AKT1 polymorphisms are associated with risk for metabolic syndrome

Human Genetics

Volumn 129, Issue 2, 2011, Pages 129-139

  Devaney, Joseph M ^a   Gordish Dressman, Heather ^a   Harmon, Brennan T ^a   Bradbury, Margaret K ^a   Devaney, Stephanie A ^a   Harris, Tamara B ^b   Thompson, Paul D ^c   Clarkson, Priscilla M ^d   Price, Thomas B ^c,e   Angelopoulos, Theodore J ^f   Gordon, Paul M ^g   Moyna, Niall M ^h   Pescatello, Linda S ⁱ   Visich, Paul S ^j   Zoeller, Robert F ^k   Seip, Richard L ^c   Seo, Jinwook ^a   Kim, Bo Hyoung ^l   Tosi, Laura L ^m   Garcia, Melissa ^b   Li, Rongling ⁿ   Zmuda, Joseph M ^o   Delmonico, Matthew J ^p   Lindsay, Robert S ^q   Howard, Barbara V ^r   Kraus, William E ^s   Hoffman, Eric P ^a   more..

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c HARTFORD HOSPITAL   (United States)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CENTRAL FLORIDA   (United States)

^g UNIVERSITY OF MICHIGAN   (United States)

^h DUBLIN CITY UNIVERSITY   (Ireland)

ⁱ UNIVERSITY OF CONNECTICUT   (United States)

^j CENTRAL MICHIGAN UNIVERSITY   (United States)

^k FLORIDA ATLANTIC UNIVERSITY   (United States)

^l INFINITT Healthcare   (South Korea)

^m CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

ⁿ UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^o UNIVERSITY OF PITTSBURGH   (United States)

^p UNIVERSITY OF RHODE ISLAND   (United States)

^q UNIVERSITY OF GLASGOW   (United Kingdom)

^r MEDSTAR RESEARCH INSTITUTE   (United States)

^s DUKE UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; PROTEIN KINASE B;

ADULT; AGED; AGING; AMERICAN INDIAN; ARTICLE; BODY COMPOSITION; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; EUROPEAN AMERICAN; EXON; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HOMOZYGOTE; HUMAN; INCIDENCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; AGING; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-AKT; YOUNG ADULT;

EID: 78951471415     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-010-0910-8     Document Type: Article

References (40)

1. KG Alberti PZ Zimmet 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 539 553 1:STN:280:DyaK1czkvFCrsA%3D%3D 9686693 10.1002/(SICI)1096-9136(199807)15: 7<539::AID-DIA668>3.0.CO;2-S
2. KG Alberti P Zimmet J Shaw 2006 Metabolic syndrome-a new world-wide definition. A consensus statement from the International Diabetes Federation Diabet Med 23 469 480 1:STN:280:DC%2BD283lslGgsQ%3D%3D 16681555 10.1111/j.1464-5491.2006.01858.x
3. E Bernal-Mizrachi W Wen S Stahlhut CM Welling MA Permutt 2001 Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia J Clin Investig 108 1631 1638 1:CAS:528:DC%2BD3MXovVCgs7c%3D 11733558
4. E Bernal-Mizrachi S Fatrai JD Johnson M Ohsugi K Otani Z Han KS Polonsky MA Permutt 2004 Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells J Clin Investig 114 928 936 1:CAS:528:DC%2BD2cXot12gtrY%3D 15467831
5. N Bouatia-Naji G Rocheleau L Van Lommel K Lemaire F Schuit C Cavalcanti-Proenca M Marchand AL Hartikainen U Sovio F De Graeve J Rung M Vaxillaire J Tichet M Marre B Balkau J Weill P Elliott MR Jarvelin D Meyre C Polychronakos C Dina R Sladek P Froguel 2008 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels Science 320 1085 1088 1:CAS:528:DC%2BD1cXmtVKnsLc%3D 18451265 10.1126/science.1156849
6. J Dupuis C Langenberg I Prokopenko R Saxena N Soranzo AU Jackson E Wheeler NL Glazer N Bouatia-Naji AL Gloyn CM Lindgren R Magi AP Morris J Randall T Johnson P Elliott D Rybin G Thorleifsson V Steinthorsdottir P Henneman H Grallert A Dehghan JJ Hottenga CS Franklin P Navarro K Song A Goel JR Perry JM Egan T Lajunen N Grarup T Sparso A Doney BF Voight HM Stringham M Li S Kanoni P Shrader C Cavalcanti-Proenca M Kumari L Qi NJ Timpson C Gieger C Zabena G Rocheleau E Ingelsson P An J O'Connell J Luan A Elliott SA McCarroll F Payne RM Roccasecca F Pattou P Sethupathy K Ardlie Y Ariyurek B Balkau P Barter JP Beilby Y Ben-Shlomo R Benediktsson AJ Bennett S Bergmann M Bochud E Boerwinkle A Bonnefond LL Bonnycastle K Borch-Johnsen Y Bottcher E Brunner SJ Bumpstead G Charpentier YD Chen P Chines R Clarke LJ Coin MN Cooper M Cornelis G Crawford L Crisponi IN Day EJ de Geus J Delplanque C Dina MR Erdos AC Fedson A Fischer-Rosinsky NG Forouhi CS Fox R Frants MG Franzosi P Galan MO Goodarzi J Graessler CJ Groves S Grundy R Gwilliam U Gyllensten S Hadjadj, et al. 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105 116 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 20081858 10.1038/ng.520
7. L Elghazi N Balcazar E Bernal-Mizrachi 2006 Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function Int J Biochem Cell Biol 38 157 163 1:CAS:528:DC%2BD2MXht1aqu7jP 16213777 10.1016/j.biocel. 2006.01.005
8. EU Frevert C Bjorbaek CL Venable SR Keller BB Kahn 1998 Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes J Biol Chem 273 25480 25487 1:CAS:528:DyaK1cXmsVGlsrk%3D 9738018 10.1074/jbc.273.39.25480
9. SM Grundy HB Brewer Jr JI Cleeman SC Smith Jr C Lenfant 2004 Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition Circulation 109 433 438 14744958 10.1161/01.CIR.0000111245.75752.C6
10. E Hajduch DR Alessi BA Hemmings HS Hundal 1998 Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells Diabetes 47 1006 1013 1:CAS:528:DyaK1cXkt1ajtro%3D 9648821 10.2337/diabetes.47.7.1006
11. SL Harris G Gil H Robins W Hu K Hirshfield E Bond G Bond AJ Levine 2005 Detection of functional single-nucleotide polymorphisms that affect apoptosis Proc Natl Acad Sci USA 102 16297 16302 1:CAS:528:DC%2BD2MXht1CgurrP 16260726 10.1073/pnas.0508390102
12. AC Jones J Austin N Hansen B Hoogendoorn PJ Oefner JP Cheadle MC O'Donovan 1999 Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis Clin Chem 45 1133 1140 1:CAS:528:DyaK1MXltFGnu7g%3D 10430776
13. ET Lee TK Welty R Fabsitz LD Cowan NA Le AJ Oopik AJ Cucchiara PJ Savage BV Howard 1990 The Strong Heart Study. A study of cardiovascular disease in American Indians: design and methods Am J Epidemiol 132 1141 1155 1:STN:280:DyaK3M%2Fot1Oruw%3D%3D 2260546
14. V Lyssenko CL Nagorny MR Erdos N Wierup A Jonsson P Spegel M Bugliani R Saxena M Fex N Pulizzi B Isomaa T Tuomi P Nilsson J Kuusisto J Tuomilehto M Boehnke D Altshuler F Sundler JG Eriksson AU Jackson M Laakso P Marchetti RM Watanabe H Mulder L Groop 2009 Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion Nat Genet 41 82 88 1:CAS:528:DC%2BD1cXhsVKlt77J 19060908 10.1038/ng.288
15. MF Moffatt M Kabesch L Liang AL Dixon D Strachan S Heath M Depner A von Berg A Bufe E Rietschel A Heinzmann B Simma T Frischer SA Willis-Owen KC Wong T Illig C Vogelberg SK Weiland E von Mutius GR Abecasis M Farrall IG Gut GM Lathrop WO Cookson 2007 Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma Nature 448 470 473 1:CAS:528: DC%2BD2sXotFajurY%3D 17611496 10.1038/nature06014
16. J Mogensen A Bahl T Kubo N Elanko R Taylor WJ McKenna 2003 Comparison of fluorescent SSCP and denaturing HPLC analysis with direct sequencing for mutation screening in hypertrophic cardiomyopathy J Med Genet 40 e59 1:STN:280:DC%2BD3s3isVChtg%3D%3D 12746413 10.1136/jmg.40.5.e59
17. T Murray TH Beaty RA Mathias N Rafaels AV Grant MU Faruque HR Watson I Ruczinski GM Dunston KC Barnes 2010 African and non-African admixture components in African Americans and an African Caribbean population Genet Epidemiol 34 6 561 568 20717976 10.1002/gepi.20512
18. GA Nader 2005 Molecular determinants of skeletal muscle mass: getting the "AKT" together Int J Biochem Cell Biol 37 1985 1996 1:CAS:528:DC%2BD2MXpsVWms74%3D 16125108 10.1016/j.biocel.2005.02.026
19. NCEP 2001 Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA 285 2486 2497 10.1001/jama.285.19.2486
20. I Prokopenko C Langenberg JC Florez R Saxena N Soranzo G Thorleifsson RJ Loos AK Manning AU Jackson Y Aulchenko SC Potter MR Erdos S Sanna JJ Hottenga E Wheeler M Kaakinen V Lyssenko WM Chen K Ahmadi JS Beckmann RN Bergman M Bochud LL Bonnycastle TA Buchanan A Cao A Cervino L Coin FS Collins L Crisponi EJ de Geus A Dehghan P Deloukas AS Doney P Elliott N Freimer V Gateva C Herder A Hofman TE Hughes S Hunt T Illig M Inouye B Isomaa T Johnson A Kong M Krestyaninova J Kuusisto M Laakso N Lim U Lindblad CM Lindgren OT McCann KL Mohlke AD Morris S Naitza M Orru CN Palmer A Pouta J Randall W Rathmann J Saramies P Scheet LJ Scott A Scuteri S Sharp E Sijbrands JH Smit K Song V Steinthorsdottir HM Stringham T Tuomi J Tuomilehto AG Uitterlinden BF Voight D Waterworth HE Wichmann G Willemsen JC Witteman X Yuan JH Zhao E Zeggini D Schlessinger M Sandhu DI Boomsma M Uda TD Spector BW Penninx D Altshuler P Vollenweider MR Jarvelin E Lakatta G Waeber CS Fox L Peltonen LC Groop V Mooser LA Cupples U Thorsteinsdottir M Boehnke I Barroso, et al. 2009 Variants in MTNR1B influence fasting glucose levels Nat Genet 41 77 81 1:CAS:528: DC%2BD1cXhsVKlt7vM 19060907 10.1038/ng.290
21. TK Rice NJ Schork DC Rao 2008 Methods for handling multiple testing Adv Genet 60 293 308 18358325 10.1016/S0065-2660(07)00412-9
22. SS Rich MO Goodarzi ND Palmer CD Langefeld J Ziegler SM Haffner M Bryer-Ash JM Norris KD Taylor T Haritunians JI Rotter YD Chen LE Wagenknecht DW Bowden RN Bergman 2009 A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS) Diabetologia 52 1326 1333 1:CAS:528:DC%2BD1MXms1yhsLw%3D 19430760 10.1007/s00125-009-1373-0
23. J Rung S Cauchi A Albrechtsen L Shen G Rocheleau C Cavalcanti-Proenca F Bacot B Balkau A Belisle K Borch-Johnsen G Charpentier C Dina E Durand P Elliott S Hadjadj MR Jarvelin J Laitinen T Lauritzen M Marre A Mazur D Meyre A Montpetit C Pisinger B Posner P Poulsen A Pouta M Prentki R Ribel-Madsen A Ruokonen A Sandbaek D Serre J Tichet M Vaxillaire JF Wojtaszewski A Vaag T Hansen C Polychronakos O Pedersen P Froguel R Sladek 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nat Genet 41 1110 1115 1:CAS:528:DC%2BD1MXhtV2gsb%2FL 19734900 10.1038/ng.443
24. R Saxena BF Voight V Lyssenko NP Burtt PI de Bakker H Chen JJ Roix S Kathiresan JN Hirschhorn MJ Daly TE Hughes L Groop D Altshuler P Almgren JC Florez J Meyer K Ardlie K Bengtsson Bostrom B Isomaa G Lettre U Lindblad HN Lyon O Melander C Newton-Cheh P Nilsson M Orho-Melander L Rastam EK Speliotes MR Taskinen T Tuomi C Guiducci A Berglund J Carlson L Gianniny R Hackett L Hall J Holmkvist E Laurila M Sjogren M Sterner A Surti M Svensson R Tewhey B Blumenstiel M Parkin M Defelice R Barry W Brodeur J Camarata N Chia M Fava J Gibbons B Handsaker C Healy K Nguyen C Gates C Sougnez D Gage M Nizzari SB Gabriel GW Chirn Q Ma H Parikh D Richardson D Ricke S Purcell 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 1:CAS:528:DC%2BD2sXmtVyitrk%3D 17463246 10.1126/science.1142358
25. R Saxena MF Hivert C Langenberg T Tanaka JS Pankow P Vollenweider V Lyssenko N Bouatia-Naji J Dupuis AU Jackson WH Kao M Li NL Glazer AK Manning J Luan HM Stringham I Prokopenko T Johnson N Grarup TW Boesgaard C Lecoeur P Shrader J O'Connell E Ingelsson DJ Couper K Rice K Song CH Andreasen C Dina A Kottgen O Le Bacquer F Pattou J Taneera V Steinthorsdottir D Rybin K Ardlie M Sampson L Qi M van Hoek MN Weedon YS Aulchenko BF Voight H Grallert B Balkau RN Bergman SJ Bielinski A Bonnefond LL Bonnycastle K Borch-Johnsen Y Bottcher E Brunner TA Buchanan SJ Bumpstead C Cavalcanti-Proenca G Charpentier YD Chen PS Chines FS Collins M Cornelis G JC J Delplanque A Doney JM Egan MR Erdos M Firmann NG Forouhi CS Fox MO Goodarzi J Graessler A Hingorani B Isomaa T Jorgensen M Kivimaki P Kovacs K Krohn M Kumari T Lauritzen C Levy-Marchal V Mayor JB McAteer D Meyre BD Mitchell KL Mohlke MA Morken N Narisu CN Palmer R Pakyz L Pascoe F Payne D Pearson W Rathmann A Sandbaek AA Sayer LJ Scott SJ Sharp E Sijbrands A Singleton DS Siscovick NL Smith T Sparso, et al. 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 42 142 148 1:CAS:528:DC%2BC3cXntVCksw%3D%3D 20081857 10.1038/ng.521
26. LJ Scott KL Mohlke LL Bonnycastle CJ Willer Y Li WL Duren MR Erdos HM Stringham PS Chines AU Jackson L Prokunina-Olsson CJ Ding AJ Swift N Narisu T Hu R Pruim R Xiao XY Li KN Conneely NL Riebow AG Sprau M Tong PP White KN Hetrick MW Barnhart CW Bark JL Goldstein L Watkins F Xiang J Saramies TA Buchanan RM Watanabe TT Valle L Kinnunen GR Abecasis EW Pugh KF Doheny RN Bergman J Tuomilehto FS Collins M Boehnke 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345 1:CAS:528:DC%2BD2sXmtVyitrY%3D 17463248 10.1126/science.1142382
27. CA Slentz JA Houmard JL Johnson LA Bateman CJ Tanner JS McCartney BD Duscha WE Kraus 2007 Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount J Appl Physiol 103 432 442 1:CAS:528:DC%2BD2sXhtVShs77N 17395756 10.1152/japplphysiol.01314.2006
28. M Stephens NJ Smith P Donnelly 2001 A new statistical method for haplotype reconstruction from population data Am J Hum Genet 68 978 989 1:STN:280:DC%2BD3M3kslWgsA%3D%3D 11254454 10.1086/319501
29. MP Stern 1998 Invited commentary: cardiovascular mortality in American Indians: paradox explained? Am J Epidemiol 147 1009 1010 1:STN:280: DyaK1c3otFensA%3D%3D 9620043
30. XJ Sun P Rothenberg CR Kahn JM Backer E Araki PA Wilden DA Cahill BJ Goldstein MF White 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature 352 73 77 1:CAS:528:DyaK38Xit1ygur8%3D 1648180 10.1038/352073a0
31. XJ Sun LM Wang Y Zhang L Yenush MG Myers Jr E Glasheen WS Lane JH Pierce MF White 1995 Role of IRS-2 in insulin and cytokine signalling Nature 377 173 177 1:CAS:528:DyaK2MXotVOhtLc%3D 7675087 10.1038/377173a0
32. TM Teslovich K Musunuru AV Smith AC Edmondson IM Stylianou M Koseki JP Pirruccello S Ripatti DI Chasman CJ Willer CT Johansen SW Fouchier A Isaacs GM Peloso M Barbalic SL Ricketts JC Bis YS Aulchenko G Thorleifsson MF Feitosa J Chambers M Orho-Melander O Melander T Johnson X Li X Guo M Li Y Shin Cho M Jin Go Y Jin Kim JY Lee T Park K Kim X Sim R Twee-Hee Ong DC Croteau-Chonka LA Lange JD Smith K Song J Hua Zhao X Yuan J Luan C Lamina A Ziegler W Zhang RY Zee AF Wright JC Witteman JF Wilson G Willemsen HE Wichmann JB Whitfield DM Waterworth NJ Wareham G Waeber P Vollenweider BF Voight V Vitart AG Uitterlinden M Uda J Tuomilehto JR Thompson T Tanaka I Surakka HM Stringham TD Spector N Soranzo JH Smit J Sinisalo K Silander EJ Sijbrands A Scuteri J Scott D Schlessinger S Sanna V Salomaa J Saharinen C Sabatti A Ruokonen I Rudan LM Rose R Roberts M Rieder BM Psaty PP Pramstaller I Pichler M Perola BW Penninx NL Pedersen C Pattaro AN Parker G Pare BA Oostra CJ O'Donnell MS Nieminen DA Nickerson GW Montgomery T Meitinger R McPherson MI McCarthy, et al. 2010 Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 707 713 1:CAS:528:DC%2BC3cXhtVSmurfI 20686565 10.1038/nature09270
33. PD Thompson N Moyna R Seip T Price P Clarkson T Angelopoulos P Gordon L Pescatello P Visich R Zoeller JM Devaney H Gordish S Bilbie EP Hoffman 2004 Functional polymorphisms associated with human muscle size and strength Med Sci Sports Exerc 36 1132 1139 15235316 10.1249/01.MSS.0000132274.26612.23
34. RL Tuttle NS Gill W Pugh JP Lee B Koeberlein EE Furth KS Polonsky A Naji MJ Birnbaum 2001 Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha Nat Med 7 1133 1137 1:CAS:528:DC%2BD3MXns12kur4%3D 11590437 10.1038/nm1001-1133
35. J Uthurralt H Gordish-Dressman M Bradbury C Tesi-Rocha J Devaney B Harmon EK Reeves C Brandoli BC Hansen RL Seip PD Thompson TB Price TJ Angelopoulos PM Clarkson NM Moyna LS Pescatello PS Visich RF Zoeller PM Gordon EP Hoffman 2007 PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males BMC Med Genet 8 55 17705849 10.1186/1471-2350-8-55
36. M Visser T Fuerst T Lang L Salamone TB Harris 1999 Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study-Dual-Energy X-ray Absorptiometry and Body Composition Working Group J Appl Physiol 87 1513 1520 1:STN:280:DyaK1MvkslOmsg%3D%3D 10517786
37. Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678 10.1038/nature05911
38. J Zdychova R Komers 2005 Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications Physiol Res 54 1 16 1:CAS:528:DC%2BD2MXjtVGgs78%3D 15717836
39. E Zeggini LJ Scott R Saxena BF Voight JL Marchini T Hu PI de Bakker GR Abecasis P Almgren G Andersen K Ardlie KB Bostrom RN Bergman LL Bonnycastle K Borch-Johnsen NP Burtt H Chen PS Chines MJ Daly P Deodhar CJ Ding AS Doney WL Duren KS Elliott MR Erdos TM Frayling RM Freathy L Gianniny H Grallert N Grarup CJ Groves C Guiducci T Hansen C Herder GA Hitman TE Hughes B Isomaa AU Jackson T Jorgensen A Kong K Kubalanza FG Kuruvilla J Kuusisto C Langenberg H Lango T Lauritzen Y Li CM Lindgren V Lyssenko AF Marvelle C Meisinger K Midthjell KL Mohlke MA Morken AD Morris N Narisu P Nilsson KR Owen CN Palmer F Payne JR Perry E Pettersen C Platou I Prokopenko L Qi L Qin NW Rayner M Rees JJ Roix A Sandbaek B Shields M Sjogren V Steinthorsdottir HM Stringham AJ Swift G Thorleifsson U Thorsteinsdottir NJ Timpson T Tuomi J Tuomilehto M Walker RM Watanabe MN Weedon CJ Willer T Illig K Hveem FB Hu M Laakso K Stefansson O Pedersen NJ Wareham I Barroso AT Hattersley FS Collins L Groop MI McCarthy M Boehnke D Altshuler 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645 1:CAS:528:DC%2BD1cXltFylurY%3D 18372903 10.1038/ng.120
40. RF Zoeller ED Ryan H Gordish-Dressman TB Price RL Seip TJ Angelopoulos NM Moyna PM Gordon PD Thompson EP Hoffman 2007 Allometric scaling of biceps strength before and after resistance training in men Med Sci Sports Exerc 39 1013 1019 17545893 10.1249/mss.0b013e3180423aad