Attenuated phrenic long-term facilitation in orexin neuron-ablated mice

Respiratory Physiology and Neurobiology

Volumn 168, Issue 3, 2009, Pages 295-302

  Toyama, Shinichi ^a   Sakurai, Takeshi ^b   Tatsumi, Koichiro ^a   Kuwaki, Tomoyuki ^a,c  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Hypocretin; Hypothalamus; Hypoxia

Indexed keywords

OREXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; ATTENUATION; CONTROLLED STUDY; FACILITATION; HYPOXIA; LONG TERM FACILITATION; MALE; MOUSE; NERVE CELL; NERVE CONDUCTION; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; TIDAL VOLUME; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ANOXIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LONG-TERM POTENTIATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROPEPTIDES; PHRENIC NERVE; RESPIRATORY MECHANICS; TIME FACTORS; VAGOTOMY;

EID: 69249212575     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2009.07.025     Document Type: Article

References (49)

1. Bach K.B., and Mitchell G.S. Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir. Physiol. 104 (1996) 251-260
2. Baker T.L., and Mitchell G.S. Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats. J. Physiol. 529 (2000) 215-219
3. Berthoud H.R., Patterson L.M., Sutton G.M., Morrison C., and Zheng H. Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation. Histochem. Cell Biol. 123 (2005) 147-156
4. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
5. Chokroverty S. Sleep apnea in narcolepsy. Sleep 9 (1986) 250-253
6. Deng B.-S., Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice. J. Appl. Physiol. 103 (2007) 1772-1779
7. Dutschmann M., Kron M., Mörschel M., and Gestreau C. Activation of orexin B receptors in the pontine Kölliker-Fuse nucleus modulates pre-inspiratory hypoglossal motor activity in rat. Respir. Physiol. Neurobiol. 159 (2007) 232-235
8. Feldman J.L., Mitchell G.S., and Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Annu. Rev. Neurosci. 26 (2003) 239-266
9. Fregosi R.F., and Mitchell G.S. Long-term facilitation of inspiratory intercostal nerve activity following carotid sinus nerve stimulation in cats. J. Physiol. 477 (1994) 469-479
10. Fung S.J., Yamuy J., Sampogna S., Morales F.R., and Chase M.H. Hypocretin (orexin) input to trigeminal and hypoglossal motoneurons in the cat: a double-labeling immunohistochemical study. Brain Res. 903 (2001) 257-262
11. Gestreau C., Bévengut M., and Dutschmann M. The dual role of the orexin/hypocretin system in modulating wakefulness and respiratory drive. Curr. Opin. Pulm. Med. 14 (2008) 512-518
12. Han F., Subramanian S., Price E.R., Nadeau J., and Strohl K.P. Periodic breathing in the mouse. J. Appl. Physiol. 92 (2002) 1133-1140
13. Hara J., Beuckmann C.T., Nambu T., Willie J.T., Chemelli R.M., Sinton C.M., Sugiyama F., Yagami K., Goto K., Yanagisawa M., and Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30 (2001) 345-354
14. Hayashi F., Coles S.K., Bach K.B., Mitchell G.S., and McCrimmon D.R. Time-dependent phrenic nerve responses to carotid afferent activation: intact vs. decerebellate rats. Am. J. Physiol. 265 (1993) R811-819
15. Kayaba Y., Nakamura A., Kasuya Y., Ohuchi T., Yanagisawa M., Komuro I., Fukuda Y., and Kuwaki T. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003) R581-R593
16. Kline D.D., Overholt J.L., and Prabhakar N.R. Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. J. Physiol. 539 (2002) 309-315
17. Kuwaki T. Orexinergic modulation of breathing across vigilance states. Respir. Physiol. Neurobiol. 164 (2008) 204-212
18. Kuwaki T., Cao W.H., Kurihara Y., Kurihara H., Ling G.Y., Onodera M., Ju K.H., Yazaki Y., and Kumada M. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1. Am. J. Physiol. 270 (1996) R1279-1286
19. Kuwaki T., Zhang W., Nakamura A., and Deng B. Emotional and state-dependent modification of cardiorespiratory function: role of orexinergic neurons. Auton. Neurosci. 142 (2008) 11-16
20. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
21. Ma S., Mifflin S.W., Cunningham J.T., and Morilak D.A. Chronic intermittent hypoxia sensitizes acute hypothalamic-pituitary-adrenal stress reactivity and Fos induction in the rat locus coeruleus in response to subsequent immobilization stress. Neuroscience 154 (2008) 1639-1647
22. Mahamed S., and Mitchell G.S. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?. Exp. Physiol. 92 (2007) 27-37
23. Mateika J.H., and Narwani G. Intermittent hypoxia and respiratory plasticity in humans and other animals: does exposure to intermittent hypoxia promote or mitigate sleep apnoea?. Exp. Physiol. 94 (2009) 279-296
24. McGuire M., Zhang Y., White D.P., and Ling L. Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats. J. Appl. Physiol. 93 (2002) 2155-2161
25. Millhorn D.E. Stimulation of raphe (obscurus) nucleus causes long-term potentiation of phrenic nerve activity in cat. J. Physiol. 381 (1986) 169-179
26. Millhorn D.E., Eldridge F.L., and Waldrop T.G. Prolonged stimulation of respiration by a new central neural mechanism. Respir. Physiol. 41 (1980) 87-103
27. Millhorn D.E., Eldridge F.L., and Waldrop T.G. Prolonged stimulation of respiration by endogenous central serotonin. Respir. Physiol. 42 (1980) 171-188
28. Mitchell G.S., Baker T.L., Nanda S.A., Fuller D.D., Zabka A.G., Hodgeman B.A., Bavis R.W., Mack K.J., and Olson Jr. E.B. Intermittent hypoxia and respiratory plasticity. J. Appl. Physiol. 90 (2001) 2466-2475
29. Mitchell G.S., Powell F.L., Hopkins S.R., and Milsom W.K. Time domains of the hypoxic ventilatory response in awake ducks: episodic and continuous hypoxia. Respir. Physiol. 124 (2001) 117-128
30. Morris K.F., Baekey D.M., Shannon R., and Lindsey B.G. Respiratory neural activity during long-term facilitation. Respir. Physiol. 121 (2000) 119-133
31. Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., and Kuwaki T. Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. J. Appl. Physiol. 102 (2007) 241-248
32. Olson Jr. E.B., Bohne C.J., Dwinell M.R., Podolsky A., Vidruk E.H., Fuller D.D., Powell F.L., and Mitchel G.S. Ventilatory long-term facilitation in unanesthetized rats. J. Appl. Physiol. 91 (2001) 709-716
33. Peng Y.J., Overholt J.L., Kline D., Kumar G.K., and Prabhakar N.R. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 10073-10078
34. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., and Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18 (1998) 9996-10015
35. Rosin D.L., Chang D.A., and Guyenet P.G. Afferent and efferent connections of the rat retrotrapezoid nucleus. J. Comp. Neurol. 499 (2006) 64-89
36. Sakurai T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat. Rev. Neurosci. 8 (2007) 171-181
37. Semenza G.L. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp. Physiol. 91 (2006) 803-806
38. Stettner G.M., Zanella S., Huppke P., Gärtner J., Hilaire G., and Dutschmann M. Spontaneous central apneas occur in the C57BL/6J mouse strain. Respir. Physiol. Neurobiol. 160 (2008) 21-27
39. Tankersley C.G., Fitzgerald R.S., and Kleeberger S.R. Differential control of ventilation among inbred strains of mice. Am. J. Physiol. 267 (1994) R1371-1377
40. Terada J., Nakamura A., Zhang W., Yanagisawa M., Kuriyama T., Fukuda Y., and Kuwaki T. Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin. J. Appl. Physiol. 104 (2008) 499-507
41. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., and Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 (2000) 469-474
42. Turner D.L., and Mitchell G.S. Long-term facilitation of ventilation following repeated hypoxic episodes in awake goats. J. Physiol. 499 Pt 2 (1997) 543-550
43. Williams R., and Burdakov D. Hypothalamic orexins/hypocretins as regulators of breathing. Expert. Rev. Mol. Med. 10 (2008) e28
44. Willie J.T., Chemelli R.M., Sinton C.M., and Yanagisawa M. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 24 (2001) 429-458
45. Young J.K., Wu M., Manaye K.F., Kc P., Allard J.S., Mack S.O., and Haxhiu M.A. Orexin stimulates breathing via medullary and spinal pathways. J. Appl. Physiol. 98 (2005) 1387-1395
46. Zhang W., Fukuda Y., and Kuwaki T. Respiratory and cardiovascular actions of orexin-A in mice. Neurosci. Lett. 385 (2005) 131-136
47. Zhang W., Sakurai T., Fukuda Y., and Kuwaki T. Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (2006) R1654-R1663
48. Zhang W., Shimoyama M., Fukuda Y., and Kuwaki T. Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice. Auton. Neurosci. 126-127 (2006) 139-145
49. Zhang W., Zhang N., Sakurai T., and Kuwaki T. Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. Brain Res. 1262 (2009) 25-37