 292 660 10.1136/bmj.292.6521.660 1:STN:280:DyaL287jt1GlsQ%3D%3D
7. NC Danbolt 2001 Glutamate uptake Prog Neurobiol 65 1 105 10.1016/S0301-0082(00)00067-8 1:CAS:528:DC%2BD3MXjsFWns74%3D 11369436
8. BR Danielsson C Danielsson MF Nilsson 2007 Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs Reprod Toxicol 24 42 56 10.1016/j.reprotox.2007.04.005 1:CAS:528:DC%2BD2sXnslWit7g%3D 17570632
9. F De Clerck A Van de Water J D'Aubioul HR Lu K Van Rossem A Hermans K Van Ammel 2002 In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical Fund Clin Pharmacol 16 125 140 10.1046/j.1472-8206.2002.00081.x
10. S Debey T Zander B Brors A Popov R Eils JL Schultze 2006 A highly standardized, robust, and cost-effective method for genome-wide transcriptome analysis of peripheral blood applicable to large-scale clinical trials Genomics 87 653 664 10.1016/j.ygeno.2005.11.010 1:CAS:528:DC%2BD28XktVWks74%3D 16387473
11. C Debouck PN Goodfellow 1999 DNA microarrays in drug discovery and development Nat Genet Suppl 21 48 50 10.1038/4475 1:CAS:528:DyaK1MXltlWhtQ%3D%3D
12. LM Dinkelborg RKH Kinne MK Grieshaber 1996 Transport and metabolism of L-glutamate during oxygenation, anoxia, and reoxygenation of rat cardiac myocytes Am J Physiol 270 H1825 H1832 1:CAS:528:DyaK28Xjt1Ogs78%3D 8928892
13. JH Doroshow GY Locker CE Myers 1980 Enzymatic defenses of the mouse heart against reactive oxygen metabolites J Clin Invest 65 128 135 10.1172/JCI109642 1:CAS:528:DyaL3cXovVyruw%3D%3D 7350193
14. DE Dostal KM Baker 1992 Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart: mediation by the AT1 receptor Am J Hypertens 5 276 280 1:CAS:528:DyaK38Xkt1Wisbw%3D 1533768
15. Z Gaoa H Xub D DiSilvestrec VL Halperinc R Tuninc Y Tianc W Yub RL Winslowa GF Tomasellia 2006 Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure J Mol Cell Cardiol 40 76 86 10.1016/j.yjmcc.2005.08.002
16. RF García-Ferreiro D Kerschensteiner F Major F Monje W Stühmer LA Pardo 2004 Mechanism of block of hEag1K+ channels by imipramine and astemizole J Gen Physiol 124 301 317 10.1085/jgp.200409041 15365094
17. C Grond-Ginsbach M Hummel T Wiest S Horstmann K Pfleger M Hergenhahn M Hollstein U Mansmann AJ Grau S Wagner 2008 Gene expression in human peripheral blood mononuclear cells upon acute ischemic stroke J Neurol 255 723 731 10.1007/s00415-008-0784-z 1:STN:280:DC%2BD1czjvVGlsA%3D%3D 18465111
18. BD Guth S Germeyer W Kolb M Markert 2004 Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization J Pharmacol Toxicol Methods 49 159 169 10.1016/j.vascn.2004.02.006 1:CAS:528:DC%2BD2cXksVCjtb8%3D 15172012
19. M Han CT Liew HW Zhang S Chao R Zheng KT Yip ZY Song HM Li XP Geng LX Zhu JJ Lin KW Marshall CC Liew 2008 Novel blood-based, five-gene biomarker set for the detection of colorectal cancer Clin Cancer Res 14 455 460 10.1158/1078-0432.CCR-07-1801 1:CAS:528:DC%2BD1cXhtVKiur8%3D 18203981
20. B Hirakawa BA Jessen O Illanes A de Peyster T McDermott GJ Stevens 2008 Toxicogenomic analysis of cardiotoxicity in rats Genomics Insights 1 3 13 1:CAS:528:DC%2BD1cXhtV2ht7zO
21. PA Horwitz EJ Tsai ME Putt JM Gilmore JJ Lepore MS Parmacek AC Kao SS Desai LR Goldberg SC Brozena ML Jessup JA Epstein TP Cappola 2004 Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression Circulation 110 3815 3821 10.1161/01.CIR. 0000150539.72783.BF 1:CAS:528:DC%2BD2MXotFensw%3D%3D 15583081
22. C Juel 2009 Na+-K+-ATPase in rat skeletal muscle: muscle fiber-specific differences in exercise-induced changes in ion affinity and maximal activity Am J Physiol Regul Integr Comp Physiol 296 125 132
23. MM Kittleson JM Hare 2005 Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular disease Trends Cardiovasc Med 15 130 138 10.1016/j.tcm.2005.05.007 1:CAS:528: DC%2BD2MXos1aitbc%3D 16099376
24. CC Liew VJ Dzau 2004 Molecular genetics and genomics of heart failure Nat Rev Genet 5 811 825 10.1038/nrg1470 1:CAS:528:DC%2BD2cXptFenurs%3D 15520791
25. CC Liew J Ma HG Tang R Zheng AA Dempsey 2006 The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool J Lab Clin Med 147 126 132 10.1016/j.lab.2005.10.005 1:CAS:528: DC%2BD28XhvVWru7o%3D 16503242
26. S Mohr CC Liew 2007 The peripheral-blood transcriptome: new insights into disease and risk assessment Trends Mol Med 13 422 432 10.1016/j.molmed.2007.08. 003 1:CAS:528:DC%2BD2sXhtF2hs7rO 17919976
27. BP Monahan CL Ferguson ES Killeavy BK Lloyd J Troy LR Cantilena Jr 1990 Torsade de pointes occurring in association with terfenadine use JAMA 264 2788 2790 10.1001/jama.264.21.2788 1:STN:280:DyaK3M%2FjvFOktg%3D%3D 1977935
28. L Nanni C Romualdi A Maseri G Lanfranchi 2006 Differential gene expression profiling in genetic and multifactorial cardiovascular diseases J Mol Cell Cardiol 41 934 948 10.1016/j.yjmcc.2006.08.009 1:CAS:528: DC%2BD2sXisFartQ%3D%3D 17020763
29. I Osman DF Bajorin TT Sun H Zhong D Douglas J Scattergood R Zheng M Han KW Marshall CC Liew 2006 Novel blood biomarkers of human urinary bladder cancer Clin Cancer Res 12 3374 3380 10.1158/1078-0432.CCR-05-2081 1:CAS:528: DC%2BD28XltFyis70%3D 16740760
30. HJ Park JW Seo JH Oh SH Lee EH Lee CY Kim SJ Yoon 2008 Gene expression changes in peripheral blood mononuclear cells from Cynomolgus monkeys following astemizole exposure Mol Cell Toxicol 4 323 330
31. MA Pearen SA Myers S Raichur JG Ryall GS Lynch GE Muscat 2008 The orphan nuclear receptor, NOR-1, a target of β-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle Endocrinology 149 2853 2865 10.1210/en.2007-1202 1:CAS:528:DC%2BD1cXms1ent7o%3D 18325999
32. ST Pleger P Most HA Katus 2007 S100 proteins: a missing piece in the puzzle of heart failure? Cardiovasc Res 75 1 2 10.1016/j.cardiores.2007.05.009 1:CAS:528:DC%2BD2sXmt1ynt7w%3D 17531210
33. JC Rockett ME Burczynski AJ Fornace Jr PC Herrmann SA Krawetz DJ Dix 2004 Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells Toxicol Appl Pharmacol 194 189 199 10.1016/j.taap.2003.09.005 1:CAS:528:DC%2BD2cXkvFyhsw%3D%3D 14736499
34. DL Rollins CR Killingsworth GP Walcott RK Justice RE Ideker WM Smith 2000 A telemetry system for the study of spontaneous cardiac arrhythmias IEEE Trans Biomed Eng 47 887 892 10.1109/10.846682 1:STN:280:DC%2BD3cvitVGkuw%3D%3D 10916259
35. AA Salah JD St. Lous GC Hughes JE Lowe 1999 Metabolic changes in the normal and hypoxic neonatal myocardium Ann NY Acad Sci 874 254 261 10.1111/j.1749-6632.1999.tb09240.x
36. JJ Salata NK Jurkiewicz AA Wallace RF Stupienski 3rd PJ Guinosso Jr JJ Lynch Jr 1995 Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine Circ Res 76 110 119 1:CAS:528:DyaK2MXkt1Sjsbs%3D 8001268
37. H Suessbrich S Waldegger F Lang AE Busch 1996 Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole FEBS Lett 385 77 80 10.1016/0014-5793(96)00355-9 1:CAS:528:DyaK28Xisl2ks7Y%3D 8641472
38. L Suter LE Babiss EB Wheeldon 2004 Toxicogenomics in predictive toxicology in drug development Chem Biol 11 161 171 1:CAS:528: DC%2BD2cXhsleksr0%3D 15123278
39. YLA Tang BJ Aronow FR Sharp 2001 Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease Ann Neurol 50 699 707 10.1002/ana.10042 1:CAS:528:DC%2BD38Xhs1KnsA%3D%3D 11761467
40. DM van Leeuwen RWH Gottschalk G Schoeters NA van Larebeke V Nelen WF Baeyens JCS Kleinjans JHM van Delft 2008 Transcriptome analysis in peripheral blood of humans exposed to environmental carcinogens: a promising new biomarker in environmental health studies Environ Health Persp 116 1519 1525 10.1289/ehp.11401
41. V Vorperian Z Zhou S Mohammad TJ Hoon C Studenik CT January 1996 Torsade-de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole JACC 28 1556 1561 1:CAS:528:DyaK28XntlKjsbs%3D 8917271
42. EJ Wang RD Snyder MR Fielden RJ Smith YZ Gua 2008 Validation of putative genomic biomarkers of nephrotoxicity in rats Toxicology 246 91 100 10.1016/j.tox.2007.12.031 1:CAS:528:DC%2BD1cXjtlSrt78%3D 18289764
43. Z Zhou VP Vorperinan Q Gong S Zang CT January 1999 Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole J Cardiovasc Electrophysiol 10 836 843 10.1111/j.1540-8167.1999.tb00264.x 1:STN:280:DyaK1MzgtlCitg%3D%3D 10376921