Structure-activity relationships for six ketolide antibiotics

Current Microbiology

Volumn 42, Issue 3, 2001, Pages 203-210

  Champney, W Scott ^a   Tober, Craig L ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETHROMYCIN; HMR 3004; HMR 3562; HMR 3787; HMR 3832; KETOLIDE; MACROLIDE; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; IC 50; NONHUMAN; PRIORITY JOURNAL; RIBOSOME SUBUNIT; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0035112554     PISSN: 03438651     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002840     Document Type: Article

References (50)

1. Antibiotic resistance
2. Gram-positive resistance: Challenge for the development of new antibiotics
3. B resistance phenotype
4. In vitro activity of two ketolides, HMR 3562 and HMR 3787, against respiratory pathogens
5. In vivo antibacterial activity of two ketolides HMR 3562 and HMR 3787 highly active against respiratory pathogens
6. In vitro activity of ABT-773, a new ketolide antibiotic, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis
7. Ketolides: New semisynthetic 14-membered macrolides
8. Antibacterial effects of ABT-773 against respiratory tract pathogens
9. Mechanism of action for novel ketolide ABT-773
10. Macrolide antibiotic inhibition of 50S ribosomal subunit formation in bacterial cells
11. 50S Ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus
12. Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells
13. Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by eleven different ketolide antibiotics
14. Superiority of 11,12 carbonate macrolide antibiotics as inhibitors of translation and 50S subunit formation in Staphylococcus aureus cells
15. A comparison of the inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by nine different macrolide antibiotics
16. The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics
17. New directions in antibacterial research
18. Inhibition of protein synthesis by streptogramins and related antibiotics
19. Studies of the novel ketolide ABT-773: Transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae
20. Comparative antianaerobic activities of the ketolides HMR 3647 (RU66647) and HMR 3004 (RU 64004)
21. Erythromycin, clarithromycin and azithromycin: Use of frequency distribution curves, scattergrams and regression analyses to compare in vitro activities and describe cross-resistance
22. In vitro activity of two ketolides, HMR 3562 and HMR 3787, against clinical bacterial isolates
23. The bactericidal activities of HMR 3004, HM 3647 and erythromycin against gram-positive bacilli and development of resistance
24. In vitro activity of SCH27899 alone and in combination with 17 other antimicrobial agents
25. Antimicrobial-drug resistance
26. The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
27. Simplified agar plate method for quantifying viable bacteria
28. Antimicrobial activity of SCH 27899, oligosaccharide member of the everninomycin class with a wide gram-positive spectrum
29. Activity of ketolides HMR 3562 and HMR 3787 against erythromycin-sensitive (ery-s) and -resistant (ery-r) pneumococci in murine pneumonia models
30. Aromatic rings act as hydrogen bond acceptors
31. Design, synthesis and characterization of ABT-773: A novel ketolide highly active against multidrug resistant pathogens
32. In vitro activities of two ketolides, HMR 3647 and HMR 3004, against gram-positive bacteria
33. The intermolecular complex of erythromycin and the ribosome
34. Synergy testing of vancomycin-resistant Enterococcus faecium against quinupristin-dalfopristin in combination with other antimicrobial agents
35. Susceptibilities of penicillin- and erythromycin-susceptible and -resistant pneumococci to HMR 3647 (RU66647), a new ketolide, compared with susceptibilities of 19 other agents
36. Pronounced postantibiotic effect of quinupristin-dalfopristin in static cultures of Staphylococcus aureus: An effect not seen with other antibiotics
37. In vitro activity of a new ketolide, HMR3647, against Chlamydia pneumoniae
38. A non-inducer ketolide, HMR3004 (RU64004), active against streptococci inducibly cross-resistant to macrolides and lincomycin
39. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium
40. In vitro activity of ketolides HMR 3647 and HMR 3004, levofloxacin, and other quinolones and macrolides against Neisseria ssp. and Moraxella catarrthalis
41. The in vitro activity of ABT-773 against gram-positive and gramnegative pathogens
42. In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae
43. Occurrence and epidemiology of resistance to virginiamycin and streptogramins
44. Comparative in-vitro activity of SCH 27899, a novel everninomicin, and vancomycin
45. In vitro activity of the new ketolide HMR 3647 against gram-positive cocci either susceptible or resistant to erythromycin
46. A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre
47. In vitro activity of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pedicoccus isolates
48. Molecular basis of ABT-773 activity against erm-containing macrolide resistant S. pneumoniae