Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5314-5320

  Shen, Hong C ^a   Ding, Fa Xiang ^a   Deng, Qiaolin ^a   Xu, Suoyu ^a   Chen, Hsuan shen ^a   Tong, Xinchun ^a   Tong, Vincent ^a   Zhang, Xiaoping ^a   Chen, Yuli ^a   Zhou, Gaochao ^a   Pai, Lee Yuh ^a   Alonso Galicia, Magdalena ^a   Zhang, Bei ^a   Roy, Sophie ^a   Tata, James R ^a   Berger, Joel P ^a   Colletti, Steven L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Inhibitors; sEH; Soluble epoxide hydrolase; Ureas

Indexed keywords

ENZYME INHIBITOR; EPOXIDE HYDROLASE; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HUMAN; HYPERTENSION; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; BLOOD PRESSURE; EPOXIDE HYDROLASES; HUMANS; HYPERTENSION; MODELS, MOLECULAR; PIPERIDINES; PROTEIN BINDING; RATS; RATS, INBRED SHR; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

RATTUS;

EID: 68949086366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.138     Document Type: Article

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