Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones

Journal of Physiology

Volumn 549, Issue 3, 2003, Pages 809-821

  van den Top, Marco ^e   Nolan, Matthew F ^a   Lee, Kevin ^e   Richardson, Peter J ^b   Buijs, Ruud M ^c   Davies, Ceri H ^d   Spanswick, David ^e  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^d GLAXOSMITHKLINE   (United Kingdom)

^e UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; NEUROPEPTIDE RECEPTOR; OREXIN A; OREXIN B; PERTUSSIS TOXIN; POTASSIUM ION; RECEPTOR BLOCKING AGENT; 1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; CALCIUM; OREXIN; OREXIN 1 RECEPTOR;

ADRENERGIC TRANSMISSION; ANIMAL TISSUE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CALCIUM CELL LEVEL; CARDIOVASCULAR RESPONSE; CELL SYNCHRONIZATION; CONTROLLED STUDY; DENDRITE; ENERGY METABOLISM; EXCITATION CONTRACTION COUPLING; EXPERIMENTAL DENERVATION; GAP JUNCTION; HYPOTHALAMUS; IN VIVO STUDY; LIVER; MALE; MEMBRANE CONDUCTANCE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE PROJECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATION; PEPTIDE SYNTHESIS; POTASSIUM CONDUCTANCE; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDORABIES HERPETOVIRUS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SPINAL CORD; SPINAL NERVE; SYMPATHETIC NERVE CELL; TISSUE SLICE; ADULT; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC DENERVATION; EXCITABILITY; EXCITATION; HOMEOSTASIS; LATERAL HYPOTHALAMUS; NERVE CELL; NEUROMODULATION; PARASYMPATHETIC TONE; PERCEPTIVE THRESHOLD; SYMPATHETIC NERVE;

ADRENERGIC FIBERS; ANIMALS; AUTONOMIC FIBERS, PREGANGLIONIC; BENZOXAZOLES; CARRIER PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTROPHYSIOLOGY; GTP-BINDING PROTEINS; HYPOTHALAMIC AREA, LATERAL; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MICROSCOPY, VIDEO; NEURAL PATHWAYS; NEURONS; NEUROPEPTIDES; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UREA;

EID: 0038380613     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.033290     Document Type: Review

References (44)

1. Artunes VR, Brailoiu GC, Kwok EH, Scruggs P& Dun NJ (2001). Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol 281, R1801-1807.
2. Bernardis LL& Bellinger LL (1993). The lateral hypothalamic area revisited - neuroanatomy, body-weight regulation, neuroendocrinology and metabolism. Neurosci Biobehav Rev 17, 141-193.
3. Bleasdale JE, Thakur NR, Gremban RS, Bundy GE, Fitzpatrick FA, Smith RJ & Bunting S (1990). Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharm Exp Ther 256, 756-768.
4. Brown RE, Sergeeva O, Eriksson KS & Haas H (2001). Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology 40, 457-459.
5. Buijs RM, Chun SJ, Niijima A, Romijn HJ & Nagai K (2001). Parasympathetic and sympathetic control of the pancreas, a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol 431, 405-423.
6. Chen CT, Hwang LL, Chang JK & Dun NJ (2000). Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am J Physiol 278, R692-697.
7. Coote JH (1988). The organisation of cardiovascular neurons in the spinal cord. Rev Physiol Biochem Pharmacol 110, 147-285.
8. Date Y, Mondal MS, Matsukura S & Nakazato M (2000). Distribution of orexin-A and orexin-B (hypocretins) in the rat spinal cord. Neurosci Lett 288, 87-90.
9. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM & Sutcliffe JG (1998). The hypocretins, hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95, 322-327.
10. Dixon AK, Richardson PJ, Lee K, Carter N & Freeman TC (1998). Expression profiling of single cells using 3 prime end amplification (TPEA) PCR. Nucleic Acids Res 26, 4426-4431.
11. Gibson IC & Logan SD (1995). Effects of muscarinic receptor stimulation of sympathetic preganglionic neurones of neonatal rat spinal cord in vitro. Neuropharmacology 34, 309-318.
12. Greco MA & Shiromani PJ (2001). Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Brain Res Mol Brain Res 88, 176-182.
13. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DNC, Smith MI, Piper DC, Hunter AJ, Porter RA & Upton N (1999). Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A 96, 10911-10916.
14. Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS & van den Pol AN (1999) Hypocretin (Orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 415, 145-159.
15. Ivanov A & Aston-Jones G (2000). Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport 11, 1755-1758.
16. LeDoux JE (1995). Emotion - clues from the brain. Annu Rev Psychol 46, 209-235.
17. Lee K, Dixon AK, Richardson PJ & Pinnock RD ( 1999). Glucose-receptive neurones in the rat ventromedial hypothalamus express K-ATP channels composed of Kir6.1 and SUR1 subunits. J Physiol 515, 439-452.
18. Lin S & Huang XF (1999). Altered hypothalamic c-Fos-like immunoreactivity in diet-induced obese mice. Brain Res Bull 49, 215-219.
19. Logan SD, Pickering AE, Gibson IC, Nolan MF & Spanswick D (1996). Electrotonic coupling between rat sympathetic preganglionic neurones in vitro. J Physiol 495, 491-502.
20. Matsumura K, Tsuchihashi T & Abe I (2001). Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension 37, 1382-1387.
21. Nolan MF & Logan SD (1998). Metabotropic glutamate receptor-mediated excitation and inhibition of sympathetic preganglionic neurones. Neuropharmacology 37, 13-24.
22. Nolan MF, Logan SD & Spanswick D ( 1999). Electrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitro. J Physiol 519, 753-764.
23. Pickering AE, Spanswick D & Logan SD (1991). Whole-cell recordings from sympathetic preganglionic neurons in rat spinal cord slices. Neurosci Lett 130, 237-242.
24. Pickering AE, Spanswick D & Logan SD (1994). 5-HT-induced depolarisation and membrane potential oscillations in rat sympathetic preganglionic neurons in vitro. J Physiol 480, 109-121.
25. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JrS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS,Terrett JA, Elshourbagy NA, Bergsma DJ & Yanagisawa M (1998). Urexins and orexin receptors, a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585.
26. Samson WK, Gosnell B, Chang JK, Resch ZT & Murphy TC (1999). Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 831, 248-253.
27. Shirasaka T, Nakazato M, Matsukura S, Takasaki M & Kannan H (1999). Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 277, R1780-1785.
28. Smart D, Jerman JC, Brough SJ, Neville WA, Jewitt F & Porter RA (2000). The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors. Br J Pharmacol 129, 1289-1291.
29. Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA & Jerman JC (2001). SB-334867-A, the first selective orexin-1 receptor antagonist. Br J Pharmacol 132, 1179-1182.
30. Smith OA, Devito JL &Astley CA (1990). Neurons controlling cardiovascular responses to emotion are located in lateral hypothalamus-perifornical region. Am J Physiol 259, R943-954.
31. Soffin EM, Evans ML, Gill CH, Harries MH, Benham CD & Davies CH (2002). SB-334867-A antagonises orexin mediated excitation in the locus coeruleus. Neuropharmacology 42, 127-133.
32. Spanswick D & Logan SD (1990). Spontaneous rhythmic activity in the intermediolateral cell nucleus of the neonatal rat thoracolumbar spinal cord in vitro. Neurosci 39, 395-403.
33. Spanswick D, Pickering AE, Gibson IC & Logan SD (1995). Excitation of sympathetic preganglionic neurones via metabotropic excitatory amino acid receptors. Neurosci 68, 1247-1261.
34. Strack AM & Loewy AD (1990). Pseuorabies virus, a highly specific transneuronal cell body marker in the sympathetic nervous system. J Neurosci 10, 2139-2147.
35. Strack AM, Sawyer WB, Hughes JH, Platt KB & Loewy AD (1989). A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res 491, 156-162.
36. Stuart GJ, Dodt HU & Sakmann B (1993). Patch-clamp recordings from the soma and dendrites of neurons in brain-slices using infrared video microscopy. Pflugers Arch 423, 511-518.
37. Sunter D, Morgan I, Edwards MB, Dakin, CL, Murphy KG, Gardiner J, Taheri S, Raves E & Bloom SR (2001). Orexins, effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem. Brain Research 907, 27-34.
38. Surmeier DJ, Song W-J & Yan Z (1996). Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci 16, 6579-6591.
39. Travagli RA, Dunwiddie TV & Williams JT (1995). Opioid inhibition in the locus coeruleus. J Neurophysiol 74, 519-528.
40. van den Pol AN (1999). Hypothalamic hypocretin (orexin), robust innervation of the spinal cord. J Neurosci 19, 3171-3182.
41. van den Pol AN, Gao XB, Obrietan K, Kilduff TS & Belousov AB (1998). Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, Hypocretin/Orexin. J Neurosci 18, 7962-7971.
42. van den Pol AN, Ghosh PK, Liu R, Li Y, Aghajanian GK & Gao X-B (2002) Hypocretin (Orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J Physiol 541, 169-185.
43. van den Top M, Lee K, Richardson PJ, Spanswick D & Nolan MF (2000). Orexin depolarizes rat sympathetic preganglionic neurones in vitro. J Physiol 528.P, 107-108P.
44. van den Top M, Buijs RM, Ruijter JM, Delagrange P, Spanswick D & Hermes MLHJ (2001). Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm. Neurosci 107, 99-108.