Anti-angiogenic effect of high doses of ascorbic acid

Journal of Translational Medicine

Volumn 6, Issue , 2008, Pages

  Mikirova, Nina A ^a   Ichim, Thomas E ^b   Riordan, Neil H ^b  

^a Bio Communications Research Institute   (United States)

^b Medistem Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; MATRIGEL; NITRIC OXIDE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; COLLAGEN; LAMININ; N(G) NITROARGININE METHYL ESTER; PROTEOGLYCAN;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINE; CELL MIGRATION; CELL SEPARATION; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MEGADOSE; ENDOTHELIUM CELL; ENERGY METABOLISM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PERIPHERAL BLOOD STEM CELL; UMBILICAL ARTERY; UMBILICAL VEIN; WOUND HEALING; ANGIOGENESIS; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMBINATION; DRUG EFFECT; METABOLISM; STEM CELL; UMBILICAL CORD;

ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; CELL MOVEMENT; CELL SEPARATION; CELLS, CULTURED; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIAL CELLS; HUMANS; LAMININ; NEOVASCULARIZATION, PHYSIOLOGIC; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PROTEOGLYCANS; STEM CELLS; UMBILICAL CORD;

EID: 53549096517     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-6-50     Document Type: Article

References (46)

1. Duconge J Miranda-Massari JR Gonzalez MJ Jackson JA Warnock W Riordan NH Pharmacokinetics of vitamin C: Insights into the oral and intravenous administration of ascorbate P R Health Sci J 2008, 27(1):7-19 18450228
2. Gonzalez MJ Miranda-Massari JR Mora EM Guzman A Riordan NH Riordan HD Casciari JJ Jackson JA Roman-Franco A Orthomolecular oncology review: Ascorbic acid and cancer 25 years later Integrative cancer therapies 2005, 4(1):32-44 10.1177/1534735404273861 15695476
3. Peterkofsky B Prather W Cytotoxicity of ascorbate and other reducing agents towards cultured fibroblasts as a result of hydrogen peroxide formation J Cell Physiol 1977, 90:61-70 10.1002/jcp.1040900109 833212
4. Jampel HD Ascorbic acid is cytotoxic to dividing human tenon's capsule fibroblasts Arch Ophthalmol 1990, 108(9):1323-1325 2095758
5. Arakama N Nemoto S Suzuki E Otsuka M Role of hydrogen peroxide in the inhibitory effect of ascorbate on cell growth J Nutr Sci Vitaminol 1994, 40:219-227 7965211
6. Casciari JJ Riordan NH Schmidt TL Meng XL Jackson JA Riordan HD Cytotoxicity of ascorbate, lipoic acid and other antioxidants in hollow fiber in vitro tumors Br J Cancer 2001, 84:1544-1550 10.1054/ bjoc.2001.1814 11384106
7. Chen Qi Espey MG Krishna MC Mitchel JB Copre CP Buettner GR Shacter E Levine M Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissue PNAS 2005, 102(38):13604-13609 1224653 16157892 10.1073/pnas.0506390102
8. Clement MV Ramalingam J Long LH Hallwell B The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide Antioxidants and redox signaling 2001, 3(1):157-162 10.1089/152308601750100687 11291594
9. Sestili R Brandi G Bramilla L Cattabeni F Cantoni O Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: Cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts The Journal of Pharmacology and experimental therapeutics 1996, 277:11719-1725
10. Mikirova NA Jackson JA Riordan NH The effect of high dose IV vitamin C on plasma antioxidant capacity and level of oxidative stress in cancer patients and healthy volunteers JOM 2007, 22(3):153-160
11. Riordan NH Riordan HD Jackson JA Casciari JP Clinical and experimental experiences with intravenous vitamin C Journal of Orthomolecular Medicine 2000, 15(4):201-213
12. Riordan HD Jackson JA Riordan NH High-dose intravenous vitamin C in the treatment of patients with renal carcinoma of the kidney J Orthomolecular Med 1998, 13:72-3
13. Riordan HD Riordan NH Jackson JA Casciari JJ Hunninghake R Gonzalez MJ Mora EM Miranda-Massari JR Rosario N Rivera A Intravenous vitamin C as a chemotherapy agent: A report on clinical cases P R Health Sci J 2004, 23(2):115-118 15377059
14. Jackson JA Riordan HD Hunninghake RE Riordan NH High-dose intravenous vitamin C and long-time survival of patients with cancer of the head and pancreas J Orthomol Med 1995, 10:87-8
15. Riordan NH Jackson JA Riordan HD Intravenous vitamin C in a terminal cancer patient J Orthomol Med 1996, 11:80-2
16. Padayatty SJ Riordan HD Hewitt SM Katz A Hoffer LJ Levine M Intravenously administered vitamin C as cancer therapy: Three cases CMAJ 2006, 174(7):937-42 1405876 16567755
17. Yeom Hwan Chang Jung Chul Gyou Song Jeong Keun Changes of the terminal cancer patients' health-related quality of life after high dose vitamin C administration J Korean Med Sci 2007, 22:7-11 17297243
18. Du WD Yuan ZR Sun J Tang JX Cheng AO Shen DM Huang CJ Song XH Yu XF Zheng SB Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanism World Journal of gastroenterology 2003, 9(11):2565-2569 14606098
19. Bagley RG Walter-Yohrling J Cao X Weber W Simons B Cook BP Chartrand SD Wang C Madden SL Endothelial precursor cells as a model of tumor endothelium: Characterization and comparison with mature endothelial cells Cancer research 2003, 63:5866-5873 14522911
20. Peichev M Naiyer A Pereira D Zhu Z Lane WJ Williams M Oz MC Hicklin DJ Witte L Moore MA Rafii S Expression of VEGFR2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors Blood 2000, 95:952-958 10648408
21. Gill M Dias S Hattori K Rivera M Hicklin D Witte L Girardi L Yurt R Himel H Rafii S Vascular trauma induced rapid but transient mobilization of VEGFR2+AC133+ endothelial precursor cells Circ Res 2001, 88:167-174 11157668
22. Lyden D Hattori k Dias S Costa C Blaikie P Butros L Chadburn A Heissiq B Marks W Witte L Wu Y Hicklin D Zhu Z Hackett NR Crystal RG Moore MA Hajjar KA Manova K Benezra R Rafii S Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth Nat Med 2001, 7:1194-1201 10.1038/ nm1101-1194 11689883
23. Barley R Weber W Rouleau C Teicher BA Pericytes and endothelial precursor cells: Cellular interactions and contributions to malignancy Cancer Res 2005, 65(21):9741-9750 10.1158/0008-5472.CAN-04-4337 16266995
24. Asahara T Masuda H Takahashi T Kalka C Pastore C Silver M Kearne M magner M Isner JM Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization Circ Res 1999, 85:221-8 10436164
25. Orimo A Gupta PB Sgroi DC Arenzana-Seisdedos F Delaunay T Naeem R Garey VJ Richardson AL Weinberg RA Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion Cell 2005, 121:335-348 10.1016/ j.cell.2005.02.034 15882617
26. Bompais H Chagraoui J Canron X Crisan M Liu XH Anjo A Port CT Leboeuf M Charbord P Bikfalvi A Uzan G Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells Blood 2004, 103:2577-2584 10.1182/blood-2003-08-2770 14630797
27. Rajantie I Ilmonen M Alminaite A Ozerdem U Alitalo K Salven P Adult bone-marrow derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells Blood 2004, 104:2084-2086 10.1182/blood-2004-01-0336 15191949
28. De Palma M Venneri MA Roca C Naldini L Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells Nat Med 2003, 9:789-795 10.1038/nm871 12740570
29. Conejo-Garcia JR Benencia F Courreges MC Mohamed-Hodley A Buckanovich RJ Holtz DO Jenkins A Na H Zhang L Wagner DS Katsaros D Caroll R Coukos G Tumor-infiltrating dendritic cells precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A Nat Med 2004, 10:950-958 10.1038/nm1097 15334073
30. Yang L deBusk LM Fukuda K Fingleto B Green-Jarvis B Shyr Y Matrisian LM Carbone DP Lin PC Expansion of myeloid immune suppressor Gr+CD11+ cells in tumor-bearing host directly promotes tumor angiogenesis Cancer cell 2004, 6:409-421 10.1016/j.ccr.2004.08.031 15488763
31. Grant MB May WS Caballero S Brown GA Guthrie SM Mames RN Byrne BJ Vaught T Spoerri PE Peck AB Scott EW Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization Nat med 2002, 8:607-612 10.1038/nm0602-607 12042812
32. Direkze NC Hodivala-Dilke K Jeffery R Hunt T Poulsom R Oukrif D Alison MR Wright NA Bone marrow contribution to tumor associated myofibroblasts and fibroblasts Cancer Res 2004, 64:8492-8495 10.1158/ 0008-5472.CAN-04-1708 15574751
33. Telang S Clem AL Eaton JW Chesney J Depletion of ascorbic acid restricts angiogenesis and retards tumor growth in a mouse model Neoplasia 2007, 9:47-56 1804324 17325743 10.1593/neo.06664
34. Parsons KK Maeda N Yamauchi M Banes AJ Koller BH Ascorbic-acid - independent synthesis of collagen in mice Am J Physiol Endocrinol Metab 2006, 290:E1131-1139 10.1152/ajpendo.00339.2005 16352673
35. Peyman GA Kivilcim M Dellacroce JT Munoz Morales A Inhibition of Corneal Neovascularization by Ascorbic Acid in Rat Model [abstract] Graefes Arch Clin Exp Ophthalmol 2007, 245(10):1461-1467 10.1007/s00417-007-0542-4 17318569
36. Tamalarasan KP Kolluru GK Rajaram M Indhumathy M Saranya R Chatterjee S Thalidomide attaenuates nitric oxide mediated angiogenesis by blocking migration of endothelila cells BMC cell Biology 2006, 7:17-30 1456963 16584574 10.1186/1471-2121-7-17
37. Lin YI Weisdorf DJ Solovey A Hebbel RP Origins of circulating endothelial cells and endothelial outgrowth from blood Journal of clinical Investigation 2000, 105(4):71-77 382587 10619863 10.1172/JCI8071
38. Gulati R Jevremovic D Peterson TE Chatterjee S Shah V Vile RG Simari RD Diverse origin and function of cells with endothelila phenotype obtained from adult human blood Circulation Research 2003, 93:1023-1025 10.1161/ 01.RES.0000105569.77539.21 14605020
39. Duda DG Fukumura D Jain RK Role of eNOS in neovascularization: NO for endothelial progenitor cells Trends Mol Med 2004, 10:143-145 10.1016/ j.molmed.2004.02.001 15162796
40. Dulak J Jozkowicz A Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells Arterioscler Thromb Biol 2000, 20:659-666 10712388
41. Gratton JP Lin MI Yu J Weiss ED Jiang ZL Fairchild TA Iwakiri Y Groszmann R Claffey KP Cheng YC Sessa WC Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice Cancer Cell 2003, 4:31-39 10.1016/S1535-6108(03)00168-5 12892711
42. Gallo O Masini E Morbidelli L Franchi A Fini-Storchi I Vergari WA Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer J Natl cancer Inst 1998, 90:584-596 10.1093/jnci/90.8.587 9554441
43. Lorraine JC Lala PK Nitric oxide synthase inhibition by NG-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors Am J Pathol 1999, 155:1381-1390 1867009 10514420
44. Lee PC Salyapongse AN Bragdon GA Shears LL Watkins SC Edington HD Billiar TR Impaired wound healing and angiogenesis in e NOS-deficient mice Am J Physiol 1999, 277:H1600-H1608 10516200
45. Jenkins DC Charles IG Thomsen LL Moss DW Holmes LS Baylis SA Rhodes P Westmore K Emson PC Moncada S Role of nitric oxide in tumor growth Proc Natl Acad Sci 1995, 92:4392-4396 41950 7538668 10.1073/pnas.92.10.4392
46. Gratton J Lin M Yu J Weiss E Jiang ZL Fairchild TA Iwakiri Y Groszmann R Claffey KP Cheng YC Sessa WC Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice Cancer cell 2003, 4:31-39 10.1016/S1535-6108(03)00168-5 12892711