Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis

Clinical Cancer Research

Volumn 9, Issue 2, 2003, Pages 594-600

  Dolled Filhart, Marisa ^a   Camp, Robert L ^a   Kowalski, Diane P ^a   Smith, Bradley L ^b   Rimm, David L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CELL SIGNALING TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; STAT3 PROTEIN; TYROSINE;

ARTICLE; BREAST CANCER; CANCER SURVIVAL; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; BREAST NEOPLASMS; CELL NUCLEUS; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MULTIVARIATE ANALYSIS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STAT3 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS; TIME FACTORS; TRANS-ACTIVATORS;

EID: 0037316938     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Darnell, J. E., Jr., Kerr, I. M., and Stark, G. R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (Wash. DC), 264: 1415-1421, 1994.
2. Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., and Akira, S. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA, 94: 3801-3804, 1997.
3. Bromberg, J., and Darnell, J. E., Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene, 19: 2468-2473, 2000.
4. Guschin, D., Rogers, N., Briscoe, J., Witthuhn, B., Watling, D., Horn, F., Pellegrini, S., Yasukawa, K., Heinrich, P., Stark, G. R., et al. A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J., 14: 1421-1429, 1995.
5. Turkson, J., and Jove, R. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene, 19: 6613-6626, 2000.
6. Philp, J. A., Burdon, T. G., and Watson, C. J. Differential activation of STATs 3 and 5 during mammary gland development. FEBS Lett., 396: 77-80, 1996.
7. Chapman, R. S., Lourenco, P., Tonner, E., Flint, D., Selbert, S., Takeda, K., Akira, S., Clarke, A. R., and Watson, C. J. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Adv. Exp. Med. Biol., 480: 129-138, 2000.
8. Chapman, R. S., Lourenco, P. C., Tonner, E., Flint, D. J., Selbert, S., Takeda, K., Akira, S., Clarke, A. R., and Watson, C. J. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev., 13: 2604-2616, 1999.
9. Sartor, C. I., Dziubinski, M. L., Yu, C. L., Jove, R., and Ethier, S. P. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res., 57: 978-987, 1997.
10. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Fairclough, R., Parsons, S., Laudano, A., Gazit, A., Levitzki, A., Kraker, A., and Jove, R. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene, 20: 2499-2513, 2001.
11. Garcia, R., Yu, C. L., Hudnall, A., Catlett, R., Nelson, K. L., Smithgall, T., Fujita, D. J., Ethier, S. P., and Jove, R. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ., 8: 1267-1276, 1997.
12. Page, C., Huang, M., Jin, X., Cho, K., Lilja, J., Reynolds, R. K., and Lin, J. Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells. Int. J. Oncol., 17: 23-28, 2000.
13. Bromberg, J. Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res., 2: 86-90, 2000.
14. Watson, C. J., and Miller, W. R. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br. J. Cancer, 71: 840-844, 1995.
15. Perou, C. M., Jeffrey, S. S., van de Rijn, M., Rees, C. A., Eisen, M. B., Ross, D. T., Pergamenschikov, A., Williams, C. F., Zhu, S. X., Lee, J. C., Lashkari, D., Shalon, D., Brown, P. O., and Botstein, D. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc. Natl. Acad. Sci. USA, 96: 9212-9217, 1999.
16. Berclaz, G., Altermatt, H. J., Rohrbach, V., Siragusa, A., Dreher, E., and Smith, P. D. EGFR dependent expression of Stat3 (but not STAT1) in breast cancer. Int. J. Oncol., 19: 1155-1160, 2001.
17. Bartoli, M., Gu, X., Tsai, N. T., Venema, R. C., Brooks, S. E., Marrero, M. B., and Caldwell, R. B. Vascular endothelial growth factor activates STAT proteins in aortic endothelial cells. J. Biol. Chem., 275: 33189-33192, 2000.
18. Campbell, C. L., Jiang, Z., Savarese, D. M., and Savarese, T. M. Increased expression of the interleukin-11 receptor and evidence of Stat3 activation in prostate carcinoma. Am. J. Pathol., 158: 25-32, 2001.
19. Battifora, H. The multitumor (sausage) tissue block: novel method for immunohistochemical antibody testing. Lab. Investig., 55: 244-248, 1986.
20. Kononen, J., Bubendorf, L., Kallioniemi, A., Barlund, M., Schraml, P., Leighton, S., Torhorst, J., Mihatsch, M. J., Sauter, G., and Kallioniemi, O. P. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med., 4: 844-847, 1998.
21. Rimm, D., Camp, R., Charette, L., Costa, J., Olsen, D., and Reiss, M. Tissue microarray: a new technology for amplification of tissue resources. Cancer J., 7: 24-31, 2001.
22. Camp, R. L., Charette, L. A., and Rimm, D. L. Validation of tissue microarray technology in breast carcinoma. Lab. Investig., 80: 1943-1949, 2000.
23. Gillett, C. E., Springall, R. J., Barnes, D. M., and Hanby, A. M. Multiple tissue core arrays in histopathology research: a validation study. J. Pathol., 192: 549-553, 2000.
24. Torhorst, J., Bucher, C., Kononen, J., Haas, P., Zuber, M., Kochli, O. R., Mross, F., Dieterich, H., Moch, H., Mihatsch, M., Kallioniemi, O. P., and Sauter, G. Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am. J. Pathol., 159: 2249-2256, 2001.
25. Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., and Darnell, J. E., Jr. Stat3 activation is required for cellular transformation by v-src. Mol. Cell. Biol., 18: 2553-2558, 1998.
26. Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., and Jove, R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol., 18: 2545-2552, 1998.
27. Huang, M., Page, C., Reynolds, R. K., and Lin, J. Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol. Oncol., 79: 67-73, 2000.
28. Xia, Z., Sait, S. N., Baer, M. R., Barcos, M., Donohue, K. A., Lawrence, D., Ford, L. A., Block, A. M., Baumann, H., and Wetzler, M. Truncated STAT proteins are prevalent at relapse of acute myeloid leukemia. Leuk. Res., 25: 473-482, 2001.
29. Dolled-Filhart, M., and Rimm, D. L. Tissue microarray technology: A new standard for molecular evaluation of tissue?, Principals and Practice of Oncology Updates. 16: 1-11, 2002.