Synthesis and antibacterial activity of 4″,11-di-O-arylalkylcarbamoyl azithromycin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 6, 2009, Pages 1698-1701

  Ma, Shutao ^a   Jiao, Bo ^a   Liu, Zhaopeng ^a   Wang, Hui ^b   Xian, Ruiqing ^a   Zheng, Manjie ^a   Lou, Hongxiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

4 ,11 Disubstituted azithromycin; Antibacterial activity; Macrolide resistance; Synthesis

Indexed keywords

4'',11 DI O ARYLALKYLCARBAMOYLAZITHROMYCIN DERIVATIVE; ANTIINFECTIVE AGENT; AZITHROMYCIN; CLARITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BACTERIAL PROTEINS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; MACROLIDES; MEMBRANE PROTEINS; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE;

STREPTOCOCCUS PNEUMONIAE;

EID: 61349195336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.092     Document Type: Article

References (11)

1. Zhanel G.G., Dueck M., Hoban D.J., Vercaigne L.M., Embil J.M., Gin A.S., and Karlowsky J.A. Drugs 61 (2001) 443
2. Wu Y.J., and Su W.G. Curr. Med. Chem. 8 (2001) 1727
3. Zhanel G.G., Walters M., Noreddin A., Vercaigne L.M., Wierzbowski A., Embil J.M., Gin A.S., Douthwaite S., and Hobanl D.J. Drugs 62 (2002) 1771
4. Bryskier A. Clin. Infect. Dis. 27 (1998) 865
5. Weisblum B. Antimicrob. Agents Chemother. 39 (1995) 577
6. Niu, D. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, Sept 27-30, 2002, Abst F 1666.
7. Takashima H. Curr. Top. Med. Chem. 3 (2003) 991
8. Cheng, H.; Letavic, M. A.; Ziegler, C. B.; Dutra, J. K.; Bertinato, P.; Bronk, B. S. U.S. Patent 6,043,227, 2000.
9. Xian R., Ma S., and Jiao B. Chin. Chem. Lett. 19 (2008) 409
10. 15, 1012.3 [M+H].
11. 15, 1094.7 [M+H].