Synthesis and antibacterial evaluation of novel clarithromycin derivatives with C-4″ elongated arylalkyl groups against macrolide-resistant strains

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 556-566

  Ma, Shutao ^a   Jiao, Bo ^a   Ju, Yongjing ^a   Zheng, Manjie ^a   Ma, Ruixin ^b   Liu, Lin ^a   Zhang, Ling ^a   Shen, Xuecui ^a   Ma, Chenchen ^a   Meng, Ya ^a   Wang, Hui ^c   Qi, Yunkun ^a   Ma, Xiaodong ^a   Cui, Wenping ^a  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Antibacterial activity; Clarithromycin derivatives; Macrolide resistant strains; Synthesis

Indexed keywords

4' O (3,4 METHYLENEDIOXYPHENETHYL)CARBAMOYLCLARITHROMYCIN; 4' O (BUTYL)CARBAMOYLCLARITHROMYCIN; 4' O (PENTYL)CARBAMOYLCLARITHROMYCIN; 4' O (PHENETHYL)CARBAMOYLCLARITHROMYCIN; 4' O (PROPENYL)CARBAMOYLCLARITHROMYCIN; 4' O (PROPYL)CARBAMOYLCLARITHROMYCIN; 4' O [[(2 CHLOROPHENETHYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(4 FLUOROBENZYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(4 FLUOROBENZYL)AMINO] 6 OXO HEXYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(4 HYDROXYPHENETHYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(4 METHOXYBENZYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(BENZYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(BENZYL)AMINO] 6 OXO HEXYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(BUTYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(CYCLOHEXYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(ISOPROPYL)AMINO 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(PENTYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(PROPENYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(PROPYL)AMINO) 6 OXO HEXYL]CARBAMOYLCLARITHROMYCIN; 4' O [[(PROPYL)AMINO] 4 OXO BUTYL]CARBAMOYLCLARITHROMYCIN; 4'' O (2 CHLOROPHENETHYL)CARBAMOYLCLARITHROMYCIN; 4'' O (4 FLUOROBENZYL)CARBAMOYLCLARITHROMYCIN; 4'' O (4 HYDROXYPHENETHYL)CARBAMOYLCLARITHROMYCIN; 4'' O (4 METHOXYBENZYL)CARBAMOYLCLARITHROMYCIN; 400 O [[(ISOPROPYL)AMINO] 6 OXO HEXYL]CARBAMOYLCLARITHROMYCIN; ANTIBIOTIC AGENT; BENZENE; CLARITHROMYCIN DERIVATIVE; ERYTHROMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151472201     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.035     Document Type: Article

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