Depressive-like profile induced by MCH microinjections into the dorsal raphe nucleus evaluated in the forced swim test

Behavioural Brain Research

Volumn 218, Issue 2, 2011, Pages 259-266

  Lagos, Patricia ^a   Urbanavicius, Jessika ^a,b   Scorza, María Cecilia ^a,b   Miraballes, Rodrigo ^b   Torterolo, Pablo ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

Author keywords

Depression; Hypothalamus; Mood disorders; Neuropeptide; Open field test

Indexed keywords

FLUOXETINE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; PROTEIN ANTIBODY;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLIMBING; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; FORCED SWIMMING TEST; GROOMING; HYPOTHALAMUS; IMMOBILIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR DEPRESSION; MALE; MOOD DISORDER; MOTOR ACTIVITY; NONHUMAN; OPEN FIELD TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REARING; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM;

EID: 79151486668     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2010.10.035     Document Type: Article

References (85)

1. Fava M., Kendler K.S. Major depressive disorder. Neuron 2000, 28:335-341.
2. Boyd J.H., Weissman M.M. Epidemiology of affective disorders. A reexamination and future directions. Arch Gen Psychiatry 1981, 38:1039-1046.
3. Murray C.J., Lopez A.D. The global burden of disease 1996, World Health Organization, Geneva.
4. Murray C.J., Lopez A.D. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997, 349:1498-1504.
5. Murray C.J., Lopez A.D. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997, 349:1436-1442.
6. Benca R.M. Mood disorders. Principles and practices of sleep medicine 2005, 1311-1326. Elsevier-Saunders, Philadelphia. M.H. Kryger (Ed.).
7. Van Praag H.M. The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders. Biol Psychiatry 1977, 12:101-131.
8. van Praag H.M., de Haan S. Central serotonin metabolism and frequency of depression. Psychiatry Res 1979, 1:219-224.
9. Young S.N. The use of diet and dietary components in the study of factors controlling affect in humans: a review. J Psychiatry Neurosci 1993, 18:235-244.
10. Roy A., De Jong J., Linnoila M. Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. A 5-year follow-up study. Arch Gen Psychiatry 1989, 46:609-612.
11. Traskman-Bendz L., Alling C., Oreland L., Regnell G., Vinge E., Ohman R. Prediction of suicidal behavior from biologic tests. J Clin Psychopharmacol 1992, 12:21S-26S.
12. Nordstrom P., Samuelsson M., Asberg M., Traskman-Bendz L., Aberg-Wistedt A., Nordin C., et al. CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life Threat Behav 1994, 24:1-9.
13. Mann J.J., Brent D.A., Arango V. The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 2001, 24:467-477.
14. Kalia M. Neurobiological basis of depression: an update. Metabolism 2005, 54:24-27.
15. Berton O., Nestler E.J. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006, 7:137-151.
16. Arango V., Underwood M.D., Gubbi A.V., Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 1995, 688:121-133.
17. Mann J.J. The neurobiology of suicide. Nat Med 1998, 4:25-30.
18. Courtet P., Jollant F., Castelnau D., Buresi C., Malafosse A. Suicidal behavior: relationship between phenotype and serotonergic genotype. Am J Med Genet C Semin Med Genet 2005, 133:25-33.
19. Hamet P., Tremblay J. Genetics and genomics of depression. Metabolism 2005, 54:10-15.
20. Bondy B., Buettner A., Zill P. Genetics of suicide. Mol Psychiatry 2006, 11:336-351.
21. Keller M.B., Lavori P.W., Mueller T.I., Endicott J., Coryell W., Hirschfeld R.M., et al. Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. Arch Gen Psychiatry 1992, 49:809-816.
22. Holtzheimer P.E., Nemeroff C.B. Advances in the treatment of depression. NeuroRx 2006, 3:42-56.
23. Underwood M.D., Khaibulina A.A., Ellis S.P., Moran A., Rice P.M., Mann J.J., et al. Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol Psychiatry 1999, 46:473-483.
24. Arango V., Underwood M.D., Boldrini M., Tamir H., Kassir S.A., Hsiung S., et al. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 2001, 25:892-903.
25. Arango V., Underwood M.D., Mann J.J. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002, 136:443-453.
26. Boldrini M., Underwood M.D., Mann J.J., Arango V. More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 2005, 1041:19-28.
27. Bach-Mizrachi H., Underwood M.D., Kassir S.A., Bakalian M.J., Sibille E., Tamir H., et al. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 2006, 31:814-824.
28. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., et al. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992, 319:218-245.
29. Mouri T., Takahashi K., Kawauchi H., Sone M., Totsune K., Murakami O., et al. Melanin-concentrating hormone in the human brain. Peptides 1993, 14:643-646.
30. Torterolo P., Sampogna S., Morales F.R., Chase M.H. MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness. Brain Res 2006, 1119:101-114.
31. Bittencourt J., Celis M.E. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides 2008, 29:1441-1450.
32. Nahon J.L. The melanocortins and melanin-concentrating hormone in the central regulation of feeding behavior and energy homeostasis. C R Biol 2006, 329:623-638. discussion 653-625.
33. Saito Y., Nagasaki H. The melanin-concentrating hormone system and its physiological functions. Results Probl Cell Differ 2008, 46:159-179.
34. Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A.W., Hreniuk D.L., et al. Melanin-concentrating hormone receptor subtypes 1 and 2: species- specific gene expression. Genomics 2002, 79:785-792.
35. Hervieu G.J., Cluderay J.E., Harrison D., Meakin J., Maycox P., Nasir S., et al. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur J Neurosci 2000, 12:1194-1216.
36. Saito Y., Cheng M., Leslie F.M., Civelli O. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol 2001, 435:26-40.
37. Torterolo P., Lagos P., Sampogna S., Chase M.H. Melanin-concentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the cat. Brain Res 2008, 1210:163-178.
38. Torterolo P., Sampogna S., Chase M.H. MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep. Brain Res 2009, 1268:76-87.
39. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., DeLeon J., Heurich R., et al. Antidepressant, anxiolytic and anorectic effects of a melanin- concentrating hormone-1 receptor antagonist. Nat Med 2002, 8:825-830.
40. Basso A.M., Bratcher N.A., Gallagher K.B., Cowart M.D., Zhao C., Sun M., et al. Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. Eur J Pharmacol 2006, 540:115-120.
41. Chaki S., Funakoshi T., Hirota-Okuno S., Nishiguchi M., Shimazaki T., Iijima M., et al. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther 2005, 313:831-839.
42. David D.J., Klemenhagen K.C., Holick K.A., Saxe M.D., Mendez I., Santarelli L., et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther 2007, 321:237-248.
43. Millan M.J., Gobert A., Panayi F., Rivet J.M., Dekeyne A., Brocco M., et al. The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats. Int J Neuropsychopharmacol 2008, 11:1105-1122.
44. Gehlert D.R., Rasmussen K., Shaw J., Li X., Ardayfio P., Craft L., et al. Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression. J Pharmacol Exp Ther 2009, 329:429-438.
45. McGregor R., Damian A., Fabbiani G., Torterolo P., Pose I., Chase M., et al. Direct hypothalamic innervation of the trigeminal motor nucleus: a retrograde tracer study. Neuroscience 2005, 136:1073-1081.
46. Paxinos G., Watson C. The rat brain 2005, Academic Press, New York.
47. Verret L., Goutagny R., Fort P., Cagnon L., Salvert D., Leger L., et al. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 2003, 4:19.
48. Modirrousta M., Mainville L., Jones B.E. Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci 2005, 21:2807-2816.
49. Detke M.J., Rickels M., Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 1995, 121:66-72.
50. Detke M.J., Lucki I. Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth. Behav Brain Res 1996, 73:43-46.
51. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
52. Porsolt R.D., Anton G., Blavet N., Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978, 47:379-391.
53. Porsolt R.D., Brossard G., Hautbois C., Roux S. Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci 2001, [chapter 8, unit 8 10A].
54. Cryan J.F., Lucki I. Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine (2C) receptors. J Pharmacol Exp Ther 2000, 295:1120-1126.
55. Cryan J.F., Valentino R.J., Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 2005, 29:547-569.
56. Slattery D.A., Desrayaud S., Cryan J.F. GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent. J Pharmacol Exp Ther 2005, 312:290-296.
57. Lagos P., Scorza C., Monti J.M., Jantos H., Reyes-Parada M., Silveira R., et al. Effects of the D3 preferring dopamine agonist pramipexole on sleep and waking, locomotor activity and striatal dopamine release in rats. Eur Neuropsychopharmacol 1998, 8:113-120.
58. Scorza M.C., Meikle M.N., Hill X.L., Richeri A., Lorenzo D., Artigas F. Prefrontal cortex lesions cause only minor effects on the hyperlocomotion induced by MK-801 and its reversal by clozapine. Int J Neuropsychopharmacol 2008, 11:519-532.
59. Lagos P., Torterolo P., Jantos H., Chase M.H., Monti J.M. Effects on sleep of melanin-concentrating hormone microinjections into the dorsal raphe nucleus. Brain Res 2009, 1265:103-110.
60. Georgescu D., Sears R.M., Hommel J.D., Barrot M., Bolanos C.A., Marsh D.J., et al. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci 2005, 25:2933-2940.
61. Stanley B.G., Magdalin W., Seirafi A., Nguyen M.M., Leibowitz S.F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides 1992, 13:581-587.
62. Lambert P.D., Wilding J.P., al-Dokhayel A.A., Bohuon C., Comoy E., Gilbey S.G., et al. A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. Endocrinology 1993, 133:29-32.
63. Roky R., Valatx J.L., Paut-Pagano L., Jouvet M. Hypothalamic injection of prolactin or its antibody alters the rat sleep-wake cycle. Physiol Behav 1994, 55:1015-1019.
64. Yamada H., Okumura T., Motomura W., Kobayashi Y., Kohgo Y. Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochem Biophys Res Commun 2000, 267:527-531.
65. Matsuda K., Shimakura S., Miura T., Maruyama K., Uchiyama M., Kawauchi H., et al. Feeding-induced changes of melanin-concentrating hormone (MCH)-like immunoreactivity in goldfish brain. Cell Tissue Res 2007, 328:375-382.
66. Zupanc G.K. Peptidergic transmission: from morphological correlates to functional implications. Micron 1996, 27:35-91.
67. Rivera G., Bocanegra-Garcia V., Galiano S., Cirauqui N., Ceras J., Perez S., et al. Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr Med Chem 2008, 15:1025-1043.
68. Kuteeva E., Wardi T., Lundstrom L., Sollenberg U., Langel U., Hokfelt T., et al. Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level. Neuropsychopharmacology 2008, 33:2573-2585.
69. Roy M., David N., Cueva M., Giorgetti M. A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression. Biol Psychiatry 2006, 31:112-120.
70. Cryan J.F., Markou A., Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 2002, 23:238-245.
71. Cryan J.F., Page M.E., Lucki I. Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur J Pharmacol 2002, 436:197-205.
72. Gobert A., Millan M.J. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology 1999, 21:268-284.
73. Reneric J.P., Bouvard M., Stinus L. Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test. Neuropsychopharmacology 2001, 24:379-390.
74. Adell A., Celada P., Abellan M.T., Artigas F. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res Brain Res Rev 2002, 39:154-180.
75. Roy M., David N., Cueva M., Giorgetti M. A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression. Biol Psychiatry 2007, 61:174-180.
76. Kilduff T.S., De Lecea L. Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. J Comp Neurol 2001, 435:1-5.
77. Forray C. The MCH receptor family: feeding brain disorders?. Curr Opin Pharmacol 2003, 3:85-89.
78. Shi Y. Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions. Peptides 2004, 25:1605-1611.
79. Gao X.B., van den Pol A.N. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol 2001, 533:237-252.
80. Qu D., Ludwig D.S., Gammeltoft S., Piper M., Pelleymounter M.A., Cullen M.J., et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996, 380:243-247.
81. Peyron C., Sapin E., Leger L., Luppi P.H., Fort P. Role of the melanin-concentrating hormone neuropeptide in sleep regulation. Peptides 2009, 30:2052-2059.
82. Adrien J. Neurobiological bases for the relation between sleep and depression. Sleep Med Rev 2002, 6:341-351.
83. Yavari P., Vogel G.W., Neill D.B. Decreased raphe unit activity in a rat model of endogenous depression. Brain Res 1993, 611:31-36.
84. Gardner J.P., Fornal C.A., Jacobs B.L. Effects of sleep deprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat. Neuropsychopharmacology 1997, 17:72-81.
85. Temel Y., Boothman L.J., Blokland A., Magill P.J., Steinbusch H.W., Visser-Vandewalle V., et al. Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus. Proc Natl Acad Sci USA 2007, 104:17087-17092.