-
2
-
-
34547145226
-
Amyloid beta as a regulator of lipid homeostasis
-
Grimm MO, Grimm HS, Hartmann T. Amyloid beta as a regulator of lipid homeostasis. Trends Mol Med 2007;13: 337-344.
-
(2007)
Trends Mol Med
, vol.13
, pp. 337-344
-
-
Grimm, M.O.1
Grimm, H.S.2
Hartmann, T.3
-
4
-
-
6044221306
-
GM1 ganglioside regulates the proteolysis of amyloid precursor protein
-
Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D. GM1 ganglioside regulates the proteolysis of amyloid precursor protein. Mol Psychiatry 2004;9:946-952.
-
(2004)
Mol Psychiatry
, vol.9
, pp. 946-952
-
-
Zha, Q.1
Ruan, Y.2
Hartmann, T.3
Beyreuther, K.4
Zhang, D.5
-
5
-
-
0001504829
-
Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
-
Fassbender K, Simons M, Bergmann C, et al. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:5856-5861.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5856-5861
-
-
Fassbender, K.1
Simons, M.2
Bergmann, C.3
-
6
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998;95:6460-6464.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dotti, C.G.5
Simons, K.6
-
7
-
-
0036180950
-
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
-
Wahrle S, Das P, Nyborg AC, et al. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 2002;9:11-23.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
-
8
-
-
0141886877
-
Niemann-Pick disease type C
-
Vanier MT, Millat G. Niemann-Pick disease type C. Clin Genet 2003;64:269-281.
-
(2003)
Clin Genet
, vol.64
, pp. 269-281
-
-
Vanier, M.T.1
Millat, G.2
-
9
-
-
33846412228
-
The natural history of Niemann-Pick disease type C in the UK
-
Imrie J, Dasgupta S, Besley GT, et al. The natural history of Niemann-Pick disease type C in the UK. J Inherit Metab Dis 2007;30:51-59.
-
(2007)
J Inherit Metab Dis
, vol.30
, pp. 51-59
-
-
Imrie, J.1
Dasgupta, S.2
Besley, G.T.3
-
10
-
-
33845910402
-
The adult form of Niemann-Pick disease type C
-
Sevin M, Lesca G, Baumann N, et al. The adult form of Niemann-Pick disease type C. Brain 2007;130:120-133.
-
(2007)
Brain
, vol.130
, pp. 120-133
-
-
Sevin, M.1
Lesca, G.2
Baumann, N.3
-
11
-
-
0035142802
-
Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations
-
Zervas M, Dobrenis K, Walkley SU. Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations. J Neuropathol Exp Neurol 2001;60: 49-64.
-
(2001)
J Neuropathol Exp Neurol
, vol.60
, pp. 49-64
-
-
Zervas, M.1
Dobrenis, K.2
Walkley, S.U.3
-
12
-
-
0035928841
-
Critical role for glycosphingolipids in Niemann-Pick disease type C
-
Zervas M, Somers KL, Thrall MA, Walkley SU. Critical role for glycosphingolipids in Niemann-Pick disease type C. Curr Biol 2001;11:1283-1287.
-
(2001)
Curr Biol
, vol.11
, pp. 1283-1287
-
-
Zervas, M.1
Somers, K.L.2
Thrall, M.A.3
Walkley, S.U.4
-
13
-
-
36849065071
-
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies
-
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007;370:1453-1457.
-
(2007)
Lancet
, vol.370
, pp. 1453-1457
-
-
Von Elm, E.1
Altman, D.G.2
Egger, M.3
Pocock, S.J.4
Gotzsche, P.C.5
Vandenbroucke, J.P.6
-
14
-
-
77049091787
-
Converging molecular pathways in human neural development and degeneration
-
Mattsson N, Savman K, Osterlundh G, Blennow K, Zetterberg H. Converging molecular pathways in human neural development and degeneration. Neurosci Res 2010; 66:330-332.
-
(2010)
Neurosci Res
, vol.66
, pp. 330-332
-
-
Mattsson, N.1
Savman, K.2
Osterlundh, G.3
Blennow, K.4
Zetterberg, H.5
-
15
-
-
73949159934
-
Linear clinical progression, independent of age of onset, in Niemann-Pick disease, type C
-
Yanjanin NM, Velez JI, Gropman A, et al. Linear clinical progression, independent of age of onset, in Niemann-Pick disease, type C. Am J Med Genet B Neuropsychiatr Genet 2010;153B:132-140.
-
(2010)
Am J Med Genet B Neuropsychiatr Genet
, vol.153 B
, pp. 132-140
-
-
Yanjanin, N.M.1
Velez, J.I.2
Gropman, A.3
-
16
-
-
34547753513
-
Miglustat for treatment of Niemann-Pick C disease: A randomised controlled study
-
Patterson MC, Vecchio D, Prady H, Abel L, Wraith JE. Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study. Lancet Neurol 2007;6:765-772.
-
(2007)
Lancet Neurol
, vol.6
, pp. 765-772
-
-
Patterson, M.C.1
Vecchio, D.2
Prady, H.3
Abel, L.4
Wraith, J.E.5
-
17
-
-
12944312683
-
Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
-
Olsson A, Vanderstichele H, Andreasen N, et al. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin Chem 2005;51:336-345.
-
(2005)
Clin Chem
, vol.51
, pp. 336-345
-
-
Olsson, A.1
Vanderstichele, H.2
Andreasen, N.3
-
19
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A be-ta40/42 amyloid peptides
-
Hartmann T, Bieger SC, Bruhl B, et al. Distinct sites of intracellular production for Alzheimer's disease A be-ta40/42 amyloid peptides. Nat Med 1997;3:1016-1020.
-
(1997)
Nat Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
-
20
-
-
53049089639
-
Direct and potent regulation of gamma-secretase by its lipid microenvironment
-
Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem 2008;283:22529-22540.
-
(2008)
J Biol Chem
, vol.283
, pp. 22529-22540
-
-
Osenkowski, P.1
Ye, W.2
Wang, R.3
Wolfe, M.S.4
Selkoe, D.J.5
-
21
-
-
77951727293
-
Lipids on trial: The search for the offending metabolite in Niemann-Pick type C disease
-
Lloyd-Evans E, Platt FM. Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease. Traffic 2010;11:419-428.
-
(2010)
Traffic
, vol.11
, pp. 419-428
-
-
Lloyd-Evans, E.1
Platt, F.M.2
-
22
-
-
0041700117
-
Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent
-
Gondre-Lewis MC, McGlynn R, Walkley SU. Cholesterol accumulation in NPC1-deficient neurons is ganglioside dependent. Curr Biol 2003;13:1324-1329.
-
(2003)
Curr Biol
, vol.13
, pp. 1324-1329
-
-
Gondre-Lewis, M.C.1
McGlynn, R.2
Walkley, S.U.3
-
23
-
-
1542719049
-
The Niemann-Pick disease genes; Regulators of cellular cholesterol homeostasis
-
Ory DS. The Niemann-Pick disease genes; regulators of cellular cholesterol homeostasis. Trends Cardiovasc Med 2004;14:66-72.
-
(2004)
Trends Cardiovasc Med
, vol.14
, pp. 66-72
-
-
Ory, D.S.1
-
24
-
-
4744365602
-
Consequences of NPC1 and NPC2 loss of function in mammalian neurons
-
Walkley SU, Suzuki K. Consequences of NPC1 and NPC2 loss of function in mammalian neurons. Biochim Biophys Acta 2004;1685:48-62.
-
(2004)
Biochim Biophys Acta
, vol.1685
, pp. 48-62
-
-
Walkley, S.U.1
Suzuki, K.2
-
25
-
-
76449085569
-
Gamma-secretases: From cell biology to therapeutic strategies
-
Bergmans BA, De Strooper B. Gamma-secretases: from cell biology to therapeutic strategies. Lancet Neurol 2010; 9:215-226.
-
(2010)
Lancet Neurol
, vol.9
, pp. 215-226
-
-
Bergmans, B.A.1
De Strooper, B.2
-
26
-
-
77952519104
-
Synaptic and endo-somal localization of active gamma-secretase in rat brain
-
Frykman S, Hur JY, Franberg J, et al. Synaptic and endo-somal localization of active gamma-secretase in rat brain. PLoS One 2010;5:e8948.
-
(2010)
PLoS One
, vol.5
-
-
Frykman, S.1
Hur, J.Y.2
Franberg, J.3
-
27
-
-
67649275699
-
Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells
-
Karten B, Peake KB, Vance JE. Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. Biochim Biophys Acta 2009;1791:659-670.
-
(2009)
Biochim Biophys Acta
, vol.1791
, pp. 659-670
-
-
Karten, B.1
Peake, K.B.2
Vance, J.E.3
-
28
-
-
70350455062
-
The beta-secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential
-
Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci 2009;29:12787-12794.
-
(2009)
J Neurosci
, vol.29
, pp. 12787-12794
-
-
Vassar, R.1
Kovacs, D.M.2
Yan, R.3
Wong, P.C.4
-
29
-
-
0035815635
-
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding: The pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
-
Benjannet S, Elagoz A, Wickham L, et al. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding: the pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J Biol Chem 2001; 276:10879-10887.
-
(2001)
J Biol Chem
, vol.276
, pp. 10879-10887
-
-
Benjannet, S.1
Elagoz, A.2
Wickham, L.3
-
30
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter J, Fluhrer R, Hartung B, et al. Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 2001;276:14634-14641.
-
(2001)
J Biol Chem
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
-
31
-
-
0141482022
-
Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein
-
Cordy JM, Hussain I, Dingwall C, Hooper NM, Turner AJ. Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein. Proc Natl Acad Sci USA 2003;100:11735-11740.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 11735-11740
-
-
Cordy, J.M.1
Hussain, I.2
Dingwall, C.3
Hooper, N.M.4
Turner, A.J.5
-
32
-
-
62149091579
-
Alzheimer disease Abeta production in the absence of S-palmitoylation- dependent targeting of BACE1 to lipid rafts
-
Vetrivel KS, Meckler X, Chen Y, et al. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem 2009;284:3793-3803.
-
(2009)
J Biol Chem
, vol.284
, pp. 3793-3803
-
-
Vetrivel, K.S.1
Meckler, X.2
Chen, Y.3
-
33
-
-
59149083352
-
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhu-man primates
-
Sankaranarayanan S, Holahan MA, Colussi D, et al. First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhu-man primates. J Pharmacol Exp Ther 2009;328:131-140.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 131-140
-
-
Sankaranarayanan, S.1
Holahan, M.A.2
Colussi, D.3
-
34
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
-
Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc Natl Acad Sci USA 2001;98:5815-5820.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5815-5820
-
-
Kojro, E.1
Gimpl, G.2
Lammich, S.3
Marz, W.4
Fahrenholz, F.5
-
35
-
-
0035897938
-
Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
-
Kivipelto M, Helkala EL, Laakso MP, et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ 2001;322:1447-1451.
-
(2001)
BMJ
, vol.322
, pp. 1447-1451
-
-
Kivipelto, M.1
Helkala, E.L.2
Laakso, M.P.3
-
36
-
-
68249134074
-
The role of apolipopro-tein e in Alzheimer's disease
-
Kim J, Basak JM, Holtzman DM. The role of apolipopro-tein E in Alzheimer's disease. Neuron 2009;63:287-303.
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
37
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo LM, Pappolla MA, LaFrancois J, et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neu-robiol Dis 2001;8:890-899.
-
(2001)
Neu-robiol Dis
, vol.8
, pp. 890-899
-
-
Refolo, L.M.1
Pappolla, M.A.2
Lafrancois, J.3
-
38
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 2000;57:1439-1443.
-
(2000)
Arch Neurol
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
39
-
-
0036714243
-
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
-
Simons M, Schwarzler F, Lutjohann D, et al. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol 2002;52:346-350.
-
(2002)
Ann Neurol
, vol.52
, pp. 346-350
-
-
Simons, M.1
Schwarzler, F.2
Lutjohann, D.3
-
40
-
-
20844440894
-
Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results
-
Sparks DL, Sabbagh MN, Connor DJ, et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 2005;62:753-757.
-
(2005)
Arch Neurol
, vol.62
, pp. 753-757
-
-
Sparks, D.L.1
Sabbagh, M.N.2
Connor, D.J.3
|