Cytotoxicity and cytoprotective activity in naphthalenediols depends on their tendency to form naphthoquinones

Free Radical Biology and Medicine

Volumn 39, Issue 10, 2005, Pages 1368-1377

  Flueraru, Mihaela ^a   Chichirau, Alexandru ^a   Chepelev, Leonid L ^a   Willmore, William G ^a   Durst, Tony ^b   Charron, Martin ^b   Barclay, L R C ^c   Wright, James S ^a  

^a CARLETON UNIVERSITY   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c MOUNT ALLISON UNIVERSITY   (Canada)

Author keywords

Antioxidant activity; Bond dissociation enthalpy; Free radicals; Naphthalenediol (naphthohydroquinone) cytotoxicity; PC12 adrenal pheochromocytoma cells; Quinone redox cycling

Indexed keywords

1,2 NAPHTHALENEDIOL; 1,4 DIPROPYL 2,3 NAPHTHALENEDIOL; 1,4 NAPHTHALENEDIOL; 1,4 NAPHTHOQUINONE DERIVATIVE; 1,8 NAPHTHALENEDIOL; 2,3 NAPHTHALENEDIOL; EPIGALLOCATECHIN GALLATE; NAPHTHALENE DERIVATIVE; PEROXY RADICAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENTHALPY; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; ANTIOXIDANTS; CATECHIN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; HEAT; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NAPHTHOLS; NAPHTHOQUINONES; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUINONES; RATS; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

ANIMALIA;

EID: 27544509498     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.06.020     Document Type: Article

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