Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety

European Journal of Pharmacology

Volumn 540, Issue 1-3, 2006, Pages 115-120

  Basso, Ana M ^a   Bratcher, Natalie A ^a   Gallagher, Kelly B ^a   Cowart, Marlon D ^a   Zhao, Chen ^a   Sun, Minghua ^a   Esbenshade, Timothy A ^a   Brune, Michael E ^a   Fox, Gerard B ^a   Schmidt, Martin ^a   Collins, Christine A ^a   Souers, Andrew J ^a   Iyengar, Rajesh ^a   Vasudevan, Anil ^a   Kym, Philip R ^a   Hancock, Arthur A ^a   Rueter, Lynne E ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

(Mouse); (Rat); Anxiety; Depression; MCH 1 receptor antagonists

Indexed keywords

A 665798; A 777903; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE 1 RECEPTOR ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; SNAP 7941; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG BIOAVAILABILITY; DRUG PENETRATION; MALE; MOOD DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; TASK PERFORMANCE; VALIDATION PROCESS;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BENZOPYRANS; BIPHENYL COMPOUNDS; CONFLICT (PSYCHOLOGY); DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; HINDLIMB SUSPENSION; INDAZOLES; MALE; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NAPHTHALENES; PIPERIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, SOMATOSTATIN; SWIMMING;

EID: 33744995503     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.04.043     Document Type: Article

References (17)

1. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., DeLeon J., Lagu B., Heurich R., Lichtblau H., Shaposhnik Z., Daniewska I., Blackburn T.P., Branchek T.A., Gerald C., Vaysse P.J., and Forray C. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 8 (2002) 825-830
2. Chaki S., Funakoshi T., Hirota-Okuno S., Nishiguchi M., Shimazaki T., Iijima M., Grottick A.J., Kanuma K., Omodera K., Sekiguchi Y., Okuyama S., Tran T.A., Semple G., and Thomsen W. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J. Pharmacol. Exp. Ther. 313 (2005) 831-839
3. Detke M.J., Rickels M., and Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121 (1995) 66-72
4. Georgescu D., Sears R.M., Hommel J.D., Barrot M., Bolanos C.A., Marsh D.J., Bednarek M.A., Bibb J.A., Maratos-Flier E., Nestler E.J., and DiLeone R.J. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J. Neurosci. 25 (2005) 2933-2940
5. Gonzalez M.I., Vaziri S., and Wilson C.A. Behavioral effects of alpha-MSH and MCH after central administration in the female rat. Peptides 17 (1996) 171-177
6. Hervieu G. Melanin-concentrating hormone functions in the nervous system: food intake and stress. Expert Opin. Ther. Targets 7 (2003) 495-511
7. Kela J., Salmi P., Rimondini-Giorgini R., Heilig M., and Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regul. Pept. 114 (2003) 109-114
8. Kennedy A.R., Todd J.F., Dhillo W.S., Seal L.J., Ghatei M.A., O'Toole C.P., Jones M., Witty D., Winborne K., Riley G., Hervieu G., Wilson S., and Bloom S.R. Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1. J. Neuroendocrinol. 15 (2003) 268-272
9. Kym P.R., Iyengar R., Souers A.J., Lynch J.K., Judd A.S., Gao J., Freeman J., Mulhern M., Zhao G., Vasudevan A., Wodka D., Blackburn C., Brown J., Che J.L., Cullis C., Lai S.J., LaMarche M.J., Marsilje T., Roses J., Sells T., Geddes B., Govek E., Patane M., Fry D., Dayton B.D., Brodjian S., Falls D., Brune M., Bush E., Shapiro R., Knourek-Segel V., Fey T., McDowell C., Reinhart G.A., Preusser L.C., Marsh K., Hernandez L., Sham H.L., and Collins C.A. Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists. J. Med. Chem. 48 (2005) 5888-5891
10. Ludwig D.S., Mountjoy K.G., Tatro J.B., Gillette J.A., Frederich R.C., Flier J.S., and Maratos-Flier E. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am. J. Physiol. 274 (1998) E627-E633
11. Mancinelli A., Borsini F., d'Aranno V., Lecci A., and Meli A. Cholinergic drug effects on antidepressant-induced behaviour in the forced swimming test. Eur. J. Pharmacol. 158 (1988) 199-205
12. Marsh D.J., Weingarth D.T., Novi D.E., Chen H.Y., Trumbauer M.E., Chen A.S., Guan X.M., Jiang M.M., Feng Y., Camacho R.E., Shen Z., Frazier E.G., Yu H., Metzger J.M., Kuca S.J., Shearman L.P., Gopal-Truter S., MacNeil D.J., Strack A.M., MacIntyre D.E., Van der Ploeg L.H., and Qian S. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 3240-3245
13. Monzon M.E., and De Barioglio S.R. Response to novelty after i.c.v. injection of melanin-concentrating hormone (MCH) in rats. Physiol. Behav. 67 (1999) 813-817
14. Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 (1978) 379-391
15. Saito Y., Nothacker H.P., Wang Z., Lin S.H., Leslie F., and Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400 (1999) 265-269
16. Takekawa S., Asami A., Ishihara Y., Terauchi J., Kato K., Shimomura Y., Mori M., Murakoshi H., Suzuki N., Nishimura O., and Fujino M. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur. J. Pharmacol. 438 (2002) 129-135
17. Vasudevan A., Souers A.J., Freeman J.C., Verzal M.K., Gao J., Mulhern M.M., Wodka D., Lynch J.K., Engstrom K.M., Wagaw S.H., Brodjian S., Dayton B., Falls D.H., Bush E., Brune M., Shapiro R.D., Marsh K.C., Hernandez L.E., Collins C.A., and Kym P.R. Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists. Bioorg. Med. Chem. Lett. 15 (2005) 5293-5297