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Volumn 3, Issue 1, 2011, Pages 9-16

From antiangiogenesis to hypoxia: Current research and future directions

Author keywords

Antiangiogenesis; Genetic alteration; Hypoxia; Tumor progression

Indexed keywords

ALPHA2A INTERFERON; ANGIOGENESIS INHIBITOR; ANGIOSTATIN; BASIC FIBROBLAST GROWTH FACTOR; BEVACIZUMAB; ENDOSTATIN; FLUOROURACIL; FOLINIC ACID; FUMAGILLOL CHLOROACETYLCARBAMATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRINOTECAN; MELPHALAN; N ACETYLSARCOSYLGLYCYLVALYL DEXTRO ALLOISOLEUCYLTHREONYLNORVALYLISOLEUCYLARGINYLPROLINE ETHYLAMIDE; OXALIPLATIN; PLACEBO; PREDNISOLONE; SEMAXANIB; THALIDOMIDE; TOPOTECAN; VASCULOTROPIN; VATALANIB;

EID: 79251476288     PISSN: None     EISSN: 11791322     Source Type: Book Series    
DOI: 10.2147/CMR.S14812     Document Type: Review
Times cited : (15)

References (78)
  • 1
    • 0000912662 scopus 로고
    • Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • Ide AG, Baker NH, Warren SL. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. AJR Am J Roentgenol. 1939; 42:891-899.
    • (1939) AJR Am J Roentgenol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 2
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • Algire GH, Chalkley HW. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst. 1945; 6:73-85.
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkley, H.W.2
  • 3
    • 85025418118 scopus 로고
    • Heterologous transplantation of mammalian tumors: I. The transfer of rabbit tumors to alien species
    • Greene HS. Heterologous transplantation of mammalian tumors: I. The transfer of rabbit tumors to alien species. J Exp Med. 1941; 73(4): 461-474.
    • (1941) J Exp Med , vol.73 , Issue.4 , pp. 461-474
    • Greene, H.S.1
  • 4
    • 0013943005 scopus 로고
    • Tumor behavior in isolated perfused organs: In vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment
    • Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg. 1966; 164(3):491-502.
    • (1966) Ann Surg , vol.164 , Issue.3 , pp. 491-502
    • Folkman, J.1    Cole, P.2    Zimmerman, S.3
  • 5
    • 0014664384 scopus 로고
    • Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium
    • Gimbrone MA, Aster RH, Cotran RS, Corkery J, Jandl JH, Folkman J. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature. 1969; 222(5188):33-36.
    • (1969) Nature , vol.222 , Issue.5188 , pp. 33-36
    • Gimbrone, M.A.1    Aster, R.H.2    Cotran, R.S.3    Corkery, J.4    Jandl, J.H.5    Folkman, J.6
  • 6
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21):1182-1186.
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm T, Folkman J, Browder T, O'Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature. 1997; 390(6658):404-407.
    • (1997) Nature , vol.390 , Issue.6658 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 8
    • 84975525035 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • Folkman J. Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 1995; 333(26):1757-1763.
    • (1995) N Engl J Med , vol.333 , Issue.26 , pp. 1757-1763
    • Folkman, J.1
  • 9
    • 0021359304 scopus 로고
    • Heparin affnity: Purification of a tumor-derived capillary endothelial cell growth factor
    • Shing Y, Folkman J, Sullivan R, Butterfeld C, Murray J, Klagsbrun M. Heparin affnity: purification of a tumor-derived capillary endothelial cell growth factor. Science. 1984; 223(4642):1296-1299.
    • (1984) Science , vol.223 , Issue.4642 , pp. 1296-1299
    • Shing, Y.1    Folkman, J.2    Sullivan, R.3    Butterfeld, C.4    Murray, J.5    Klagsbrun, M.6
  • 10
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987; 235(4787): 442-447.
    • (1987) Science , vol.235 , Issue.4787 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 11
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989; 246(4935): 1309-1312.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3
  • 12
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel D V, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246(4935):1306-1309.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 13
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med. 1995; 1(10):1024-1028.
    • (1995) Nat Med , vol.1 , Issue.10 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'er, J.4    Stone, J.5    Keshet, E.6
  • 14
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997; 18(1):4-25.
    • (1997) Endocr Rev , vol.18 , Issue.1 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 15
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • Davis S, Aldrich TH, Jones P F, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996; 87(7):1161-1169.
    • (1996) Cell , vol.87 , Issue.7 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 16
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 1999; 284(5422):1994-1998.
    • (1999) Science , vol.284 , Issue.5422 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 17
    • 0027097806 scopus 로고
    • Interleukin-8 as a macro-phage-derived mediator of angiogenesis
    • Koch AE, Polverini PJ, Kunkel SL, et al. Interleukin-8 as a macro-phage-derived mediator of angiogenesis. Science. 1992; 258(5089): 1798-1801.
    • (1992) Science , vol.258 , Issue.5089 , pp. 1798-1801
    • Koch, A.E.1    Polverini, P.J.2    Kunkel, S.L.3
  • 18
    • 0027052607 scopus 로고
    • Interleukin-8. A corneal factor that induces neovascularization
    • Strieter RM, Kunkel SL, Elner VM, et al. Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol. 1992; 141(6): 1279-1284.
    • (1992) Am J Pathol , vol.141 , Issue.6 , pp. 1279-1284
    • Strieter, R.M.1    Kunkel, S.L.2    Elner, V.M.3
  • 19
    • 0025913891 scopus 로고
    • Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma
    • Kandel J, Bossy-Wetzel E, Radvanyi F, Klagsbrun M, Folkman J, Hanahan D. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell. 1991; 66(6):1095-1104.
    • (1991) Cell , vol.66 , Issue.6 , pp. 1095-1104
    • Kandel, J.1    Bossy-Wetzel, E.2    Radvanyi, F.3    Klagsbrun, M.4    Folkman, J.5    Hanahan, D.6
  • 20
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86(3):353-364.
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 22
    • 0035498677 scopus 로고    scopus 로고
    • Phase II study of the antian-giogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Tseng JE, Glisson BS, Khuri FR, et al. Phase II study of the antian-giogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck. Cancer. 2001; 92(9):2364-2373.
    • (2001) Cancer , vol.92 , Issue.9 , pp. 2364-2373
    • Tseng, J.E.1    Glisson, B.S.2    Khuri, F.R.3
  • 23
    • 0034783270 scopus 로고    scopus 로고
    • A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer
    • Figg WD, Dahut W, Duray P, et al. A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. Clin Cancer Res. 2001; 7(7):1888-1893.
    • (2001) Clin Cancer Res , vol.7 , Issue.7 , pp. 1888-1893
    • Figg, W.D.1    Dahut, W.2    Duray, P.3
  • 24
    • 0032767386 scopus 로고    scopus 로고
    • Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma
    • Stadler WM, Kuzel T, Shapiro C, Sosman J, Clark J, Vogelzang NJ. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J Clin Oncol. 1999; 17(8):2541-2545.
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2541-2545
    • Stadler, W.M.1    Kuzel, T.2    Shapiro, C.3    Sosman, J.4    Clark, J.5    Vogelzang, N.J.6
  • 25
    • 0034901968 scopus 로고    scopus 로고
    • Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer
    • Logothetis CJ, Wu KK, Finn LD, et al. Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer. Clin Cancer Res. 2001; 7(5):1198-1203.
    • (2001) Clin Cancer Res , vol.7 , Issue.5 , pp. 1198-1203
    • Logothetis, C.J.1    Wu, K.K.2    Finn, L.D.3
  • 26
    • 0027970092 scopus 로고
    • Angiostatin: A novel angio-genesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angio-genesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994; 79(2):315-328.
    • (1994) Cell , vol.79 , Issue.2 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 27
    • 0141678926 scopus 로고    scopus 로고
    • Recombinant human angiostatin by twice-daily subcutaneous injection in advanced cancer: A pharmacokinetic and long-term safety study
    • Beerepoot LV, Witteveen EO, Groenewegen G, et al. Recombinant human angiostatin by twice-daily subcutaneous injection in advanced cancer: a pharmacokinetic and long-term safety study. Clin Cancer Res. 2003; 9(11):4025-4033.
    • (2003) Clin Cancer Res , vol.9 , Issue.11 , pp. 4025-4033
    • Beerepoot, L.V.1    Witteveen, E.O.2    Groenewegen, G.3
  • 28
    • 24344488390 scopus 로고    scopus 로고
    • In vivo generation of angiosta-tin isoforms by administration of a plasminogen activator and a free sulfhydryl donor: A phase I study of an angiostatic cocktail of tissue plasminogen activator and mesna
    • Soff GA, Wang H, Cundiff DL, et al. In vivo generation of angiosta-tin isoforms by administration of a plasminogen activator and a free sulfhydryl donor: a phase I study of an angiostatic cocktail of tissue plasminogen activator and mesna. Clin Cancer Res. 2005; 11(17): 6218-6225.
    • (2005) Clin Cancer Res , vol.11 , Issue.17 , pp. 6218-6225
    • Soff, G.A.1    Wang, H.2    Cundiff, D.L.3
  • 29
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997; 88(2): 277-285.
    • (1997) Cell , vol.88 , Issue.2 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 30
    • 0037106261 scopus 로고    scopus 로고
    • Phase I study of recombinant human endostatin in patients with advanced solid tumors
    • Herbst RS, Hess KR, Tran HT, et al. Phase I study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol. 2002; 20(18):3792-3803.
    • (2002) J Clin Oncol , vol.20 , Issue.18 , pp. 3792-3803
    • Herbst, R.S.1    Hess, K.R.2    Tran, H.T.3
  • 31
    • 33747072903 scopus 로고    scopus 로고
    • Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
    • Kulke MH, Bergsland EK, Ryan D P, et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors. J Clin Oncol. 2006; 24(22):3555-3561.
    • (2006) J Clin Oncol , vol.24 , Issue.22 , pp. 3555-3561
    • Kulke, M.H.1    Bergsland, E.K.2    Ryan, D.P.3
  • 32
    • 34249990658 scopus 로고    scopus 로고
    • A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma
    • Markovic SN, Suman VJ, Rao RA, et al. A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma. Am J Clin Oncol. 2007; 30(3):303-309.
    • (2007) Am J Clin Oncol , vol.30 , Issue.3 , pp. 303-309
    • Markovic, S.N.1    Suman, V.J.2    Rao, R.A.3
  • 33
    • 57149111052 scopus 로고    scopus 로고
    • Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
    • Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol. 2008; 26(34):5583-5588.
    • (2008) J Clin Oncol , vol.26 , Issue.34 , pp. 5583-5588
    • Baker, L.H.1    Rowinsky, E.K.2    Mendelson, D.3
  • 34
    • 33845874370 scopus 로고    scopus 로고
    • A phase II study of SU5416 in patients with advanced or recurrent head and neck cancers
    • Fury MG, Zahalsky A, Wong R, et al. A phase II study of SU5416 in patients with advanced or recurrent head and neck cancers. Invest New Drugs. 2007; 25(2):165-172.
    • (2007) Invest New Drugs , vol.25 , Issue.2 , pp. 165-172
    • Fury, M.G.1    Zahalsky, A.2    Wong, R.3
  • 35
    • 33744482540 scopus 로고    scopus 로고
    • Phase 1study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
    • Roboz GJ, Giles FJ, List A F, et al. Phase 1study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia. 2006; 20(6):952-957.
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 952-957
    • Roboz, G.J.1    Giles, F.J.2    List, A.F.3
  • 36
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of beva-cizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of beva-cizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003; 349(5):427-434.
    • (2003) N Engl J Med , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 37
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus iri-notecan, fuorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus iri-notecan, fuorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004; 350(23):2335-2342.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 38
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of beva-cizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of beva-cizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol. 2009; 27(13):2231-2237.
    • (2009) J Clin Oncol , vol.27 , Issue.13 , pp. 2231-2237
    • van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 39
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as frst-line therapy in meta-static colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as frst-line therapy in meta-static colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26(12):2013-2019.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 40
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007; 357(26):2666-2676.
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 41
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Fnal analysis of overall survival
    • Escudier B, Bellmunt J, Negrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): fnal analysis of overall survival. J Clin Oncol. 2010; 28(13):2144-2150.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2144-2150
    • Escudier, B.1    Bellmunt, J.2    Negrier, S.3
  • 42
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fuorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fuorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007; 25(12):1539-1544.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 43
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006; 355(24):2542-2550.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 44
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fuorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fuorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 2005; 23(16):3706-3712.
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 45
    • 34848833957 scopus 로고    scopus 로고
    • Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial
    • Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet. 2007; 370(9594):1209-1218.
    • (2007) Lancet , vol.370 , Issue.9594 , pp. 1209-1218
    • Facon, T.1    Mary, J.Y.2    Hulin, C.3
  • 46
    • 0032748385 scopus 로고    scopus 로고
    • Antitumor activity of thalido-mide in refractory multiple myeloma
    • Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalido-mide in refractory multiple myeloma. N Engl J Med. 1999; 341(21): 1565-1571.
    • (1999) N Engl J Med , vol.341 , Issue.21 , pp. 1565-1571
    • Singhal, S.1    Mehta, J.2    Desikan, R.3
  • 47
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee CG, Heijn M, di Tomaso E, et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000; 60(19):5565-5570.
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5565-5570
    • Lee, C.G.1    Heijn, M.2    di Tomaso, E.3
  • 48
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005; 307(5706):58-62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 49
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: Novel insights through intravital imaging in pre-clinical models
    • Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010; 17(3):206-225.
    • (2010) Microcirculation , vol.17 , Issue.3 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 50
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005; 8(4):299-309.
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 51
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008; 8(8):579-591.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 52
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; 3(10):721-732.
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 53
    • 0035476509 scopus 로고    scopus 로고
    • Induction of hypervascu-larity without leakage or inflammation in transgenic mice overex-pressing hypoxia-inducible factor-1alpha
    • Elson DA, Thurston G, Huang LE, et al. Induction of hypervascu-larity without leakage or inflammation in transgenic mice overex-pressing hypoxia-inducible factor-1alpha. Genes Dev. 2001; 15(19): 2520-2532.
    • (2001) Genes Dev , vol.15 , Issue.19 , pp. 2520-2532
    • Elson, D.A.1    Thurston, G.2    Huang, L.E.3
  • 54
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009; 136(5):839-851.
    • (2009) Cell , vol.136 , Issue.5 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    de Oliveira, R.L.3
  • 55
    • 0347378566 scopus 로고    scopus 로고
    • Invasion as limitation to anti-angiogenic glioma therapy
    • Lamszus K, Kunkel P, Westphal M. Invasion as limitation to anti-angiogenic glioma therapy. Acta Neurochir Suppl. 2003; 88:169-177.
    • (2003) Acta Neurochir Suppl , vol.88 , pp. 169-177
    • Lamszus, K.1    Kunkel, P.2    Westphal, M.3
  • 56
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008; 8(8):592-603.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 57
    • 68049093213 scopus 로고    scopus 로고
    • Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy
    • Lucio-Eterovic AK, Piao Y, de Groot JF. Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy. Clin Cancer Res. 2009; 15(14):4589-4599.
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4589-4599
    • Lucio-Eterovic, A.K.1    Piao, Y.2    de Groot, J.F.3
  • 58
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009; 15(3):220-231.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 59
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009; 15(3): 232-239.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 60
    • 41649112610 scopus 로고    scopus 로고
    • Bevacizumab for recurrent malignant gliomas: Effcacy, toxicity, and patterns of recurrence
    • Norden AD, Young GS, Setayesh K, et al. Bevacizumab for recurrent malignant gliomas: effcacy, toxicity, and patterns of recurrence. Neurolog y. 2008; 70(10):779-787.
    • (2008) Neurolog Y , vol.70 , Issue.10 , pp. 779-787
    • Norden, A.D.1    Young, G.S.2    Setayesh, K.3
  • 61
    • 74049090120 scopus 로고    scopus 로고
    • Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
    • Verhoeff JJ, van Tellingen O, Claes A, et al. Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme. BMC Cancer. 2009; 9:444.
    • (2009) BMC Cancer , vol.9 , pp. 444
    • Verhoeff, J.J.1    van Tellingen, O.2    Claes, A.3
  • 62
    • 57149142495 scopus 로고    scopus 로고
    • 2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008; 8(12):967-975.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 63
    • 0037490210 scopus 로고    scopus 로고
    • Hypoxia-inducible factor and its biomedical relevance
    • Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem. 2003; 278(22):19575-19578.
    • (2003) J Biol Chem , vol.278 , Issue.22 , pp. 19575-19578
    • Huang, L.E.1    Bunn, H.F.2
  • 64
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008; 30(4): 393-402.
    • (2008) Mol Cell , vol.30 , Issue.4 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 65
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer. 2002; 2(1):38-47.
    • (2002) Nat Rev Cancer , vol.2 , Issue.1 , pp. 38-47
    • Harris, A.L.1
  • 66
    • 33846697957 scopus 로고    scopus 로고
    • Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression
    • Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression. J Mol Med. 2007; 85(2):139-148.
    • (2007) J Mol Med , vol.85 , Issue.2 , pp. 139-148
    • Huang, L.E.1    Bindra, R.S.2    Glazer, P.M.3    Harris, A.L.4
  • 67
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG, Hill R P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 2008; 8(3):180-192.
    • (2008) Nat Rev Cancer , vol.8 , Issue.3 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 68
    • 40949108800 scopus 로고    scopus 로고
    • Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation
    • Huang LE. Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation. Cell Death Differ. 2008(4); 15:672-677.
    • (2008) Cell Death Differ , vol.15 , Issue.4 , pp. 672-677
    • Huang, L.E.1
  • 69
    • 56849096837 scopus 로고    scopus 로고
    • HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-defcient clear cell renal carcinoma
    • Gordan JD, Lal P, Dondeti VR, et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-defcient clear cell renal carcinoma. Cancer Cell. 2008; 14(6):435-446.
    • (2008) Cancer Cell , vol.14 , Issue.6 , pp. 435-446
    • Gordan, J.D.1    Lal, P.2    Dondeti, V.R.3
  • 70
    • 15244344206 scopus 로고    scopus 로고
    • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
    • Koshiji M, To KK, Hammer S, et al. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell. 2005; 17(6):793-803.
    • (2005) Mol Cell , vol.17 , Issue.6 , pp. 793-803
    • Koshiji, M.1    To, K.K.2    Hammer, S.3
  • 71
    • 33750202279 scopus 로고    scopus 로고
    • The phos-phorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
    • To KK, Sedelnikova OA, Samons M, Bonner WM, Huang LE. The phos-phorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J. 2006; 25(20):4784-4794.
    • (2006) EMBO J , vol.25 , Issue.20 , pp. 4784-4794
    • To, K.K.1    Sedelnikova, O.A.2    Samons, M.3    Bonner, W.M.4    Huang, L.E.5
  • 72
  • 73
    • 79951820679 scopus 로고    scopus 로고
    • HIF-1α confers aggressive malignant traits on human tumor cells independent of its canonical transcriptional function
    • (In press)
    • Yoo YG, Christensen J, Huang LE. HIF-1α confers aggressive malignant traits on human tumor cells independent of its canonical transcriptional function. Cancer Res. (In press).
    • Cancer Res
    • Yoo, Y.G.1    Christensen, J.2    Huang, L.E.3
  • 74
    • 25444432052 scopus 로고    scopus 로고
    • Genetic instability: The dark side of the hypoxic response
    • To KK, Koshiji M, Hammer S, Huang LE. Genetic instability: the dark side of the hypoxic response. Cell Cycle. 2005; 4(7):881-882.
    • (2005) Cell Cycle , vol.4 , Issue.7 , pp. 881-882
    • To, K.K.1    Koshiji, M.2    Hammer, S.3    Huang, L.E.4
  • 75
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival beneft in a mouse model of cancer
    • Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival beneft in a mouse model of cancer. J Clin Oncol. 2005; 23(5):939-952.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 76
    • 33749362031 scopus 로고    scopus 로고
    • Inhibiting hypoxia-inducible factor 1 for cancer therapy
    • Melillo G. Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res. 2006; 4(9):601-605.
    • (2006) Mol Cancer Res , vol.4 , Issue.9 , pp. 601-605
    • Melillo, G.1
  • 77
    • 1242271198 scopus 로고    scopus 로고
    • Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
    • Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004; 64(4):1475-1482.
    • (2004) Cancer Res , vol.64 , Issue.4 , pp. 1475-1482
    • Rapisarda, A.1    Uranchimeg, B.2    Sordet, O.3    Pommier, Y.4    Shoemaker, R.H.5    Melillo, G.6
  • 78
    • 67651166780 scopus 로고    scopus 로고
    • Increased antitu-mor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
    • Rapisarda A, Hollingshead M, Uranchimeg B, et al. Increased antitu-mor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther. 2009; 8(7):1867-1877.
    • (2009) Mol Cancer Ther , vol.8 , Issue.7 , pp. 1867-1877
    • Rapisarda, A.1    Hollingshead, M.2    Uranchimeg, B.3


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