A single acidic residue can guide binding site selection but does not govern QaCR cationic-drug affinity

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Peters, Kate M ^a   Brooks, Benjamin E ^b   Schumacher, Maria A ^b,d   Skurray, Ronald A ^a   Brennan, Richard G ^b,d   Brown, Melissa H ^a,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c FLINDERS UNIVERSITY   (Australia)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTAMIC ACID; GLUTAMINE; QACR PROTEIN; RHODAMINE 6G; AMINO ACID; BACTERIAL PROTEIN; CATION; DRUG; ETHIDIUM; FUCHSINE; LIGAND; MALACHITE GREEN; QACR PROTEIN, STAPHYLOCOCCUS AUREUS; REPRESSOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; CHEMISTRY; GENETICS; METABOLISM; MISSENSE MUTATION; PROTEIN BINDING;

AMINO ACIDS, ACIDIC; BACTERIAL PROTEINS; BINDING SITES; CATIONS; ETHIDIUM; LIGANDS; MUTATION, MISSENSE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; REPRESSOR PROTEINS; ROSANILINE DYES;

EID: 79251569588     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015974     Document Type: Article

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