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Volumn 19, Issue 21, 2009, Pages 6241-6244

Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol

Author keywords

2 Methoxyestradiol analogs; Antiproliferative; Antitumor

Indexed keywords

17 DEOXYESTRADIOL; 17 ETHYLENE ESTRADIOL; 17 METHYLENE ESTRADIOL; 17 OLEFIN ESTRADIOL; 17 OXO ESTRADIOL; 2 METHOXYESTRADIOL; 2 METHOXYESTRONE; 3 METHYLCARBAMIC ACID; ACETAMIDE DERIVATIVE; ALKENE DERIVATIVE; AMIDE; AMINE; AMINONITRILE; CARBAMIC ACID DERIVATIVE; ENMD 1198; ESTRADIOL; ESTRADIOL DERIVATIVE; ESTROGEN DERIVATIVE; FORMAMIDE; NITRILE; UNCLASSIFIED DRUG;

EID: 71049183916     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.020     Document Type: Article
Times cited : (13)

References (21)
  • 17
    • 0006202778 scopus 로고
    • Rajohn N. (Ed), John Wiley & Sons, NY
    • Kurzer F. In: Rajohn N. (Ed). Organic Synthesis Vol. IV (1963), John Wiley & Sons, NY 49-54
    • (1963) Organic Synthesis , vol.IV , pp. 49-54
    • Kurzer, F.1
  • 20
    • 71749090469 scopus 로고    scopus 로고
    • note
    • Six rats were implanted with jugular vein canulae. The compounds (3-5/cassette) were administered to three rats intravenously and three rats orally. Blood was taken at ten timepoints for intravenous and eight time points for the oral route. Compounds were extracted by plasma protein precipitation and analyzed by LC-MSMS. PK parameters were calculated using WinNonlin (Pharsight Inc.).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.