Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription

Biochemistry

Volumn 48, Issue 41, 2009, Pages 9794-9800

  Peters, Kate M ^a   Sharbeen, George ^a   Theis, Torsten ^a   Skurray, Ronald A ^a   Brown, Melissa H ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; BINDING POCKETS; BIOCHEMICAL CHARACTERIZATION; DE-REPRESSION; ETHIDIUM; HIGH AFFINITY; LIGAND BINDING; LIPOPHILIC COMPOUNDS; MULTIDRUG EFFLUX; POLAR RESIDUES; RHODAMINE 6G; S. AUREUS; STAPHYLOCOCCUS AUREUS; STRUCTURAL CHANGE; TRANSCRIPTIONALLY ACTIVE;

BINDING ENERGY; BIOCHEMISTRY; CONFORMATIONS; DNA; GENES; NUCLEIC ACIDS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

LIGANDS;

BETA LACTAMASE; DNA; DRUG RESIDUE; ETHIDIUM; LIGAND; QACR PROTEIN; RHODAMINE 6G; TRANSCRIPTION FACTOR;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; BIOCHEMISTRY; CONFORMATION; DISSOCIATION; DNA BINDING; DRUG BINDING; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PURIFICATION; REGULATOR GENE; STAPHYLOCOCCUS AUREUS;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BINDING SITES; DRUG RESISTANCE, MICROBIAL; ETHIDIUM; HOMEOSTASIS; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; REPRESSOR PROTEINS; RHODAMINES; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION, GENETIC;

STAPHYLOCOCCUS AUREUS;

EID: 70350072949     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901102h     Document Type: Article

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