Rapid synthesis of an array of trisubstituted urea-based soluble epoxide hydrolase inhibitors facilitated by a novel solid-phase method

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3703-3707

  Kowalski, Jennifer A ^a   Swinamer, Alan D ^a   Muegge, Ingo ^a   Eldrup, Anne B ^a   Kukulka, Alison ^a   Cywin, Charles L ^a   De Lombaert, Stéphane ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Parallel array; Solid phase synthesis; Soluble epoxide hydrolase

Indexed keywords

EPOXIDE HYDROLASE; HYDROLASE INHIBITOR; UREA; UREA DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; PHARMACOPHORE; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HUMANS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 77954219382     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.078     Document Type: Article

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