Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats

Arthritis and Rheumatism

Volumn 60, Issue 10, 2009, Pages 3049-3060

  Chang, Je Ken ^a   Chang, Ling Hwa ^a   Hung, Shao Hung ^a,b   Wu, Shun Cheng ^a   Lee, Hsin Yi ^a   Lin, Yi Shan ^a   Chen, Chung Hwan ^a   Fu, Yin Chih ^a   Wang, Gwo Jaw ^a   Ho, Mei Ling ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b FOOYIN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; ALKALINE PHOSPHATASE; AZACITIDINE; COLLAGEN TYPE 10; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN; MESSENGER RNA; PAPAIN; PARATHYROID HORMONE[1-34]; PROTEIN BAX; PROTEIN BCL 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SOX9;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FEMALE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; MALE; MORPHOMETRICS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADULT; ANIMALS; AZACITIDINE; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHONDROCYTES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME INHIBITORS; FEMALE; GLYCOSAMINOGLYCANS; HUMANS; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; OSTEOARTHRITIS; PAPAIN; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 70349771969     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24843     Document Type: Article

References (44)

1. Hamerman D. Clinical implications of osteoarthritis and ageing. Ann Rheum Dis 1995;54:82-85
2. Hamerman D. The biology of osteoarthritis. N Engl J Med 1989;320:1322-1330
3. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-97 (Pubitemid 32102197)
4. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ, Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 1998;41:284-289 (Pubitemid 28087696)
5. Kirsch T, Swoboda B, Nah H. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Osteoarthritis Cartilage 2000;8: 294-302. (Pubitemid 30620192)
6. Horton WE Jr, Feng L, Adams C. Chondrocyte apoptosis in development, aging and disease. Matrix Biol 1998;17:107-115 (Pubitemid 28310245)
7. Weisser J, Riemer S, Schmidl M, Suva LJ, Poschl E, Brauer R, et al. Four distinct chondrocyte populations in the fetal bovine growth plate: highest expression levels of PTH/PTHrP receptor, Indian hedgehog, and MMP-13 in hypertrophic chondrocytes and their suppression by PTH (1-34) and PTHrP (1-40). Exp Cell Res 2002;279:1-13.
8. Kronenberg HM, Lanske B, Kovacs CS, Chung UI, Lee K, Segre GV, et al. Functional analysis of the PTH/PTHrP network of ligands and receptors. Recent Prog Horm Res 1998;53:283-301. (Pubitemid 128472745)
9. Strewler GJ. Local and systemic control of the osteoblast. J Clin Invest 2001;107:271-272
10. Onyia JE, Bidwell J, Herring J, Hulman J, Hock JM. In vivo, human parathyroid hormone fragment (hPTH 1-34) transiently stimulates immediate early response gene expression, but not proliferation, in trabecular bone cells of young rats. Bone 1995; 17:479-484
11. Ho ML, Chang JK, Wu SC, Chung YH, Chen CH, Hung SH, et al. A novel terminal differentiation model of human articular chondrocytes in three-dimensional cultures mimicking chondrocytic changes in osteoarthritis. Cell Biol Int 2006;30:288-294
12. Cheung JO, Hillarby MC, Ayad S, Hoyland JA, Jones CJ, Denton J, et al. A novel cell culture model of chondrocyte differentiation during mammalian endochondral ossification. J Bone Miner Res 2001;16:309-318 (Pubitemid 32105412)
13. Huang MH, Ding HJ, Yang CC, Chai CY, Yang RC. The early evaluation of induced osteoarthritis in rats with 99Tcm-pertechnetate scans. Nucl Med Commun 1996;17:529-535
14. Shang L, Qin J, Chen LB, Liu BX, Jacques M, Wang H. Effects of sodium ferulate on human osteoarthritic chondrocytes and osteoarthritis in rats. Clin Exp Pharmacol Physiol 2009. E-pub ahead of print.
15. Murat N, Karadam B, Ozkal S, Karatosun V, Gidener S. Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score. Acta Orthop Traumatol Turc 2007;41: 233-7. In Turkish.
16. Tallheden T, Bengtsson C, Brantsing C, Sjogren-Jansson E, Carlsson L, Peterson L, et al. Proliferation and differentiation potential of chondrocytes from osteoarthritic patients. Arthritis Res Ther 2005;7:R560-8.
17. Sanchez C, Mateus MM, Defresne MP, Crielaard JM, Reginster JY, Henrotin YE. Metabolism of human articular chondrocytes cultured in alginate beads: longterm effects of interleukin 1β and nonsteroidal antiinflammatory drugs. J Rheumatol 2002;29: 772-782 (Pubitemid 34303873)
18. Morrison TB, Weis JJ, Wittwer CT. Quantification of low-copy transcripts by continuous SYBR Green I monitoring during amplification. Biotechniques 1998;24:954-8, 960, 962.
19. T method. Methods 2001;25:402-408
20. Naumann A, Dennis JE, Awadallah A, Carrino DA, Mansour JM, Kastenbauer E, et al. Immunochemical and mechanical characterization of cartilage subtypes in rabbit. J Histochem Cytochem 2002;50:1049-1058 (Pubitemid 34827627)
21. Chase LR, Aurbach GD. The effect of parathyroid hormone on the concentration of adenosine 3′,5′-monophosphate in skeletal tissue in vitro. J Biol Chem 1970;245:1520-1526
22. Schiller PC, D'Ippolito G, Roos BA, Howard GA. Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment. J Bone Miner Res 1999;14:1504-1512 (Pubitemid 29416676)
23. Whitfield JF, Morley P, Willick GE. Parathyroid hormone, its fragments and their analogs for the treatment of osteoporosis. Treat Endocrinol 2002;1:175-190 (Pubitemid 36828425)
24. Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, et al. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res 2002;17:2038-2047 (Pubitemid 35239205)
25. Stewart AF, Cain RL, Burr DB, Jacob D, Turner CH, Hock JM. Six-month daily administration of parathyroid hormone and parathyroid hormone-related protein peptides to adult ovariectomized rats markedly enhances bone mass and biomechanical properties: a comparison of human parathyroid hormone 1-34, parathyroid hormone-related protein 1-36, and SDZ-parathyroid hormone 893. J Bone Miner Res 2000;15:1517-1525 (Pubitemid 30484521)
26. Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A 1992;89:2732-2736
27. Selvamurugan N, Pulumati MR, Tyson DR, Partridge NC. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor α1. J Biol Chem 2000;275:5037-5042 (Pubitemid 30108902)
28. Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M, Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and β-arrestins. Endocrinology 2002;143:3854-3865 (Pubitemid 35244365)
29. Fujimori A, Cheng SL, Avioli LV, Civitelli R. Dissociation of second messenger activation by parathyroid hormone fragments in osteosarcoma cells. Endocrinology 1991;128:3032-3039
30. Caulfield MP, McKee RL, Goldman ME, Duong LT, Fisher JE, Gay CT, et al. The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: the receptor binding domains of PTH and PTH-related protein are located within the 14-34 region. Endocrinology 1990;127:83-87
31. Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 1994;8:277-289 (Pubitemid 24065970)
32. Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci U S A 1996;93: 10240-10245 (Pubitemid 26314606)
33. Rabie AB, Tang GH, Xiong H, Hagg U. PTHrP regulates chondrocyte maturation in condylar cartilage. J Dent Res 2003;82: 627-631 (Pubitemid 41766146)
34. Lee K, Deeds JD, Segre GV. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 1995;136:453-463
35. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996;273:613-622 (Pubitemid 26262108)
36. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, et al. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 1997;136:205-213 (Pubitemid 27044815)
37. Huang W, Chung UI, Kronenberg HM, de Crombrugghe B. The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Proc Natl Acad Sci U S A 2001;98:160-165 (Pubitemid 32095880)
38. Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, et al. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res 2004;299:128-136 (Pubitemid 39078388)
39. Gomez-Barrena E, Sanchez-Pernaute O, Largo R, Calvo E, Esbrit P, Herrero-Beaumont G. Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis. Ann Rheum Dis 2004;63:917-922 (Pubitemid 38961915)
40. Jiang J, Leong NL, Mung JC, Hidaka C, Lu HH. Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP. Osteoarthritis Cartilage 2008;16:70-82.
41. Harvey AK, Yu XP, Frolik CA, Chandrasekhar S. Parathyroid hormone-(1-34) enhances aggrecan synthesis via an insulin-like growth factor-I pathway. J Biol Chem 1999;274:23249-23255
42. Mizuta H, Kudo S, Nakamura E, Takagi K, Hiraki Y. Expression of the PTH/PTHrP receptor in chondrogenic cells during the repair of full-thickness defects of articular cartilage. Osteoarthritis Cartilage 2006;14:944-952 (Pubitemid 44138674)
43. Chen X, Macica CM, Nasiri A, Broadus AE. Regulation of articular chondrocyte proliferation and differentiation by Indian hedgehog and parathyroid hormone-related protein in mice. Arthritis Rheum 2008;58:3788-3797
44. Cheung JO, Grant ME, Jones CJ, Hoyland JA, Freemont AJ, Hillarby MC. Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. J Pathol 2003;201: 496-503.