Dietary ascorbate intake affects steady state tissue concentrations in vitamin C-deficient mice: Tissue deficiency after suboptimal intake and superior bioavailability from a food source (kiwifruit)

American Journal of Clinical Nutrition

Volumn 93, Issue 2, 2011, Pages 292-301

  Vissers, Margreet C M ^a   Bozonet, Stephanie M ^a   Pearson, John F ^a   Braithwaite, Lewis J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; DRINKING WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCORBIC ACID DEFICIENCY; BIOAVAILABILITY; BRAIN; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; HEART; KIDNEY; KIWIFRUIT; LEUKOCYTE; LIVER; MALE; MOUSE; NONHUMAN; STEADY STATE; TISSUE LEVEL; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; WILD TYPE;

ACTINIDIA; ANIMALS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; BIOLOGICAL AVAILABILITY; DIET; DISEASE MODELS, ANIMAL; DRINKING; FRUIT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLANT EXTRACTS; TISSUE DISTRIBUTION; WATER;

ACTINIDIA DELICIOSA; ANIMALIA; GULO; MUS;

EID: 79251493788     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.004853     Document Type: Article

References (60)

1. Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med 1986;314:892-902. (Pubitemid 16126118)
2. Banhegyi G, Braun L, Csala M, Puskas F, Mandl J. Ascorbate metabolism and its regulation in animals. Free Radic Biol Med 1997;23:793-803.
3. Chatterjee IB, Majumder AK, Nandi BK, Subramanian N. Synthesis and some major functions of vitamin C in animals. Ann N YAcad Sci 1975;258:24-47.
4. Tsao CS. An overview of ascorbic acid chemistry and biochemistry. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. 1st ed. New York, NY: Marcel Dekker, 1997:25-58.
5. Sauberlich HE. A history of scurvy and vitamin C. In: Packer L, Fuchs J, eds. Vitamin C in health and disease. 1st ed. New York, NY: Marcel Dekker, 1997:1-24.
6. Ozer A, Bruick RK. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat Chem Biol 2007;3:144-53.
7. Flashman E, Davies SL, Yeoh KK, Schofield CJ. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J 2010;427:135-42.
8. Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 2009;157:1097-110.
9. Gronke RS, Welsch DJ, VanDusen WJ, et al. Partial purification and characterization of bovine liver aspartyl beta-hydroxylase. J Biol Chem 1990;265:8558-65.
10. Dinchuk JE, Focht RJ, Kelley JA, et al. Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem 2002;277:12970-7.
11. Kaczmarek M, Cachau RE, Topol IA, Kasprzak KS, Ghio A, Salnikow K. Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci 2009;107:394-403.
12. Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyharju J. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 2004;279:9899-904.
13. Myllyla R, Kuutti-Savolainen ER, Kivirikko KI. The role of ascorbate in the prolyl hydroxylase reaction. Biochem Biophys Res Commun 1978;83:441-8.
14. de Jong L, Albracht SP, Kemp A. Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron. The role of ascorbate in peptidyl proline hydroxylation. Biochim Biophys Acta 1982;704:326-32.
15. Peet D, Linke S. Regulation of HIF: asparaginyl hydroxylation. Novartis Found Symp 2006;272:37-49; discussion 49-53, 131-40.
16. Semenza GL. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp Physiol 2006;91:803-6.
17. Jones DT, Trowbridge IS, Harris AL. Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. Cancer Res 2006;66:2749-56.
18. Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res 2003;63:1764-8.
19. Vissers MC, Gunningham SP, Morrison MJ, Dachs GU, Currie MJ. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radic Biol Med 2007;42:765-72.
20. Page EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell 2008;19:86-94. (Pubitemid 351186135)
21. Harrison FE, May JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med 2009;46:719-30.
22. May JM, Qu ZC. Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis. Arch Biochem Biophys 2005;434:178-86.
23. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 2008;34:347-55.
24. Levine M, Cantilena CC, Dhariwal KR. In situ kinetics and ascorbic acid requirements. World Rev Nutr Diet 1993;72:114-27.
25. Levine M, Rumsey S, Wang Y. Principles involved in formulating recommendations for vitamin C intake: a paradigm for water-soluble vitamins. Methods Enzymol 1997;279:43-54.
26. Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996;93:3704-9.
27. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69:1086-107.
28. Panel on Dietary Antioxidants and Related Compounds, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium and carotenoids. Washington, DC: National Academy Press, 2000:79-185.
29. Levine M, Wang Y, Padayatty SJ, Morrow J. A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 2001;98:9842-6.
30. Maeda N, Hagihara H, Nakata Y, Hiller S, Wilder J, Reddick R. Aortic wall damage in mice unable to synthesize ascorbic acid. Proc Natl Acad Sci USA 2000;97:841-6. (Pubitemid 30070397)
31. Parsons KK, Maeda N, Yamauchi M, Banes AJ, Koller BH. Ascorbic acid-independent synthesis of collagen in mice. Am J Physiol Endocrinol Metab 2006;290:E1131-9.
32. Gaut JP, Belaaouaj A, Byun J, et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic Biol Med 2006;40:1494-501.
33. Nishiyama I, Yamashita Y, Yamanaka M, Shimohashi A, Fukuda T, Oota T. Varietal difference in vitamin C content in the fruit of kiwifruit and other actinidia species. J Agric Food Chem 2004;52:5472-5.
34. Vissers MC, Wilkie RP. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha. J Leukoc Biol 2007;81:1236-44.
35. R Foundation for Statistical Computing. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2008.
36. Ritz C, Streibig JC. Bioassay analysis using R. J Stat Software, 2005;12:1-22.
37. Tanaka K, Hashimoto T, Tokumaru S, Iguchi H, Kojo S. Interactions between vitamin C and vitamin E are observed in tissues of inherently scorbutic rats. J Nutr 1997;127:2060-4. (Pubitemid 27424447)
38. Tokumaru S, Takeshita S, Nakata R, Tsukamoto I, Kojo S. Change in the level of vitamin C and lipid peroxidation in tissues of the inherently sorbutic rat during ascorbate deficiency. J Agric Food Chem 1996;44:2748-53.
39. Wenzl MV, Wolkart G, Stessel H, Beretta M, Schmidt K, Mayer B. Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin. Br J Pharmacol 2009;156:1248-55.
40. Majumder AK, Nandi BK, Subramanian N, Chatterjee IB. Nutrient interrelationship of ascorbic acid and iron in rats and guinea pigs fed cereal diets. J Nutr 1975;105:240-4.
41. Levine M, Dhariwal KR, Welch RW, Wang Y, Park JB. Determination of optimal vitamin C requirements in humans. Am J Clin Nutr 1995;62:1347S-56S.
42. Loria CM, Klag MJ, Caulfield LE, Whelton PK. Vitamin C status and mortality in US adults. Am J Clin Nutr 2000;72:139-45.
43. Hodges RE, Baker EM, Hood J, Sauberlich HE, March SC. Experimental scurvy in man. Am J Clin Nutr 1969;22:535-48.
44. Padayatty SJ, Katz A, Wang Y, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr 2003;22:18-35.
45. Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res 1996;25:439-54.
46. Mikirova NA, Ichim TE, Riordan NH. Anti-angiogenic effect of high doses of ascorbic acid. J Transl Med 2008;6:50.
47. Corpe CP, Tu H, Eck P, et al. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest 2010;120:1069-83.
48. Riemersma RA, Carruthers KF, Elton RA, Fox KA. Vitamin C and the risk of acute myocardial infarction. Am J Clin Nutr 2000;71:1181-6.
49. Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT. Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study. Am J Clin Nutr 2008;87:64-9.
50. Li W, Maeda N, Beck MA. Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo2/2 mice. J Nutr 2006;136:2611-6.
51. Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ 2001;164:353-5. (Pubitemid 32164958)
52. Padayatty SJ, Levine M. Fruit and vegetables: think variety, go ahead, eat! Am J Clin Nutr 2008;87:5-7.
53. Cotereau H, Gabe M. Influence of vitamin P (vitamin C2) upon the amount of ascorbic acid in the organs of the guinea pig. Nature 1948;161:557.
54. Celik A, Ercisli S, Turgut N. Some physical, pomological and nutritional properties of kiwifruit cv. Hayward. Int J Food Sci Nutr 2007;58:411-8.
55. Nishiyama I. Fruits of the actinidia genus. Adv Food Nutr Res 2007;52:293-324.
56. Vinson JA, Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601-4.
57. Baird IM, Hughes RE, Wilson HK, Davies JE, Howard AN. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Am J Clin Nutr 1979;32:1686-90.
58. Song J, Kwon O, Chen S, et al. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and Glucose. J Biol Chem 2002;277:15252-60.
59. Chacon E, Ulrich R, Acosta D. A digitized-fluorescence-imaging study of mitochondrial Ca2+ increase by doxorubicin in cardiac myocytes. Biochem J 1992;281:871-8.
60. Natural food-fruit vitamin C content. The Natural Food Hub: Available from: http://www.naturalhub.com/natural-food-guide-fruit-vitamin-c.htm, 2001 (cited 24 May 2010).