PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes

Osteoarthritis and Cartilage

Volumn 19, Issue 2, 2011, Pages 213-221

  Wang, D ^a,b   Taboas, J M ^a,c   Tuan, R S ^a,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Articular cartilage; Chondroprotection; Hypertrophy; Parathyroid hormone related peptide; Tensile strain

Indexed keywords

AGGRECAN; AGGRECANASE 1; AGGRECANASE 2; COLLAGEN TYPE 10; COLLAGEN TYPE 2; COLLAGENASE 3; CONNECTIVE TISSUE GROWTH FACTOR; CYCLOOXYGENASE 2; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERSTITIAL COLLAGENASE; MESSENGER RNA; NITRIC OXIDE; PARATHYROID HORMONE RELATED PROTEIN; PROSTAGLANDIN E2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL ELONGATION; CHONDROPROTECTION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME IMMUNOASSAY; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; MUSCULOSKELETAL INJURY; NONHUMAN; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TENSILE STRENGTH; TISSUE ENGINEERING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; GENE EXPRESSION REGULATION; NITRIC OXIDE; PARATHYROID HORMONE-RELATED PROTEIN; PHENOTYPE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL; TRANSFECTION;

EID: 79151481768     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.11.003     Document Type: Article

References (50)

1. Steinert A.F., Ghivizzani S.C., Rethwilm A., Tuan R.S., Evans C.H., Noth U. Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther 2007, 9:213.
2. Brittberg M., Lindahl A., Nilsson A., Ohlsson C., Isaksson O., Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994, 331:889-895.
3. Buckwalter J.A., Mankin H.J. Instructional course lectures, The American Academy of Orthopaedic Surgeons - articular cartilage. Part II: degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg Am 1997, 79:612-632.
4. Bullough P.G. The pathology of osteoarthritis. Osteoarthritis 1992, 39-70. Saunders, Philadelphia. R.W. Moskowitz, V.M. Goldberg, M.C. Hochberg (Eds.).
5. Djouad F., Rackwitz L., Song Y., Janjanin S., Tuan R.S. ERK1/2 activation induced by inflammatory cytokines compromises effective host tissue integration of engineered cartilage. Tissue Eng Part A 2009, 15:2825-2835.
6. Brandt K.D., Myers S.L., Burr D., Albrecht M. Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. Arthritis Rheum 1991, 34:1560-1570.
7. Radin E.L., Martin R.B., Burr D.B., Caterson B., Boyd R.D., Goodwin C. Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res 1984, 2:221-234.
8. Goldring M.B., Goldring S.R. Osteoarthritis. J Cell Physiol 2007, 213:626-634.
9. Kirsch T., Swoboda B., Nah H. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthritis Cartilage 2000, 8:294-302.
10. Tchetina E.V., Squires G., Poole A.R. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 2005, 32:876-886.
11. Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54:3533-3544.
12. Wang X., Manner P.A., Horner A., Shum L., Tuan R.S., Nuckolls G.H. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 2004, 12:963-973.
13. Vortkamp A., Lee K., Lanske B., Segre G.V., Kronenberg H.M., Tabin C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996, 273:613-622.
14. Bastepe M., Weinstein L.S., Ogata N., Kawaguchi H., Juppner H., Kronenberg H.M., et al. Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo. Proc Natl Acad Sci U S A 2004, 101:14794-14799.
15. Huang W., Chung U.I., Kronenberg H.M., de Crombrugghe B. The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci U S A 2001, 98:160-165.
16. Amling M., Neff L., Tanaka S., Inoue D., Kuida K., Weir E., et al. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 1997, 136:205-213.
17. Henderson J.E., Amizuka N., Warshawsky H., Biasotto D., Lanske B.M., Goltzman D., et al. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol 1995, 15:4064-4075.
18. Steinert A.F., Noth U., Tuan R.S. Concepts in gene therapy for cartilage repair. Injury 2008, 39(Suppl 1):S97-113.
19. Thirion S., Berenbaum F. Culture and phenotyping of chondrocytes in primary culture. Cartilage and osteoarthritis: volume 1: cellular and molecular tools 2004, 1-14. Humana Press, New York. M. Sabatini, P. Pastoureau, F. Ceuninck (Eds.).
20. Madry H., Trippel S.B. Efficient lipid-mediated gene transfer to articular chondrocytes. Gene Ther 2000, 7:286-291.
21. Ditmer L.S., Burton D.W., Deftos L.J. Elimination of the carboxy-terminal sequences of parathyroid hormone-related protein 1-173 increases production and secretion of the truncated forms. Endocrinology 1996, 137:1608-1617.
22. Pfander D., Swoboda B., Kirsch T. Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Am J Pathol 2001, 159:1777-1783.
23. Aigner T., Kim H.A., Roach H.I. Apoptosis in osteoarthritis. Rheum Dis Clin North Am 2004, 30:639-653. xi.
24. Ballock R.T., Heydemann A., Wakefield L.M., Flanders K.C., Roberts A.B., Sporn M.B. TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases. Dev Biol 1993, 158:414-429.
25. Tchetina E., Mwale F., Poole A.R. Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. J Bone Miner Res 2003, 18:844-851.
26. Dean D.D., Muniz O.E., Berman I., Pita J.C., Carreno M.R., Woessner J.F., et al. Localization of collagenase in the growth plate of rachitic rats. J Clin Invest 1985, 76:716-722.
27. Cawston T.E., Wilson A.J. Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol 2006, 20:983-1002.
28. Vu T.H., Shipley J.M., Bergers G., Berger J.E., Helms J.A., Hanahan D., et al. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 1998, 93:411-422.
29. Orloff J.J., Reddy D., de Papp A.E., Yang K.H., Soifer N.E., Stewart A.F. Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions. Endocr Rev 1994, 15:40-60.
30. Wysolmerski J.J., Stewart A.F. The physiology of parathyroid hormone-related protein: an emerging role as a developmental factor. Annu Rev Physiol 1998, 60:431-460.
31. Kronenberg H.M. PTHrP and skeletal development. Ann N Y Acad Sci 2006, 1068:1-13.
32. Jiang J., Leong N.L., Mung J.C., Hidaka C., Lu H.H. Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP. Osteoarthritis Cartilage 2008, 16:70-82.
33. Chang J.K., Chang L.H., Hung S.H., Wu S.C., Lee H.Y., Lin Y.S., et al. Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats. Arthritis Rheum 2009, 60:3049-3060.
34. Aarts M.M., Davidson D., Corluka A., Petroulakis E., Guo J., Bringhurst F.R., et al. Parathyroid hormone-related protein promotes quiescence and survival of serum-deprived chondrocytes by inhibiting rRNA synthesis. J Biol Chem 2001, 276:37934-37943.
35. Okoumassoun L., Averill-Bates D., Denizeau F., Henderson J.E. Parathyroid hormone related protein (PTHrP) inhibits TNFalpha-induced apoptosis by blocking the extrinsic and intrinsic pathways. J Cell Physiol 2007, 210:507-516.
36. Okoumassoun L.E., Russo C., Denizeau F., Averill-Bates D., Henderson J.E. Parathyroid hormone-related protein (PTHrP) inhibits mitochondrial-dependent apoptosis through CK2. J Cell Physiol 2007, 212:591-599.
37. Henry J.G., Mitnick M., Dann P.R., Stewart A.F. Parathyroid hormone-related protein-(1-36) is biologically active when administered subcutaneously to humans. J Clin Endocrinol Metab 1997, 82:900-906.
38. Terkeltaub R., Lotz M., Johnson K., Deng D., Hashimoto S., Goldring M.B., et al. Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate. Arthritis Rheum 1998, 41:2152-2164.
39. Okano K., Tsukazaki T., Ohtsuru A., Osaki M., Yonekura A., Iwasaki K., et al. Expression of parathyroid hormone-related peptide in human osteoarthritis. J Orthop Res 1997, 15:175-180.
40. Gomez-Barrena E., Sanchez-Pernaute O., Largo R., Calvo E., Esbrit P., Herrero-Beaumont G. Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis. Ann Rheum Dis 2004, 63:917-922.
41. Mattot V., Raes M.B., Henriet P., Eeckhout Y., Stehelin D., Vandenbunder B., et al. Expression of interstitial collagenase is restricted to skeletal tissue during mouse embryogenesis. J Cell Sci 1995, 108(Pt 2):529-535.
42. Goldring M.B., Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 2004, 427(Suppl):S37-S46.
43. Kalinowski L., Dobrucki L.W., Malinski T. Nitric oxide as a second messenger in parathyroid hormone-related protein signaling. J Endocrinol 2001, 170:433-440.
44. Yoshida T., Horiuchi T., Sakamoto H., Inoue H., Takayanagi H., Nishikawa T., et al. Production of parathyroid hormone-related peptide by synovial fibroblasts in human osteoarthritis. FEBS Lett 1998, 433:331-334.
45. Yoshida T., Sakamoto H., Horiuchi T., Yamamoto S., Suematsu A., Oda H., et al. Involvement of prostaglandin E(2) in interleukin-1alpha-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis. J Clin Endocrinol Metab 2001, 86:3272-3278.
46. Cheung J.O., Grant M.E., Jones C.J., Hoyland J.A., Freemont A.J., Hillarby M.C. Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. J Pathol 2003, 201:496-503.
47. van de Loo F.A., de Hooge A.S., Smeets R.L., Bakker A.C., Bennink M.B., Arntz O.J., et al. An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint. Gene Ther 2004, 11:581-590.
48. Geurts J., Arntz O.J., Bennink M.B., Joosten L.A., van den Berg W.B., van de Loo F.A. Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis. Gene Ther 2007, 14:1632-1638.
49. Rachakonda P.S., Rai M.F., Schmidt M.F. Application of inflammation-responsive promoter for an in vitro arthritis model. Arthritis Rheum 2008, 58:2088-2097.
50. Guo J., Chung U.I., Kondo H., Bringhurst F.R., Kronenberg H.M. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell 2002, 3:183-194.