Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

Free Radical Biology and Medicine

Volumn 50, Issue 3, 2011, Pages 448-458

  Case, Adam J ^a   McGill, Jodi L ^a   Tygrett, Lorraine T ^a   Shirasawa, Takuji ^b   Spitz, Douglas R ^a   Waldschmidt, Thomas J ^a   Legge, Kevin L ^a   Domann, Frederick E ^a  

^a UNIVERSITY OF IOWA   (United States)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Adaptive immunity; Antioxidants; Apoptosis; Cre loxP; Developmental biology; Free radicals; Immunodeficiency; Influenza; Manganese superoxide dismutase; Mouse; Superoxide; Transgenic

Indexed keywords

SUPEROXIDE DISMUTASE;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; FEMALE; IMMUNE DEFICIENCY; INFECTION SENSITIVITY; INFLUENZA; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ANIMALS; APOPTOSIS; FEMALE; GENE KNOCKOUT TECHNIQUES; INFLUENZA A VIRUS, H1N1 SUBTYPE; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; ORTHOMYXOVIRIDAE INFECTIONS; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; SUPEROXIDES; T-LYMPHOCYTES;

DANIO RERIO; INFLUENZA A VIRUS; MAMMALIA; MURINAE;

EID: 79151479868     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.11.025     Document Type: Article

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