-
1
-
-
0000912662
-
Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
-
Ide AG, Baker NH, Warren SL. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. AJR Am J Roentgenol. 1939; 42:891-899.
-
(1939)
AJR Am J Roentgenol
, vol.42
, pp. 891-899
-
-
Ide, A.G.1
Baker, N.H.2
Warren, S.L.3
-
2
-
-
84959830787
-
Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
-
Algire GH, Chalkley HW. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst. 1945; 6:73-85.
-
(1945)
J Natl Cancer Inst
, vol.6
, pp. 73-85
-
-
Algire, G.H.1
Chalkley, H.W.2
-
3
-
-
85025418118
-
Heterologous transplantation of mammalian tumors: I. The transfer of rabbit tumors to alien species
-
Greene HS. Heterologous transplantation of mammalian tumors: I. The transfer of rabbit tumors to alien species. J Exp Med. 1941; 73(4): 461-474.
-
(1941)
J Exp Med
, vol.73
, Issue.4
, pp. 461-474
-
-
Greene, H.S.1
-
4
-
-
0013943005
-
Tumor behavior in isolated perfused organs: In vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment
-
Folkman J, Cole P, Zimmerman S. Tumor behavior in isolated perfused organs: in vitro growth and metastases of biopsy material in rabbit thyroid and canine intestinal segment. Ann Surg. 1966; 164(3):491-502.
-
(1966)
Ann Surg
, vol.164
, Issue.3
, pp. 491-502
-
-
Folkman, J.1
Cole, P.2
Zimmerman, S.3
-
5
-
-
0014664384
-
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium
-
Gimbrone MA, Aster RH, Cotran RS, Corkery J, Jandl JH, Folkman J. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature. 1969; 222(5188):33-36.
-
(1969)
Nature
, vol.222
, Issue.5188
, pp. 33-36
-
-
Gimbrone, M.A.1
Aster, R.H.2
Cotran, R.S.3
Corkery, J.4
Jandl, J.H.5
Folkman, J.6
-
6
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285(21):1182-1186.
-
(1971)
N Engl J Med
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
7
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T, Folkman J, Browder T, O'Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature. 1997; 390(6658):404-407.
-
(1997)
Nature
, vol.390
, Issue.6658
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
8
-
-
84975525035
-
Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
-
Folkman J. Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 1995; 333(26):1757-1763.
-
(1995)
N Engl J Med
, vol.333
, Issue.26
, pp. 1757-1763
-
-
Folkman, J.1
-
9
-
-
0021359304
-
Heparin affnity: Purification of a tumor-derived capillary endothelial cell growth factor
-
Shing Y, Folkman J, Sullivan R, Butterfeld C, Murray J, Klagsbrun M. Heparin affnity: purification of a tumor-derived capillary endothelial cell growth factor. Science. 1984; 223(4642):1296-1299.
-
(1984)
Science
, vol.223
, Issue.4642
, pp. 1296-1299
-
-
Shing, Y.1
Folkman, J.2
Sullivan, R.3
Butterfeld, C.4
Murray, J.5
Klagsbrun, M.6
-
10
-
-
0023157363
-
Angiogenic factors
-
Folkman J, Klagsbrun M. Angiogenic factors. Science. 1987; 235(4787): 442-447.
-
(1987)
Science
, vol.235
, Issue.4787
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
11
-
-
0024801035
-
Vascular permeability factor, an endothelial cell mitogen related to PDGF
-
Keck PJ, Hauser SD, Krivi G, et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989; 246(4935): 1309-1312.
-
(1989)
Science
, vol.246
, Issue.4935
, pp. 1309-1312
-
-
Keck, P.J.1
Hauser, S.D.2
Krivi, G.3
-
12
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang WJ, Goeddel D V, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246(4935):1306-1309.
-
(1989)
Science
, vol.246
, Issue.4935
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
Goeddel, D.V.4
Ferrara, N.5
-
13
-
-
0028803509
-
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
-
Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med. 1995; 1(10):1024-1028.
-
(1995)
Nat Med
, vol.1
, Issue.10
, pp. 1024-1028
-
-
Alon, T.1
Hemo, I.2
Itin, A.3
Pe'er, J.4
Stone, J.5
Keshet, E.6
-
14
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev. 1997; 18(1):4-25.
-
(1997)
Endocr Rev
, vol.18
, Issue.1
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
15
-
-
0030460424
-
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
-
Davis S, Aldrich TH, Jones P F, et al. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell. 1996; 87(7):1161-1169.
-
(1996)
Cell
, vol.87
, Issue.7
, pp. 1161-1169
-
-
Davis, S.1
Aldrich, T.H.2
Jones, P.F.3
-
16
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 1999; 284(5422):1994-1998.
-
(1999)
Science
, vol.284
, Issue.5422
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
-
17
-
-
0027097806
-
Interleukin-8 as a macro-phage-derived mediator of angiogenesis
-
Koch AE, Polverini PJ, Kunkel SL, et al. Interleukin-8 as a macro-phage-derived mediator of angiogenesis. Science. 1992; 258(5089): 1798-1801.
-
(1992)
Science
, vol.258
, Issue.5089
, pp. 1798-1801
-
-
Koch, A.E.1
Polverini, P.J.2
Kunkel, S.L.3
-
18
-
-
0027052607
-
Interleukin-8. A corneal factor that induces neovascularization
-
Strieter RM, Kunkel SL, Elner VM, et al. Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol. 1992; 141(6): 1279-1284.
-
(1992)
Am J Pathol
, vol.141
, Issue.6
, pp. 1279-1284
-
-
Strieter, R.M.1
Kunkel, S.L.2
Elner, V.M.3
-
19
-
-
0025913891
-
Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma
-
Kandel J, Bossy-Wetzel E, Radvanyi F, Klagsbrun M, Folkman J, Hanahan D. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell. 1991; 66(6):1095-1104.
-
(1991)
Cell
, vol.66
, Issue.6
, pp. 1095-1104
-
-
Kandel, J.1
Bossy-Wetzel, E.2
Radvanyi, F.3
Klagsbrun, M.4
Folkman, J.5
Hanahan, D.6
-
20
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86(3):353-364.
-
(1996)
Cell
, vol.86
, Issue.3
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
21
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci U S A. 1994; 91(9): 4082-4085.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.9
, pp. 4082-4085
-
-
D'amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
22
-
-
0035498677
-
Phase II study of the antian-giogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Tseng JE, Glisson BS, Khuri FR, et al. Phase II study of the antian-giogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck. Cancer. 2001; 92(9):2364-2373.
-
(2001)
Cancer
, vol.92
, Issue.9
, pp. 2364-2373
-
-
Tseng, J.E.1
Glisson, B.S.2
Khuri, F.R.3
-
23
-
-
0034783270
-
A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer
-
Figg WD, Dahut W, Duray P, et al. A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. Clin Cancer Res. 2001; 7(7):1888-1893.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.7
, pp. 1888-1893
-
-
Figg, W.D.1
Dahut, W.2
Duray, P.3
-
24
-
-
0032767386
-
Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma
-
Stadler WM, Kuzel T, Shapiro C, Sosman J, Clark J, Vogelzang NJ. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J Clin Oncol. 1999; 17(8):2541-2545.
-
(1999)
J Clin Oncol
, vol.17
, Issue.8
, pp. 2541-2545
-
-
Stadler, W.M.1
Kuzel, T.2
Shapiro, C.3
Sosman, J.4
Clark, J.5
Vogelzang, N.J.6
-
25
-
-
0034901968
-
Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer
-
Logothetis CJ, Wu KK, Finn LD, et al. Phase I trial of the angiogenesis inhibitor TNP-470 for progressive androgen-independent prostate cancer. Clin Cancer Res. 2001; 7(5):1198-1203.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.5
, pp. 1198-1203
-
-
Logothetis, C.J.1
Wu, K.K.2
Finn, L.D.3
-
26
-
-
0027970092
-
Angiostatin: A novel angio-genesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angio-genesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994; 79(2):315-328.
-
(1994)
Cell
, vol.79
, Issue.2
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
-
27
-
-
0141678926
-
Recombinant human angiostatin by twice-daily subcutaneous injection in advanced cancer: A pharmacokinetic and long-term safety study
-
Beerepoot LV, Witteveen EO, Groenewegen G, et al. Recombinant human angiostatin by twice-daily subcutaneous injection in advanced cancer: a pharmacokinetic and long-term safety study. Clin Cancer Res. 2003; 9(11):4025-4033.
-
(2003)
Clin Cancer Res
, vol.9
, Issue.11
, pp. 4025-4033
-
-
Beerepoot, L.V.1
Witteveen, E.O.2
Groenewegen, G.3
-
28
-
-
24344488390
-
In vivo generation of angiosta-tin isoforms by administration of a plasminogen activator and a free sulfhydryl donor: A phase I study of an angiostatic cocktail of tissue plasminogen activator and mesna
-
Soff GA, Wang H, Cundiff DL, et al. In vivo generation of angiosta-tin isoforms by administration of a plasminogen activator and a free sulfhydryl donor: a phase I study of an angiostatic cocktail of tissue plasminogen activator and mesna. Clin Cancer Res. 2005; 11(17): 6218-6225.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.17
, pp. 6218-6225
-
-
Soff, G.A.1
Wang, H.2
Cundiff, D.L.3
-
29
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997; 88(2): 277-285.
-
(1997)
Cell
, vol.88
, Issue.2
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
-
30
-
-
0037106261
-
Phase I study of recombinant human endostatin in patients with advanced solid tumors
-
Herbst RS, Hess KR, Tran HT, et al. Phase I study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol. 2002; 20(18):3792-3803.
-
(2002)
J Clin Oncol
, vol.20
, Issue.18
, pp. 3792-3803
-
-
Herbst, R.S.1
Hess, K.R.2
Tran, H.T.3
-
31
-
-
33747072903
-
Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
-
Kulke MH, Bergsland EK, Ryan D P, et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors. J Clin Oncol. 2006; 24(22):3555-3561.
-
(2006)
J Clin Oncol
, vol.24
, Issue.22
, pp. 3555-3561
-
-
Kulke, M.H.1
Bergsland, E.K.2
Ryan, D.P.3
-
32
-
-
34249990658
-
A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma
-
Markovic SN, Suman VJ, Rao RA, et al. A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma. Am J Clin Oncol. 2007; 30(3):303-309.
-
(2007)
Am J Clin Oncol
, vol.30
, Issue.3
, pp. 303-309
-
-
Markovic, S.N.1
Suman, V.J.2
Rao, R.A.3
-
33
-
-
57149111052
-
Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma
-
Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced soft tissue sarcoma. J Clin Oncol. 2008; 26(34):5583-5588.
-
(2008)
J Clin Oncol
, vol.26
, Issue.34
, pp. 5583-5588
-
-
Baker, L.H.1
Rowinsky, E.K.2
Mendelson, D.3
-
34
-
-
33845874370
-
A phase II study of SU5416 in patients with advanced or recurrent head and neck cancers
-
Fury MG, Zahalsky A, Wong R, et al. A phase II study of SU5416 in patients with advanced or recurrent head and neck cancers. Invest New Drugs. 2007; 25(2):165-172.
-
(2007)
Invest New Drugs
, vol.25
, Issue.2
, pp. 165-172
-
-
Fury, M.G.1
Zahalsky, A.2
Wong, R.3
-
35
-
-
33744482540
-
Phase 1study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
-
Roboz GJ, Giles FJ, List A F, et al. Phase 1study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia. 2006; 20(6):952-957.
-
(2006)
Leukemia
, vol.20
, Issue.6
, pp. 952-957
-
-
Roboz, G.J.1
Giles, F.J.2
List, A.F.3
-
36
-
-
0042343801
-
A randomized trial of beva-cizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of beva-cizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003; 349(5):427-434.
-
(2003)
N Engl J Med
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
37
-
-
2542561964
-
Bevacizumab plus iri-notecan, fuorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus iri-notecan, fuorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004; 350(23):2335-2342.
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
38
-
-
65549150854
-
Phase III trial of beva-cizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
-
van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of beva-cizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol. 2009; 27(13):2231-2237.
-
(2009)
J Clin Oncol
, vol.27
, Issue.13
, pp. 2231-2237
-
-
van Cutsem, E.1
Vervenne, W.L.2
Bennouna, J.3
-
39
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as frst-line therapy in meta-static colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as frst-line therapy in meta-static colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26(12):2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
40
-
-
37549040613
-
Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
-
Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007; 357(26):2666-2676.
-
(2007)
N Engl J Med
, vol.357
, Issue.26
, pp. 2666-2676
-
-
Miller, K.1
Wang, M.2
Gralow, J.3
-
41
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Fnal analysis of overall survival
-
Escudier B, Bellmunt J, Negrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): fnal analysis of overall survival. J Clin Oncol. 2010; 28(13):2144-2150.
-
(2010)
J Clin Oncol
, vol.28
, Issue.13
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Negrier, S.3
-
42
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fuorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fuorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007; 25(12):1539-1544.
-
(2007)
J Clin Oncol
, vol.25
, Issue.12
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
-
43
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006; 355(24):2542-2550.
-
(2006)
N Engl J Med
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
44
-
-
20544471876
-
Combined analysis of efficacy: The addition of bevacizumab to fuorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
-
Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fuorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 2005; 23(16):3706-3712.
-
(2005)
J Clin Oncol
, vol.23
, Issue.16
, pp. 3706-3712
-
-
Kabbinavar, F.F.1
Hambleton, J.2
Mass, R.D.3
Hurwitz, H.I.4
Bergsland, E.5
Sarkar, S.6
-
45
-
-
34848833957
-
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): A randomised trial
-
Facon T, Mary JY, Hulin C, et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial. Lancet. 2007; 370(9594):1209-1218.
-
(2007)
Lancet
, vol.370
, Issue.9594
, pp. 1209-1218
-
-
Facon, T.1
Mary, J.Y.2
Hulin, C.3
-
46
-
-
0032748385
-
Antitumor activity of thalido-mide in refractory multiple myeloma
-
Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalido-mide in refractory multiple myeloma. N Engl J Med. 1999; 341(21): 1565-1571.
-
(1999)
N Engl J Med
, vol.341
, Issue.21
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
47
-
-
0034306974
-
Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
-
Lee CG, Heijn M, di Tomaso E, et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000; 60(19):5565-5570.
-
(2000)
Cancer Res
, vol.60
, Issue.19
, pp. 5565-5570
-
-
Lee, C.G.1
Heijn, M.2
di Tomaso, E.3
-
48
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005; 307(5706):58-62.
-
(2005)
Science
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
49
-
-
77950279550
-
Tumor microvasculature and microenvironment: Novel insights through intravital imaging in pre-clinical models
-
Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010; 17(3):206-225.
-
(2010)
Microcirculation
, vol.17
, Issue.3
, pp. 206-225
-
-
Fukumura, D.1
Duda, D.G.2
Munn, L.L.3
Jain, R.K.4
-
50
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005; 8(4):299-309.
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
51
-
-
47949089077
-
VEGF-targeted therapy: Mechanisms of anti-tumour activity
-
Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008; 8(8):579-591.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.8
, pp. 579-591
-
-
Ellis, L.M.1
Hicklin, D.J.2
-
52
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003; 3(10):721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
53
-
-
0035476509
-
Induction of hypervascu-larity without leakage or inflammation in transgenic mice overex-pressing hypoxia-inducible factor-1alpha
-
Elson DA, Thurston G, Huang LE, et al. Induction of hypervascu-larity without leakage or inflammation in transgenic mice overex-pressing hypoxia-inducible factor-1alpha. Genes Dev. 2001; 15(19): 2520-2532.
-
(2001)
Genes Dev
, vol.15
, Issue.19
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
-
54
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009; 136(5):839-851.
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 839-851
-
-
Mazzone, M.1
Dettori, D.2
de Oliveira, R.L.3
-
55
-
-
0347378566
-
Invasion as limitation to anti-angiogenic glioma therapy
-
Lamszus K, Kunkel P, Westphal M. Invasion as limitation to anti-angiogenic glioma therapy. Acta Neurochir Suppl. 2003; 88:169-177.
-
(2003)
Acta Neurochir Suppl
, vol.88
, pp. 169-177
-
-
Lamszus, K.1
Kunkel, P.2
Westphal, M.3
-
56
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008; 8(8):592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
57
-
-
68049093213
-
Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy
-
Lucio-Eterovic AK, Piao Y, de Groot JF. Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy. Clin Cancer Res. 2009; 15(14):4589-4599.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.14
, pp. 4589-4599
-
-
Lucio-Eterovic, A.K.1
Piao, Y.2
de Groot, J.F.3
-
58
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009; 15(3):220-231.
-
(2009)
Cancer Cell
, vol.15
, Issue.3
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
59
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009; 15(3): 232-239.
-
(2009)
Cancer Cell
, vol.15
, Issue.3
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
60
-
-
41649112610
-
Bevacizumab for recurrent malignant gliomas: Effcacy, toxicity, and patterns of recurrence
-
Norden AD, Young GS, Setayesh K, et al. Bevacizumab for recurrent malignant gliomas: effcacy, toxicity, and patterns of recurrence. Neurolog y. 2008; 70(10):779-787.
-
(2008)
Neurolog Y
, vol.70
, Issue.10
, pp. 779-787
-
-
Norden, A.D.1
Young, G.S.2
Setayesh, K.3
-
61
-
-
74049090120
-
Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme
-
Verhoeff JJ, van Tellingen O, Claes A, et al. Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme. BMC Cancer. 2009; 9:444.
-
(2009)
BMC Cancer
, vol.9
, pp. 444
-
-
Verhoeff, J.J.1
van Tellingen, O.2
Claes, A.3
-
63
-
-
0037490210
-
Hypoxia-inducible factor and its biomedical relevance
-
Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem. 2003; 278(22):19575-19578.
-
(2003)
J Biol Chem
, vol.278
, Issue.22
, pp. 19575-19578
-
-
Huang, L.E.1
Bunn, H.F.2
-
64
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008; 30(4): 393-402.
-
(2008)
Mol Cell
, vol.30
, Issue.4
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
65
-
-
0036359548
-
Hypoxia - a key regulatory factor in tumour growth
-
Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer. 2002; 2(1):38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.1
, pp. 38-47
-
-
Harris, A.L.1
-
66
-
-
33846697957
-
Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression
-
Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression. J Mol Med. 2007; 85(2):139-148.
-
(2007)
J Mol Med
, vol.85
, Issue.2
, pp. 139-148
-
-
Huang, L.E.1
Bindra, R.S.2
Glazer, P.M.3
Harris, A.L.4
-
67
-
-
39749114978
-
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
-
Bristow RG, Hill R P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer. 2008; 8(3):180-192.
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.3
, pp. 180-192
-
-
Bristow, R.G.1
Hill, R.P.2
-
68
-
-
40949108800
-
Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation
-
Huang LE. Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation. Cell Death Differ. 2008(4); 15:672-677.
-
(2008)
Cell Death Differ
, vol.15
, Issue.4
, pp. 672-677
-
-
Huang, L.E.1
-
69
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-defcient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR, et al. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-defcient clear cell renal carcinoma. Cancer Cell. 2008; 14(6):435-446.
-
(2008)
Cancer Cell
, vol.14
, Issue.6
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
-
70
-
-
15244344206
-
HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression
-
Koshiji M, To KK, Hammer S, et al. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. Mol Cell. 2005; 17(6):793-803.
-
(2005)
Mol Cell
, vol.17
, Issue.6
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
-
71
-
-
33750202279
-
The phos-phorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression
-
To KK, Sedelnikova OA, Samons M, Bonner WM, Huang LE. The phos-phorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J. 2006; 25(20):4784-4794.
-
(2006)
EMBO J
, vol.25
, Issue.20
, pp. 4784-4794
-
-
To, K.K.1
Sedelnikova, O.A.2
Samons, M.3
Bonner, W.M.4
Huang, L.E.5
-
72
-
-
3142631736
-
HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. EMBO J. 2004; 23(9):1949-1956.
-
(2004)
EMBO J
, vol.23
, Issue.9
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
73
-
-
79951820679
-
HIF-1α confers aggressive malignant traits on human tumor cells independent of its canonical transcriptional function
-
(In press)
-
Yoo YG, Christensen J, Huang LE. HIF-1α confers aggressive malignant traits on human tumor cells independent of its canonical transcriptional function. Cancer Res. (In press).
-
Cancer Res
-
-
Yoo, Y.G.1
Christensen, J.2
Huang, L.E.3
-
74
-
-
25444432052
-
Genetic instability: The dark side of the hypoxic response
-
To KK, Koshiji M, Hammer S, Huang LE. Genetic instability: the dark side of the hypoxic response. Cell Cycle. 2005; 4(7):881-882.
-
(2005)
Cell Cycle
, vol.4
, Issue.7
, pp. 881-882
-
-
To, K.K.1
Koshiji, M.2
Hammer, S.3
Huang, L.E.4
-
75
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival beneft in a mouse model of cancer
-
Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose 'chemo-switch' regimen is antiangiogenic, producing objective responses and survival beneft in a mouse model of cancer. J Clin Oncol. 2005; 23(5):939-952.
-
(2005)
J Clin Oncol
, vol.23
, Issue.5
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
76
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
Melillo G. Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res. 2006; 4(9):601-605.
-
(2006)
Mol Cancer Res
, vol.4
, Issue.9
, pp. 601-605
-
-
Melillo, G.1
-
77
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker RH, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004; 64(4):1475-1482.
-
(2004)
Cancer Res
, vol.64
, Issue.4
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
Pommier, Y.4
Shoemaker, R.H.5
Melillo, G.6
-
78
-
-
67651166780
-
Increased antitu-mor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
-
Rapisarda A, Hollingshead M, Uranchimeg B, et al. Increased antitu-mor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther. 2009; 8(7):1867-1877.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.7
, pp. 1867-1877
-
-
Rapisarda, A.1
Hollingshead, M.2
Uranchimeg, B.3
|