Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms

Carcinogenesis

Volumn 11, Issue 5, 1990, Pages 799-802

  Mori, Hideki ^a   Yoshimi, Naoki ^a   Iwata, Hitoshi ^a   Mori, Yoshio ^a   Hara, Akira ^a   Tanaka, Takuji ^a   Kawai, Kiyoshi ^b  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Chukyo Women's University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; NATURAL PRODUCT;

1 HYDROXYANTHRAQUINONE; ANIMAL EXPERIMENT; ARTICLE; COLON CARCINOGENESIS; HISTOLOGY; LIVER CARCINOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH CARCINOGENESIS;

ANIMAL; ANTHRAQUINONES; BODY WEIGHT; COLONIC NEOPLASMS; LIVER NEOPLASMS; MALE; RATS; STOMACH NEOPLASMS;

EID: 0025361213     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/11.5.799     Document Type: Article

References (25)

1. Hiatt, H.H., Watson, J.D and Wirrsten, J. A. (eds) (1977) Origins of Human Cancer. Cold Spnng Harbor Laboratory Press, Cold Spring Harbor, NY
2. Ames, B.N. (1979) Identifying environmental chemicals causing mutations and cancer. Science, 204, 587-593.
3. Miller, D.M., Miller, I.A., Hirono, I., Sugimura, T. and Takayama, S. (eds) (1979) Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogens. Jpn Scientific Societies Press, Tokyo and University Park Press, Baltimore.
4. Brown, J.P. (1980) A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutât. Res., 75, 243-277.
5. Hirono, I. (ed.) (1987) Naturally Occurring Carcinogens of Plant Origin. Bioactive Molecules, 2, Kodansha, Tokyo and Elsevier, Amsterdam.
6. Brown, J.P. and Brown, R J. (1976) Mutagenesis by 9,10-anthraquinone derivatives and related compounds in Salmonella typhtmurium Mutât. Res, 40, 203-224.
7. Tikkanen, L., Matsushima, T. and Naton, S. (1983) Mutagenicity of anthraquinones in the Salmonella preincubation test. Mutât. Res., 116, 297-304
8. Masuda, T. and Ueno, Y. (1984) Microsomal transformation of emodin into a direct mutagen Mutât. Res., 125, 135-144.
9. Os, F.H.L. (1976) Some aspects of the pharmacology of anthraquinone drugs. Pharmacology, 14 (Suppl 1), 18-29.
10. Mon, H., Kawai, K., Ohbayashi, F, Kuniyasu, T., Yamazaki, M., Hamasaki, T. and Williams, G.M. (1984) Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes Cancer Res., 44, 2918-2923.
11. Mori, H., Sugie, S., Niwa, K., Takahashi, M and Kawai, K. (1986) Induction of intestinal tumours in rats by chrysazin. Br. J. Cancer, 52, 781-783.
12. Mon, H., Sugie, S., Niwa, K., Yoshimi, N, Tanaka, T and Hirono, I. (1986) Carcinogenicity of chrysazin in large intestine and liver of mice Jpn. J. Cancer Res. Gann, 77, 871-876.
13. Burnett, A.R. and Thomson, R.H. (1967) Naturally occurring quinones. Part X. The quinonoid constituents of Tabebuia avellaenedae (Bignomaceae). J Chem. Soc., 2100-2104.
14. Kariyone, T. (1965) Pharmacognosy. Hirokawa Press, Tokyo, p. 421.
15. Gebhardt, M. (1979) Erste vorläufige Ergebnisse einer Studie über die litholytische Wirksamkeit von Urol auf Calcium-oxalasteine, Fortschr. Urol Nephrol., Suppl. 14, 34-40.
16. Kawai, K., Mon, H., Sugie, S., Yoshimi, N., Inoue, T., Nakamura, T, Nozawa, Y. and Matsushima, T. (1986) Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones. Cell Biol. Toxicol., 2, 457-467.
17. Griswold, D.P. Jr, Cassey, A.E., Weisburger, E.K. and Weisburger, J.H. (1968) The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amino derivatives in young female Sprague-Dawley rats. Cancer Res., 28, 924-933.
18. Krishna-Murphey, A.S., Baker, J.R., Smith, E.R. and Wade, G.G. (1977) Development of hemangiosarcomas in B6C3F1 mice fed 2-methyl-1-mtro-anthraquinone. Int. J. Cancer, 19, 117-121.
19. Jang, J.J., Takahashi, M., Hasegawa, R., Furukawa, F., Toyoda, K., Sato, H., Miyakawa, Y. and Hayashi, Y (1987) Mammary and renal tumor induction by low doses of adriamycin Sprague-Dawley rats. Carcinogenesis, 8, 1149-1153.
20. Uraguchi, K. and Saito, M. (1972) Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochrotin. Food. Cosmei. Toxicol., 10, 193-207.
21. Swanbeck, G. (1966) Interactions between deoxyribonucleic acid and someanthracene and anthraquinone derivatives. Biochtm. Biophys. Acta, 123, 630-633.
22. Swanbeck, G. and Zetterberg, G. (1971) Studies on dithranol and diethranol-like compounds. I. Binding to nucleic acids. Acut Demt-Venereol., 51,44.
23. Ueno, Y., Platel, A. and Fromageot, P. (1967) Interaction entire pigments et acids necléiques. B. Interaction in vitro entre la lutéoskyrine et le DNA de thymus de Veau. Biochim. Biophys Acta, 134, 27-36.
24. Hartman, P.E. and Goldstein, M.A. (1989) Superoxide generation by photomediated redox cyclic of anthraquinones Environ. Mol. Mut, 14, 47.
25. Kawai, K., Mon, H., Hisada, K. and Nozawa, Y. (1986) Biotransformation of the carcinogen chrysazin by NADPH-microsome system. Res. Commun. Chem. Pathol. Pharmacol., 54, 217-226