Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase

Journal of Biological Chemistry

Volumn 286, Issue 4, 2011, Pages 3047-3056

  Tomasiak, Thomas M ^a   Archuleta, Tara L ^a   Andréll, Juni ^b   Luna Chávez, César ^c   Davis, Tyler A ^a,d   Sarwar, Maruf ^e   Ham, Amy J ^a   Hayes McDonald, W ^a   Yankovskaya, Victoria ^c   Stern, Harry A ^e   Johnston, Jeffrey N ^a,d   Maklashina, Elena ^c,f   Cecchini, Gary ^c,f   Iverson, Tina M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e UNIVERSITY OF ROCHESTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; 3-NITROPROPIONATE; ACTIVATED BONDS; COMPUTATIONAL MODELING; DOUBLE BONDS; ELECTRONIC INTERACTIONS; FUMARATES; GEOMETRIC CONSTRAINT; GLUTARATE; INTERCONVERSIONS; NUCLEOPHILIC ATTACK; OPTICAL DIFFERENCE SPECTROSCOPY; ORBITAL OVERLAP; SMALL MOLECULES; SUBSTRATE BINDING; SUBSTRATE SPECIFICITY;

CARBOXYLATION; CATALYSIS; CHEMICAL ACTIVATION; ENZYME INHIBITION; ESCHERICHIA COLI;

SUBSTRATES;

3 NITROPROPIONIC ACID; FLAVOPROTEIN; FUMARATE REDUCTASE; GLUTARIC ACID; MENAQUINOL FUMARATE REDUCTASE; OXALOACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; ESCHERICHIA COLI; GEOMETRY; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; SPECTROSCOPY;

CATALYSIS; ELECTRON TRANSPORT COMPLEX II; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FUMARATES; MODELS, CHEMICAL; MODELS, MOLECULAR; OXIDOREDUCTASES; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 78951487905     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.192849     Document Type: Article

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