메뉴 건너뛰기




Volumn 82, Issue 1, 2011, Pages 71-79

The classical drug discovery approach to defining bioactive constituents of botanicals

Author keywords

A ai (Euterpe oleracea); Baobab (Adansonia digitata); Biologically active constituents; Licorice (Glycyrrhiza glabra); Mangosteen (Garcinia mangostana); Noni (Morinda citrifolia)

Indexed keywords

1,2 DIHYDROPARATOCARPIN; 5 METHOXY DIHYDRODEHYDROCONIFERYL; 5 METHOXYISOLARICIRESINOL; 8 HYDROXYCUDRAXANTHONE G; ADANSONIA DIGITATA EXTRACT; ALPHA MANGOSTIN; ANTIOXIDANT; CHALCONE DERIVATIVE; EPICATECHIN; EUTERPE OLERACEA EXTRACT; GAMMA MANGOSTIN; GARCINIA MANGOSTANA EXTRACT; GARTANIN; GLYCYRRHIZA GLABRA EXTRACT; HISPAGLABDRIDIN B; ISOLIQUIRITIGENIN; LIGNAN DERIVATIVE; MORINDA CITRIFOLIA EXTRACT; NEOLIGNAN LIPID ESTER; PARATOCARPIN B; PLANT EXTRACT; PROCYANIDIN; PROCYANIDIN B2; PROCYANIDIN B5; PROCYANIDIN DERIVATIVE; SECOISOLARICIRESINOL; SMEATHXANTHONE A; SYRINGARESINOL; THREO 1 (4 HYDROXY 3 METHOXYPHENYL) 2 [4 (3 HYDROXYPROPYL) 2 METHOCYPHENOXYL] 1,3 PROPANEDIOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79151482956     PISSN: 0367326X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fitote.2010.08.015     Document Type: Review
Times cited : (41)

References (58)
  • 1
    • 0036318997 scopus 로고    scopus 로고
    • Challenges and opportunities confronting the botanical dietary supplement industry
    • J.H. Cardellina II Challenges and opportunities confronting the botanical dietary supplement industry J Nat Prod 65 2002 1073 1084
    • (2002) J Nat Prod , vol.65 , pp. 1073-1084
    • Cardellina, J.H.I.I.1
  • 2
    • 77952983897 scopus 로고    scopus 로고
    • Lessons learned from herbal medicinal products: The example of St. John's Wort
    • A. Nahrstedt, and V. Butterweck Lessons learned from herbal medicinal products: the example of St. John's Wort J Nat Prod 73 2010 1015 1021
    • (2010) J Nat Prod , vol.73 , pp. 1015-1021
    • Nahrstedt, A.1    Butterweck, V.2
  • 3
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Y.-J. Surh Cancer chemoprevention with dietary phytochemicals Nat Rev Cancer 3 2003 768 780
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.-J.1
  • 4
    • 77953205368 scopus 로고    scopus 로고
    • Cancer chemoprevention by natural products: How far have we come?
    • R.G. Mehta, G. Murillo, R. Naithani, and X. Peng Cancer chemoprevention by natural products: how far have we come? Pharm Res 27 2010 950 961
    • (2010) Pharm Res , vol.27 , pp. 950-961
    • Mehta, R.G.1    Murillo, G.2    Naithani, R.3    Peng, X.4
  • 6
    • 58149382835 scopus 로고    scopus 로고
    • Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: A comprehensive review
    • R.G. Mehta, R. Naithani, L. Huma, M. Hawthorne, R.M. Moriarty, and D.L. McCormick Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive review Curr Med Chem 15 2008 2785 2825
    • (2008) Curr Med Chem , vol.15 , pp. 2785-2825
    • Mehta, R.G.1    Naithani, R.2    Huma, L.3    Hawthorne, M.4    Moriarty, R.M.5    McCormick, D.L.6
  • 7
    • 79151482173 scopus 로고    scopus 로고
    • Accessed June 16, 2010
    • http://clinicaltrials.gov. (Accessed June 16, 2010)
  • 8
    • 0030608256 scopus 로고    scopus 로고
    • The economic value of managing the açaí palm (Euterpe oleracea Mart.) in the floodplains of the Amazon estuary, Pará, Brazil
    • N. Muñez-Miret, R. Vamos, M. Haraoka, F. Montingnini, and R.O. Mendelsohn The economic value of managing the açaí palm (Euterpe oleracea Mart.) in the floodplains of the Amazon estuary, Pará, Brazil For Ecol Manage 87 1996 163 173
    • (1996) For Ecol Manage , vol.87 , pp. 163-173
    • Muñez-Miret, N.1    Vamos, R.2    Haraoka, M.3    Montingnini, F.4    Mendelsohn, R.O.5
  • 10
    • 34147136094 scopus 로고    scopus 로고
    • Amazonian berry
    • A. Jagger Amazonian berry Chem Ind 6 2007 24 25
    • (2007) Chem Ind , Issue.6 , pp. 24-25
    • Jagger, A.1
  • 12
    • 1642317046 scopus 로고    scopus 로고
    • Phytochemical composition and pigment stability of açaí (Euterpe oleracea Mart.)
    • D. Del Pozo-Insfran, C.H. Brenes, and S.T. Talcott Phytochemical composition and pigment stability of açaí (Euterpe oleracea Mart.) J Agric Food Chem 52 2004 1539 1545
    • (2004) J Agric Food Chem , vol.52 , pp. 1539-1545
    • Del Pozo-Insfran, D.1    Brenes, C.H.2    Talcott, S.T.3
  • 14
    • 33745758113 scopus 로고    scopus 로고
    • Total oxidant scavenging capacity of Euterpe oleracea Mart. (açai) seeds and identification of their polyphenolic compounds
    • R.B. Rodrigues, R. Lichtenthäler, B.F. Zimmermann, M. Papagiannopoulos, H. Fabricius, and F. Marx Total oxidant scavenging capacity of Euterpe oleracea Mart. (açai) seeds and identification of their polyphenolic compounds J Agric Food Chem 54 2006 4162 4167
    • (2006) J Agric Food Chem , vol.54 , pp. 4162-4167
    • Rodrigues, R.B.1    Lichtenthäler, R.2    Zimmermann, B.F.3    Papagiannopoulos, M.4    Fabricius, H.5    Marx, F.6
  • 16
    • 77951650036 scopus 로고    scopus 로고
    • Anti-oxidant capacities of flavonoid compounds isolated from açai pulp (Euterpe oleracea Mart.)
    • J. Kang, Z. Li, T. Wu, G.S. Jensen, A.G. Schauss, and X. Wu Anti-oxidant capacities of flavonoid compounds isolated from açai pulp (Euterpe oleracea Mart.) Food Chem 122 2010 610 617
    • (2010) Food Chem , vol.122 , pp. 610-617
    • Kang, J.1    Li, Z.2    Wu, T.3    Jensen, G.S.4    Schauss, A.G.5    Wu, X.6
  • 17
    • 52649120818 scopus 로고    scopus 로고
    • Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers
    • S.U. Mertens-Talcott, J. Rios, P. Jilma-Stohlawetz, L.A. Pacheco-Palencia, B. Meibohm, and S.T. Talcott Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers J Agric Food Chem 56 2008 7796 7802
    • (2008) J Agric Food Chem , vol.56 , pp. 7796-7802
    • Mertens-Talcott, S.U.1    Rios, J.2    Jilma-Stohlawetz, P.3    Pacheco-Palencia, L.A.4    Meibohm, B.5    Talcott, S.T.6
  • 18
    • 52649091798 scopus 로고    scopus 로고
    • Lignans and other constituents of the fruits of Euterpe oleracea (Açaí) with antioxidant and cytoprotective activities
    • Y.-W. Chin, H.-B. Chai, W.J. Keller, and A.D. Kinghorn Lignans and other constituents of the fruits of Euterpe oleracea (Açaí) with antioxidant and cytoprotective activities J Agric Food Chem 56 2008 7759 7764
    • (2008) J Agric Food Chem , vol.56 , pp. 7759-7764
    • Chin, Y.-W.1    Chai, H.-B.2    Keller, W.J.3    Kinghorn, A.D.4
  • 19
    • 0036629613 scopus 로고    scopus 로고
    • Baobab (Adansonia digitata L.); A review on a multipurpose tree with promising future in Sudan
    • J. Gebauer, K. El-Siddig, and G. Ebert Baobab (Adansonia digitata L.); a review on a multipurpose tree with promising future in Sudan Gartenbauwissenschaft 67 2002 155 160
    • (2002) Gartenbauwissenschaft , vol.67 , pp. 155-160
    • Gebauer, J.1    El-Siddig, K.2    Ebert, G.3
  • 21
    • 0028130649 scopus 로고
    • Anti-inflammatory, analgesic and antipyretic effects of the fruit pulp of Adansonia digitata
    • A. Ramadan, F.M. Harraz, and S.A. El-Mougy Anti-inflammatory, analgesic and antipyretic effects of the fruit pulp of Adansonia digitata Fitoterapia 65 1994 418 422
    • (1994) Fitoterapia , vol.65 , pp. 418-422
    • Ramadan, A.1    Harraz, F.M.2    El-Mougy, S.A.3
  • 22
    • 33747615286 scopus 로고    scopus 로고
    • Procyanidins from Adansonia digitata
    • A.A. Shahat Procyanidins from Adansonia digitata Pharm Biol 44 2006 445 450
    • (2006) Pharm Biol , vol.44 , pp. 445-450
    • Shahat, A.A.1
  • 25
    • 0025050487 scopus 로고
    • Liquorice, Glycyrrhiza glabra L.-composition, uses and analysis
    • G.R. Fenwick, J. Lutomski, and C. Nieman Liquorice, Glycyrrhiza glabra L.-composition, uses and analysis Food Chem 38 1990 119 143
    • (1990) Food Chem , vol.38 , pp. 119-143
    • Fenwick, G.R.1    Lutomski, J.2    Nieman, C.3
  • 26
    • 0036664733 scopus 로고    scopus 로고
    • Licorice root. A natural sweetener and an important ingredient in Chinese medicines
    • I. Kitagawa Licorice root. A natural sweetener and an important ingredient in Chinese medicines Pure Appl Chem 34 2002 1189 1198
    • (2002) Pure Appl Chem , vol.34 , pp. 1189-1198
    • Kitagawa, I.1
  • 27
    • 0036664506 scopus 로고    scopus 로고
    • Chemistry of phenolic compounds of licorice (Glycyrrhiza) species) and their estrogenic and cytotoxic activities
    • T. Nomura, T. Fukai, and T. Akiyama Chemistry of phenolic compounds of licorice (Glycyrrhiza) species) and their estrogenic and cytotoxic activities Pure Appl Chem 34 2002 1199 1206
    • (2002) Pure Appl Chem , vol.34 , pp. 1199-1206
    • Nomura, T.1    Fukai, T.2    Akiyama, T.3
  • 28
  • 29
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    • M.N. Asl, and H. Hosseinzadeh Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds Phytother Res 22 2008 709 724
    • (2008) Phytother Res , vol.22 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 30
    • 34250692468 scopus 로고    scopus 로고
    • Antioxidant constituents of the roots and stolons of Licorice (Glycyrrhiza glabra)
    • Y.-W. Chin, H.-A. Jung, B.-N. Su, Y. Liu, J.A. Castoro, and W.J. Keller Antioxidant constituents of the roots and stolons of Licorice (Glycyrrhiza glabra) J Agric Food Chem 55 2007 4691 4697
    • (2007) J Agric Food Chem , vol.55 , pp. 4691-4697
    • Chin, Y.-W.1    Jung, H.-A.2    Su, B.-N.3    Liu, Y.4    Castoro, J.A.5    Keller, W.J.6
  • 32
    • 0015146835 scopus 로고
    • Isolation of two new flavonoids from the root of Glycyrrhiza glabra var. typica
    • C. van Hulle, P. Braeckman, and M. Vandewalle Isolation of two new flavonoids from the root of Glycyrrhiza glabra var. typica Planta Med 20 1971 278 282
    • (1971) Planta Med , vol.20 , pp. 278-282
    • Van Hulle, C.1    Braeckman, P.2    Vandewalle, M.3
  • 33
    • 14644438586 scopus 로고    scopus 로고
    • Chemoprevention: Mouse colon and lung bioassay and modulation of DNA methylation as a biomarker
    • M.A. Periera, L.H. Tao, W. Wang, W.T. Gunning, and R.A. Lubet Chemoprevention: mouse colon and lung bioassay and modulation of DNA methylation as a biomarker Exp Lung Res 31 2005 145 163
    • (2005) Exp Lung Res , vol.31 , pp. 145-163
    • Periera, M.A.1    Tao, L.H.2    Wang, W.3    Gunning, W.T.4    Lubet, R.A.5
  • 34
    • 57249112596 scopus 로고    scopus 로고
    • Structural characterization, biological effects, and synthetic studies on xanthones from the fruits of mangosteen (Garcinia mangostana), a popular botanical dietary supplement
    • Y.-W. Chin, and A.D. Kinghorn Structural characterization, biological effects, and synthetic studies on xanthones from the fruits of mangosteen (Garcinia mangostana), a popular botanical dietary supplement Mini-Rev Org Chem 5 2008 355 364
    • (2008) Mini-Rev Org Chem , vol.5 , pp. 355-364
    • Chin, Y.-W.1    Kinghorn, A.D.2
  • 35
  • 37
    • 33645765822 scopus 로고    scopus 로고
    • Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen)
    • H.-A. Jung, B.-N. Su, W.J. Keller, R.G. Mehta, and A.D. Kinghorn Antioxidant xanthones from the pericarp of Garcinia mangostana (mangosteen) J Agric Food Chem 54 2008 2077 2082
    • (2008) J Agric Food Chem , vol.54 , pp. 2077-2082
    • Jung, H.-A.1    Su, B.-N.2    Keller, W.J.3    Mehta, R.G.4    Kinghorn, A.D.5
  • 38
    • 38349174516 scopus 로고    scopus 로고
    • Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (mangosteen)
    • Y.-W. Chin, H.A. Jung, H. Chai, W.J. Keller, and A.D. Kinghorn Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (mangosteen) Phytochemistry 69 2008 754 758
    • (2008) Phytochemistry , vol.69 , pp. 754-758
    • Chin, Y.-W.1    Jung, H.A.2    Chai, H.3    Keller, W.J.4    Kinghorn, A.D.5
  • 39
    • 70349918140 scopus 로고    scopus 로고
    • Bioavailability and antioxidant effects of a xanthone-rich mangosteen (Garcinia mangostana) product in humans
    • M. Kondo, L. Zhang, H. Ji, Y. Kou, and B. Ou Bioavailability and antioxidant effects of a xanthone-rich mangosteen (Garcinia mangostana) product in humans J Agric Food Chem 57 2009 8788 8792
    • (2009) J Agric Food Chem , vol.57 , pp. 8788-8792
    • Kondo, M.1    Zhang, L.2    Ji, H.3    Kou, Y.4    Ou, B.5
  • 41
    • 49049113260 scopus 로고    scopus 로고
    • Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity
    • M.J. Balunas, B. Su, R.W. Brueggemeier, and A.D. Kinghorn Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity J Nat Prod 71 2008 1161 1166
    • (2008) J Nat Prod , vol.71 , pp. 1161-1166
    • Balunas, M.J.1    Su, B.2    Brueggemeier, R.W.3    Kinghorn, A.D.4
  • 42
    • 16644370363 scopus 로고    scopus 로고
    • Inhibitory effects of crude α-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat
    • V. Nabandith, M. Suzui, T. Morioka, T. Kaneshiro, T. Kinjo, and K. Matsumoto Inhibitory effects of crude α-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat Asian Pac J Cancer Prev 5 2004 433 438
    • (2004) Asian Pac J Cancer Prev , vol.5 , pp. 433-438
    • Nabandith, V.1    Suzui, M.2    Morioka, T.3    Kaneshiro, T.4    Kinjo, T.5    Matsumoto, K.6
  • 43
    • 36849033330 scopus 로고    scopus 로고
    • Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni)
    • A.D. Pawlus, and A.D. Kinghorn Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni) J Pharm Pharmacol 59 2007 1587 1609
    • (2007) J Pharm Pharmacol , vol.59 , pp. 1587-1609
    • Pawlus, A.D.1    Kinghorn, A.D.2
  • 44
    • 34250374867 scopus 로고    scopus 로고
    • Morinda citrifolia (noni) fruit: Phytochemistry, pharmacology, safety
    • O. Potterat, and M. Hamburger Morinda citrifolia (noni) fruit: phytochemistry, pharmacology, safety Planta Med 73 2007 191 199
    • (2007) Planta Med , vol.73 , pp. 191-199
    • Potterat, O.1    Hamburger, M.2
  • 46
    • 17844393868 scopus 로고    scopus 로고
    • Chemical constituents of the fruits of Morinda citrifolia (noni) and their antioxidant activity
    • B.-N. Su, A.D. Pawlus, H.-A. Jung, W.J. Keller, J.L. McLaughlin, and A.D. Kinghorn Chemical constituents of the fruits of Morinda citrifolia (noni) and their antioxidant activity J Nat Prod 68 2005 592 595
    • (2005) J Nat Prod , vol.68 , pp. 592-595
    • Su, B.-N.1    Pawlus, A.D.2    Jung, H.-A.3    Keller, W.J.4    McLaughlin, J.L.5    Kinghorn, A.D.6
  • 47
    • 51849183617 scopus 로고
    • Antiinflammatory activity of americanin A
    • E.B. Lee, Y.S. Lee, and W.S. Woo Antiinflammatory activity of americanin A Arch Pharm Res 8 1985 139 147
    • (1985) Arch Pharm Res , vol.8 , pp. 139-147
    • Lee, E.B.1    Lee, Y.S.2    Woo, W.S.3
  • 48
    • 30544455292 scopus 로고    scopus 로고
    • An anthraquinone with potent quinone reductase-inducing activity and other constituents from the fruits of Morinda citrifolia (noni)
    • A.D. Pawlus, B.-N. Su, W.J. Keller, and A.D. Kinghorn An anthraquinone with potent quinone reductase-inducing activity and other constituents from the fruits of Morinda citrifolia (noni) J Nat Prod 68 2005 1720 1722
    • (2005) J Nat Prod , vol.68 , pp. 1720-1722
    • Pawlus, A.D.1    Su, B.-N.2    Keller, W.J.3    Kinghorn, A.D.4
  • 49
    • 38348999195 scopus 로고    scopus 로고
    • Anthaquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots
    • Y. Deng, Y.-W. Chin, H. Chai, W.J. Keller, and A.D. Kinghorn Anthaquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots J Nat Prod 70 2007 2049 2052
    • (2007) J Nat Prod , vol.70 , pp. 2049-2052
    • Deng, Y.1    Chin, Y.-W.2    Chai, H.3    Keller, W.J.4    Kinghorn, A.D.5
  • 50
    • 28544434709 scopus 로고    scopus 로고
    • New anthraquinone and iridoid from the fruits of Morinda citrifolia
    • K. Kamiya, Y. Tanaka, H. Endang, M. Umar, and T. Sakate New anthraquinone and iridoid from the fruits of Morinda citrifolia Chem Pharm Bull 53 2005 1597 1599
    • (2005) Chem Pharm Bull , vol.53 , pp. 1597-1599
    • Kamiya, K.1    Tanaka, Y.2    Endang, H.3    Umar, M.4    Sakate, T.5
  • 51
    • 34250790243 scopus 로고    scopus 로고
    • Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (noni)
    • T. Akihisa, K. Matsumoto, H. Tokuda, K. Yashukawa, K.-i. Seino, and K. Nakamoto Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (noni) J Nat Prod 70 2007 754 757
    • (2007) J Nat Prod , vol.70 , pp. 754-757
    • Akihisa, T.1    Matsumoto, K.2    Tokuda, H.3    Yashukawa, K.4    Seino, K.-I.5    Nakamoto, K.6
  • 54
    • 0026736866 scopus 로고
    • Anthraquinones isolated from Morinda officinalis and Diacanthus indicus
    • Y.J. Yang, H.Y. Shu, and Z.D. Min Anthraquinones isolated from Morinda officinalis and Diacanthus indicus Yao Xue Xue Bao 27 1992 358 364
    • (1992) Yao Xue Xue Bao , vol.27 , pp. 358-364
    • Yang, Y.J.1    Shu, H.Y.2    Min, Z.D.3
  • 56
    • 0025361213 scopus 로고    scopus 로고
    • Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms
    • H. Mori, N. Yoshimi, H. Iwata, Y. Mori, A. Hara, and T. Tanaka Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms Carcinogenesis 11 1998 799 802
    • (1998) Carcinogenesis , vol.11 , pp. 799-802
    • Mori, H.1    Yoshimi, N.2    Iwata, H.3    Mori, Y.4    Hara, A.5    Tanaka, T.6
  • 58
    • 77953232726 scopus 로고    scopus 로고
    • Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats
    • G.D. Stoner, L.-S. Wang, C. Seguin, C. Rocha, K. Stoner, and S. Chiu Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats Pharm Res 27 2010 1138 1145
    • (2010) Pharm Res , vol.27 , pp. 1138-1145
    • Stoner, G.D.1    Wang, L.-S.2    Seguin, C.3    Rocha, C.4    Stoner, K.5    Chiu, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.