Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

Immunology

Volumn 120, Issue 2, 2007, Pages 192-206

  Derrick, Steven C ^a   Evering, Teresa H ^b   Sambandamurthy, Vasan K ^b,c   Jalapathy, Kripa V ^b   Hsu, Tsungda ^b   Chen, Bing ^b,c   Chen, Mei ^b   Russell, Robert G ^d   Junqueira Kipnis, Ana Paula ^e   Orme, Ian M ^e   Porcelli, Steven A ^b   Jacobs Jr , William R ^b,c   Morris, Sheldon L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Cytokines; T cells; Tuberculosis; Vaccine

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MYCOBACTERIUM VACCINE; T LYMPHOCYTE RECEPTOR;

ACTIVE IMMUNIZATION; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIUM MUTANT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; HISTOCOMPATIBILITY COMPLEX; IMMUNE DEFICIENCY; IMMUNE RESPONSE; LUNG; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; T LYMPHOCYTE; TUBERCULOSIS; VACCINATION; WILD TYPE;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; GENE EXPRESSION REGULATION; IMMUNITY, CELLULAR; IMMUNOCOMPROMISED HOST; INTERFERON TYPE II; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, MESSENGER; TUBERCULOSIS VACCINES; TUBERCULOSIS, PULMONARY; VACCINATION; VACCINES, ATTENUATED;

EID: 33846010733     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2006.02491.x     Document Type: Article

References (48)

1. Dye C, Scheele S, Dolin P, Pathania V, Raviglone MC. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 1999; 282:677-86.
2. McShane H. Co-infection with HIV and TB. Double trouble. Int J STD AIDS 2005; 16:95-100.
3. Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 2003; 163:1009-20.
4. Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C. Tuberculosis. Lancet 2003; 362:887-99.
5. World Health Organization. Fact Sheet no. 104. 2005: http://www.who.int/mediacentre/factsheets.
6. Kamath AT, Fruth U, Brennan MJ, et al. New live mycobacterial vaccines: the Geneva consensus on essential steps toward clinical development. Vaccine 2005; 23:3753-61.
7. Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs WR. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med 2002; 8:1171-4.
8. Sambandamurthy VK, Derrick SC, Jalapathy KV, Chen B, Russell RG, Morris SL, Jacobs WR. Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis. Infect Immun 2005; 73:1196-203.
9. Sampson SL, Dascher CC, Sambandamurthy VK, Russell RG, Jacobs WR, Bloom BR, Hondalus MK. Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs. Infect Immun 2004; 72:3031-7.
10. Behr MA, Wilson MA, Gill WP, Salamon H, Schoolnik GK, Rane S, Small PM. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 1999; 284:1520-3.
11. Mostovy S, Cousins D, Brinkman J, Aranaz A, Behr MA. Genomic deletions suggest a phylogeny for the Mycobacterium tuberculosis complex. J Infect Dis 2002; 186:74-80.
12. Hsu T, Hingley-Wilson SM, Chen B, et al. The primary mechanism of attenuation of BCG is a loss of secreted lytic function required for invasion. Proc Natl Acad Sci USA 2003; 100:12420-5.
13. Lewis KN, Liao R, Guinn KM, Hickey MJ, Smith S, Behr MA, Sherman DR. Deletion of RD1 from Mycobacterium tuberculosis mimics Bacille Calmette-Guérin attenuation. J Infect Dis 2003; 187:117-23.
14. Pym AS, Brodin P, Brosch R, Huerre M, Cole ST. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti. Mol Microbiol 2002; 46:709-17.
15. Sambandamurthy VK, Derrick SC, Hsu T, et al. Mycobacterium tuberculosis ΔRDI ΔpanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompressed mice against experimental tuberculosis. Vaccine 2006; 24:6309-20.
16. Yee D, Rhinehart-Jones TR, Elkins KL. Loss of either CD4+ or CD8+ T cells does not affect the magnitude of the protective immunity to an intracellular pathogen, Francisella tularenisis LVS. J Immunol 1996; 158:1217-5048.
17. - double negative T cells bearing αβ antigen receptor from conventional ones with either CD4 or CD8 in murine lung. Immunol Lett 1995; 46:143-52.
18. - T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 2005; 202:309-19.
19. Cowley SC, Elkins KL. Multiple T cell subsets control Francisella tularensis LVS intracellular growth without stimulation through macrophage interferon-γ receptors. J Exp Med 2003; 198:379-89.
20. -(CD4/CD8 double-negative) T lymphocytes in a case of staphylococcal toxic shock syndrome. Acta Haematol 2004; 111:163-7.
21. - T lymphocytes in AIDS patients with disseminated Mycobacterium avium complex infection. J Infect Dis 1996; 174:969-76.
22. - T lymphocytes to a microbial antigen. Nature 1992; 360:593-7.
23. Moody DB, Ulrichs T, Muhlecker W, et al. CD1c-mediated T cell recognition of isoprenoid glycolipids in M. tuberculosis infection. Nature 2000; 404:884-8.
24. Brigl M, Brenne MB. CD1 antigen presentation and T cell function. Ann Rev Immunol 2004; 22:817-90.
25. Bardarov S, Bardarov S, Pavelka MS, et al. Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 2002; 148:3007-17.
26. Delogu G, Li A, Repique C, Collins F, Morris SL. DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induced sustained protective immunity in a mouse model of pulmonary tuberculosis. Infect Immun 2002; 70:292-302.
27. Lutz MB, Kukutsch N, Ogilvie AJ., Rößner S, Koch F, Romani N, Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Meth 1999; 223:77-92.
28. Derrick SC, Yang AL, Morris SL. A polyvalent DNA vaccine expressing an ESAT6-Ag85B fusion protein protects mice against a primary infection with Mycobacterium tuberculosis and boosts BCG-induced protective immunity. Vaccine 2004; 23:780-8.
29. Derrick SC, Repique C, Snoy P, Yang AL, Morris SL. Immunization with a DNA vaccine cocktail protects mice lacking CD4 cells against an aerogenic infection with Mycobacterium tuberculosis. Infect Immun 2004; 72:1685-92.
30. Tyznik AJ, Sun JC, Bevan MJ. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 2004; 199:559-65.
31. Goter-Robinson C, Derrick SC, Yang A, Jeon BY, Morris SL. Protection against an aerogenic Mycobacterium tuberculosis infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses. Vaccine 2006; 24:3522-9.
32. Obaro SK, Pugatch D, Luzuriaga K. Immunogenicity and efficacy of childhood vaccines in HIV-1 infected children. Lancet Infect Dis 2004; 4:510-18.
33. Cooper CL, Davis HL, Angel JB, Morris ML, Eifer SM, Seguin I, Kreig AM, Cameron DW. CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults. AIDS 2005; 19:1473-9.
34. Madhi SA, Kuwanda L, Cutland C, Holm A, Kayhty H, Klugman KP. Quantitative and qualitative antibody response to pneumococcal conjugate vaccine among African human immunodeficiency virus-infected and uninfected children. Pediatr Infect Dis 2005; 24:410-16.
35. Yamanaka H, Teruya K, Tanaka M, Kikuchi Y, Takahashi T, Kimura S, Oka S. and the HIV/Influenza Vaccine Study Team. Efficacy and immunologic responses to influenza vaccine in HIV-infected patients. J Acquir Immune Defic Syndr 2005; 39:167-73.
36. Blank C, Brown I, Marks R, Nishimura H, Honjo T, Gajewski TF. Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative T cells. Immunology 2003; 179:4574-81.
37. Matsuzawa A, Shimizu M, Takeda Y, Nagase H, Sayama K, Kimura M. Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells. Immunology 2002; 106:470-5.
38. Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 1993; 261:1448-51.
39. Wang J, Santosuosso M, Ngai P, Zganiacz A, Xing Z. Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells. J Immunol 2004; 173:4590-7.
40. - T cells with regulatory functions dominates the mouse female genital tract. J Immunol 2003; 170:1659-66.
41. Godfrey DI, MacDonald HR, Dronenberg M, Smyth MJ, Kaer LV. NKT cells: what's in a name? Nat Rev Immunol 2004; 4:231-7.
42. - T cells is increased in HIV disease. AIDS Res Hum Retroviruses 2001; 17:977-80.
43. - T lymphocytes in patients with AIDS and disseminated Mycobacterium avium-intracellulare complex infection: a prospective study. Microbes Infect 1999; 1:771-6.
44. Moody DB, Porcelli SA. Intracellular pathways of CD1 antigen presentation. Nat Rev Immunol 2003; 3:11-22.
45. Sun JC, Bevan MJ. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 2003; 300:339-42.
46. Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating CD8 T cell memory. Science 2003; 300:337-9.
47. + T cells but confers minimal survival advantage on CD4-deficient mice. Proc Natl Acad Sci 2000; 97:2725-30.
48. Wang Q, Malherve L, Zhang D, Zingler K, Glaichenhaus N, Killeen N. CD4 promotes breadth in the TCR repertoire. J Immunol 2001; 167:4311-20.