Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7344-7352

  Shah, Jamshed H ^a   Agoston, Gregory E ^a   Suwandi, Lita ^a   Hunsucker, Kimberly ^a   Pribluda, Victor ^a   Zhan, Xiaoguo H ^a   Swartz, Glenn M ^a   LaVallee, Theresa M ^a   Treston, Anthony M ^a  

^a ENTREMED INC   (United States)

Author keywords

2 Methoxyestradiol analogs; Antiangiogenic; Antiproliferative; Structure activity relationships

Indexed keywords

2 METHOXYESTRADIOL; ESTRONE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER MICROSOME; NONHUMAN; RAT;

ANIMALS; CELL LINE; CELL PROLIFERATION; ESTRADIOL; ESTRONE; HUMANS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 71749116055     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.038     Document Type: Article

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