Protective effect of ursolic acid on ethanol-mediated experimental liver damage in rats

Life Sciences

Volumn 78, Issue 7, 2006, Pages 713-718

  Saravanan, Rajendrasozhan ^a   Viswanathan, Periyaswamy ^a   Pugalendi, Kodukkur Viswanathan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; Ethanol; Lipid peroxidation; Liver; Silymarin; Ursolic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALCOHOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE; LIPID HYDROPEROXIDE; PLASMA PROTEIN; SILYMARIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; URSOLIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; ENZYME ACTIVITY; FOOD INTAKE; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT;

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CHEMOPREVENTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; DRUG THERAPY, COMBINATION; EATING; ETHANOL; HEPATOCYTES; LIPID PEROXIDATION; LIVER DISEASES, ALCOHOLIC; MALE; RATS; RATS, WISTAR; SILYMARIN; TRANSAMINASES; TRITERPENES;

ANIMALIA;

EID: 29244460388     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.05.060     Document Type: Article

References (41)

1. B. Ahmed, T. Alam, M. Varshney, and A.S. Khan Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family Journal of Ethnopharmacology 79 3 2002 313 316
2. H. Baker, O. Frank, B. DeAngelis, and S. Feingold Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol Nutrition Research 21 1980 531 536
3. E. Baldi, P. Burra, M. Plebani, and M. Salvagnini Serum malondialdehyde and mitochondrial aspartate aminotransferase activity as markers of chronic alcohol intake and alcoholic liver disease Italian Journal of Gastroenterology 25 8 1993 429 432
4. G.A. Bjorneboe, J. Johnsen, A. Bjorneboe, J. Morland, and C.A. Drevon Effect of heavy alcohol consumption on serum concentration of fat-soluble vitamins and selenium Alcohol and Alcoholism 1 1987 533 537
5. Q. Chen, H. Shi, and C.T. Ho Effect of rosemary extracts and major constituents on lipid oxidation and soybean lipoxygenase activity Journal of the American Oil Chemists' Society 69 1992 999 1002
6. A.M. Diehl Liver disease in alcohol abusers: clinical perspective Alcohol 27 1 2002 7 11
7. G.L. Ellman Tissue sulfhydryl groups Archives of Biochemistry and Biophysics 82 1 1959 70 77
8. R.B. Friedman, R.E. Anderson, S.M. Entine, and S.B. Hirshberg Effects of diseases on clinical laboratory tests Clinical Chemistry 26 Suppl. 4 1980 1D 476D
9. K.H. Gan, and C.N. Lin Studies on the constituents of Gentiana flavomaculata and Tripterospermum taiwanense and the antihepatotoxic activity of ursolic acid derivatives The Chinese Pharmaceutical Journal 40 1988 77 84
10. D.M. Goldberg, and C. Watts Serum enzyme changes as evidence of liver reaction to oral alcohol Gastroenterology 49 3 1965 256 261
11. C. Guerri, and S. Grisolia Influence of prolonged ethanol intake on the levels and turnover of alcohol and aldehyde dehydrogenase and glutathione Advances in Experimental Medicine and Biology 126 1980 365 384
12. H.A. Harper The functions and tests of the liver Review of Physiological Chemistry 1961 Lange Medical Publishers Los Atlos, CA 271 283
13. Z.Y. Jiang, J.V. Hunt, and S.P. Wolff Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein Analytical Biochemistry 202 2 1992 384 389
14. J.S. Kim, J.I. Huh, S.H. Song, K.H. Shim, B.S. Back, K.W. Kim, K.Y. Lee, and H.Y. Chung The antioxidative mechanism of ursolic acid Korean Journal of Gastroenterology 6 1996 52 56
15. K. Kitani Hepatoprotective effect of ursodeoxycholate in experimental animals G. Paumgartner Strategies for the Treatment of Hepatobiliary Diseases 1990 Kluwer Lancaster 43 56
16. K. Kitani, S. Kanai, O.I. Ivy, and M.C. Carrillo Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy Mechanism of Ageing and Development 111 1999 211 221
17. C.N. Lin, M.I. Chung, and K.H. Gan Novel antihepatotoxic principles of Solanum incanum Planta Medica 54 3 1988 222
18. K.O. Lindros Alcoholic liver disease: pathobiological aspects Journal of Hepatology 23 Suppl. 1 1995 7 15
19. J. Liu Pharmacology of oleanolic acid and ursolic acid Journal of Ethnopharmacology 49 1995 57 68
20. X.H. Ma, Y.C. Zhao, L. Yin, D.W. Han, and M.S. Wang Studies on the preventive and therapeutic effects of ursolic acid on acute hepatic injury in rats Acta Pharmacologica Sinica 21 1986 332 335
21. R.N MacSween, and A.D. Burt Histologic spectrum of alcoholic liver disease Seminars in Liver Disease 6 3 1986 221 232
22. S.B. Mahato, S.K. Sarkar, and G. Poddar Triterpenoid saponins Phytochemistry 27 1988 3037 3067
23. H.T. Malloy, and K.A. Evelyn The determination of bilirubin with the photoelectric colorimeter The Journal of Biological Chemistry 119 112 1937 481 490
24. S. Martin-Aragon, B. De Las Heras, M.I. Sanchez-Reus, and J. Benedi Pharmacological modification of endogenous antioxidative enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes Experimental and Toxicologic Pathology 53 2001 199 206
25. National Institute of Health, 1985. Guide for the Care and Use of Laboratory Animals. DHEN Publication (NIH). Office of Science and Health Reports, DRR/NIH, Bethesda, MD, publication no. 85-23.
26. W.G. Nichans, and B. Samuelson Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation European Journal of Biochemistry 6 1 1968 126 130
27. R. Nordmann Alcohol and antioxidant systems Alcohol and Alcoholism 29 5 1994 513 522
28. R. Nordmann, C. Ribiere, and H. Rouach Implication of free radical mechanisms in ethanol-induced cellular injury Free Radical Biology & Medicine 12 3 1992 219 240
29. R.C. Pirola, and C.S. Lieber Energy wastage in rats given drugs that induce microsomal enzymes Journal of Nutrition 105 12 1975 1544 1548
30. K.R. Price, I.T. Johnson, and G.R. Fenwick The chemistry and biological significance of saponins in foods and feedingstuffs Critical Reviews in Food Science and Nutrition 26 1 1987 27 135
31. Z. Rakonczay Jr., I. Boros, K. Jarmay, P. Hegyi, J. Lonovics, and T. Takacs Ethanol administration generates oxidative stress in the pancreas and liver, but fails to induce heat-shock proteins in rats Journal of Gastroenterology and Hepatology 18 7 2003 858 867
32. J.G. Reinhold Manual determination of serum total protein, albumin and globulin fractions by Biuret method M. Reiner Standard Methods in Clinical Chemistry 1953 Academic Press New York 88
33. S. Reitman, and S. Frankel A colorimetric method for the determination of serum glutamate oxaloacetic and glutamate pyruvic transaminases American Journal of Clinical Pathology 28 1 1957 56 63
34. J.H. Roe, and C.A. Kuether The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid The Journal of Biological Chemistry 11 1943 145 164
35. B. Saraswat, P.K.S. Visen, and D.P. Agarwal Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes Phytotherapy Research 14 2000 163 166
36. S.N. Sarkar, S.K. Chattopadhyay, and A.C. Majumdar Subacute toxicity of urea herbicide, isoproturon in male rats Indian Journal of Experimental Biology 33 11 1995 851 856
37. B. Shukla, P.K.S. Visen, G.K. Patnaik, S.C. Tripathi, R.C. Srimal, R. Dayal, and P.C. Dobhal Hepatoprotective activity in the rate of ursolic acid isolated from Eucalyptus hybrid Phytotherapy Research 6 1992 74 79
38. A.D. Thomson, H. Baker, and C.M. Leevy Patterns of 35S-thiamin hydrochloride absorption in the malnourished alcoholic patients Journal of Laboratory and Clinical Medicine 76 1 1970 34 45
39. H. Wefers, and H. Sies The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E European Journal of Biochemistry 174 2 1988 353 357
40. B.P. Yu Cellular defenses against damage from reactive oxygen species Physiological Reviews 74 1 1994 139 162
41. T. Zima, L. Fialova, O. Mestek, M. Janebova, J. Crkovska, I. Malbohan, S. Stipek, L. Mikulikova, and P. Popov Oxidative stress, metabolism of ethanol and alcohol-related diseases Journal of Biomedical Science 8 1 2001 59 70