A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5716-5721

  Shen, Hong C ^a   Ding, Fa Xiang ^a   Deng, Qiaolin ^a   Xu, Suoyu ^a   Tong, Xinchun ^a   Zhang, Xiaoping ^a   Chen, Yuli ^a   Zhou, Gaochao ^a   Pai, Lee Yuh ^a   Alonso Galicia, Magdalena ^a   Roy, Sophie ^a   Zhang, Bei ^a   Tata, James R ^a   Berger, Joel P ^a   Colletti, Steven L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amide mimics; Aminoheterocycles; Inhibitors; sEH; Soluble epoxide hydrolase

Indexed keywords

AMIDE; BENZISOTHIAZOLE; BENZISOXAZOLE; BENZOTHIAZOLE; BENZOXAZOLE DERIVATIVE; HETEROCYCLIC AMINE; INDAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; QUINOXALINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDES; ANILINE COMPOUNDS; ANIMALS; BINDING SITES; COMPUTER SIMULATION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; ISOXAZOLES; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949091361     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.006     Document Type: Article

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