1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 983-988

  Anandan, Sampath Kumar ^a   Webb, Heather Kay ^a   Chen, Dawn ^a   Wang, Yi Xin ^a   Aavula, Basker R ^a   Cases, Sylvaine ^a   Cheng, Ying ^a   Do, Zung N ^a   Mehra, Upasana ^a   Tran, Vinh ^a   Vincelette, Jon ^a   Waszczuk, Joanna ^a   White, Kathy ^a   Wong, Kenneth R ^a   Zhang, Le Ning ^a   Jones, Paul D ^b   Hammock, Bruce D ^b   Patel, Dinesh V ^a   Whitcomb, Randall ^a   MacIntyre, D Euan ^a   Sabry, James ^a   Gless, Richard ^a   more..

^a Arete Therapeutics Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AngII hypertension model; AR9281; Diabetes; DIO model; Efficacy; sEH inhibitor

Indexed keywords

1 (1 ACETYLPIPERIDIN 4 YL) 3 ADAMANTAN 1 YLUREA; ADAMANTANE DERIVATIVE; AR 9281; ENZYME INHIBITOR; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE INHIBITOR; GLUCOSE; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HYPERTENSION; IMPAIRED GLUCOSE TOLERANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADAMANTANE; ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD GLUCOSE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HYPERTENSION; INSULIN RESISTANCE; MICE; OBESITY; RATS; UREA;

RATTUS; RODENTIA;

EID: 78751648188     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.042     Document Type: Article

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