The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 23, 2000, Pages 12463-12468

  Umhau, Stephan ^a   Pollegioni, Loredano ^b   Molla, Gianluca ^b   Diederichs, Kay ^a   Welte, Wolfram ^a   Pilone, Mirella S ^b   Ghisla, Sandro ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF INSUBRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; DEXTRO ALANINE; DEXTRO AMINO ACID OXIDASE; DEXTRO TRIFLUOROALANINE; FLAVOPROTEIN; FUNCTIONAL GROUP; LACTIC ACID; OXIDOREDUCTASE; PEROXIDE; QUERCETIN; UNCLASSIFIED DRUG;

CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME MECHANISM; ENZYME STRUCTURE; HYDROGENATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; YEAST;

EID: 0033741877     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.23.12463     Document Type: Article

References (35)

1. Krebs, H. A. (1935) Biochem. J. 29, 1620-1625.
2. Warburg, O. & Christian, W. (1938) W. Biochem. Z. 298, 150-155.
3. Curti, B., Ronchi, S. & Pilone Simonetta, M. (1992) in Chemistry and Biochemistry of Flavoenzymes, ed. Müller, F. (CRC, Boca Raton, FL), Vol. III, pp. 69-94.
4. Wolosker, H., Blackshaw, S. & Snyder, S. H. (1999) Proc. Natl. Acad. Sci. USA 96, 13409-13414.
5. Walsh, C. T., Schonbrunn, A. & Abeles, R. (1971) J. Biol. Chem. 248, 6855-6866.
6. Hersh, L. B. & Schuman-Jorns, M. (1975) J. Biol. Chem. 250, 8728-8734.
7. Mattevi, A., Vanoni, M. A., Todone, F., Rizzi, M., Teplyakov A., Coda, A., Bolognesi, M. & Curti, B. (1990) Proc. Natl. Acad. Sci. USA 93, 7496-7501.
8. Todone, F., Vanoni, M. A., Mozzarelli, A., Bolognesi, M., Coda, A., Curti, B. & Mattevi, A. (1997) Biochemistry 36, 5853-5860.
9. Mizutani, H., Miyahara, I., Hirotsu, K., Nishina, Y., Shiga, K., Setoyama, C. & Miura, R. (1996) J. Biochem. 120, 14-17.
10. Miura, R., Setoyama, C., Nishina, Y., Shiga, K., Miyutani, H., Miyuhara, I. & Hirotsu. K. (1997) J. Biochem. 122, 825-833.
11. Pollegioni, L., Blodig, W. & Ghisla, S. (1997) J. Biol. Chem. 272, 4924-4934.
12. Molla, G., Vegezzi, C., Pilone, M. S. & Pollegioni, L. (1998) Protein Expression Purif. 14, 289-294.
13. Kabsch, W. J. (1988) J. Appl. Crystallogr. A 50, 157-163.
14. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., et al. (1998) Acta Crystallogr. D 54, 905-921.
15. Sheldrick, G. M. & Schneider, T. R. (1997) in Methods in Enzymology, eds. Carter, C. W., Jr. & Sweet, R. M. (Academic, New York), Vol. 277, pp. 319-343.
16. Brünger, A. T. (1992) Nature (London) 355, 472-475.
17. Engh, R. A. & Huber, R. (1991) Acta Crystallogr. A 47, 392-400.
18. Pollegioni, L., Langkau, B., Tischer, W., Ghisla, S. & Pilone, M. S. (1993) J. Biol. Chem. 268, 13850-13857.
19. Harris, C. M., Molla, G., Pilone, M. S. & Pollegioni, L. (1999) J. Biol. Chem. 274, 36233-36240.
20. Porter, D. J. T. & Voet, D. (1978) Acta Crystallogr. B 34, 598-606.
21. Fletterick, R. J., Tsai, C. & Hughes, R. H. (1971) J. Phys. Chem. 75, 918-922.
22. Kratochvil, B., Ondracek, J., Krechl, J. & Hasek, J. (1987) Acta Crystallogr. C 43, 2182-2183.
23. Fitzpatrick, P. F. & Massey, V. (1982) J. Biol. Chem. 257, 9958-9962.
24. Pawelek, P., Cheah, J., Coulombe, R., Macheroux, P., Ghisla, S. & Vrielink, A. (2000) EMBO J. 19, 4204-4215.
25. Yagi, K., Ozawa, T., Naoi, M. & Kotaki, A. (1968) in Flavins and Flavoproteins, ed. Yagi, K. (Univ. of Tokyo Press, Tokyo), pp. 237-251.
26. Lederer, F. (1991) in Chemistry and Biochemistry of Flavoenzymes, ed. Müller, F. (CRC, Boca Raton, FL), Vol. II, pp. 153-242.
27. Xia, Z.-X., Shamala, N., Bethge, P. H., Lim, L. W., Bellamy, H. D., Xuong, N. H., Lederer, F. & Mathews, F. S. (1987) Proc. Natl. Acad. Sci. USA 84, 2629-2633.
28. Molla, G., Porrini, D., Joh, V., Motteran, L., Vegezzi, C., Campaner, S., Pilone, M. S. & Pollegioni, L. (2000) J. Biol. Chem. 275, 24715-24721.
29. Steinberg, K., Clausen, T., Lindqvist, Y. & Macheroux, P. (1995) Eur. J. Biochem. 228, 408-416.
30. Abad-Zapatero, C., Griffith J. P., Sussman, J. L. & Rossmann, M. G. (1987) J. Mol. Biol. 198, 445-467.
31. Massey, V., Ghisla, S., Ballou, D. P., Walsh, C. T., Cheung, Y. T. & Abeles, R. H. (1975) in Flavins and Flavoproteins, ed. Singer, T. S. (Elsevier, Amsterdam), pp. 199-212.
32. Ghisla, S. & Massey, V. (1989) Eur. J. Biochem. 1811, 1-17.
33. Kohen, A. & Klinman, J. P. (1999) Chem. Biol. 6, 191-198.
34. Mesecar, A. D., Stoddard, B. L. & Koshland, D. E., Jr. (1997) Science 277, 202-206.
35. Diederichs, K. & Karplus, A. (1997) Nat. Struct. Biol. 4, 269-275.