Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling

Biochemical Pharmacology

Volumn 78, Issue 3, 2009, Pages 301-314

  Szuster Ciesielska, Agnieszka ^a   Plewka, Krzysztof ^a   Daniluk, Jadwiga ^b   Kandefer Szerszeń, Martyna ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Cytokines; Liver stellate cells; MAPK; NF B; Zinc

Indexed keywords

4 METHYL PYRAZOLE; ACETALDEHYDE; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; CANCER GROWTH FACTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; PYRAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; VITAMIN SUPPLEMENTATION;

ACETALDEHYDE; ACTINS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE; COLLAGEN TYPE I; ENZYME ACTIVATION; ETHANOL; LIVER; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PROTEIN KINASE C; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; ZINC;

EID: 65749117033     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.04.009     Document Type: Article

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