-
1
-
-
66349109660
-
Arachidonic acid cytochrome P450 epoxygenase pathway
-
Spector, A.A. Arachidonic acid cytochrome P450 epoxygenase pathway. J. Lipid Res. 2009, 50, S52–S56.
-
(2009)
J. Lipid Res
, vol.50
, pp. S52-S56
-
-
Spector, A.A.1
-
2
-
-
14644429730
-
Epoxide hydrolases: their roles and interactions with lipid metabolism
-
Newman, J.W.; Morisseau, C.; Hammock, B.D. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog. Lipid Res. 2005, 44, 1–51.
-
(2005)
Prog. Lipid Res
, vol.44
, pp. 1-51
-
-
Newman, J.W.1
Morisseau, C.2
Hammock, B.D.3
-
3
-
-
66649116553
-
Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery
-
Marino, J.P., Jr. Soluble epoxide hydrolase, a target with multiple opportunities for cardiovascular drug discovery. Curr. Top. Med. Chem. 2009, 9, 452–463.
-
(2009)
Curr. Top. Med. Chem
, vol.9
, pp. 452-463
-
-
Marino, J.P.1
-
4
-
-
34247867952
-
Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors
-
Imig, J.D. Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors. Cardiovasc. Drug Rev. 2006, 24, 169–188.
-
(2006)
Cardiovasc. Drug Rev
, vol.24
, pp. 169-188
-
-
Imig, J.D.1
-
5
-
-
34147160073
-
Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase
-
Loch, D.; Hoey, A.; Morisseau, C.; Hammock, B.D.; Brown, L. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem. Biophys. 2007, 47, 87–98.
-
(2007)
Cell Biochem. Biophys
, vol.47
, pp. 87-98
-
-
Loch, D.1
Hoey, A.2
Morisseau, C.3
Hammock, B.D.4
Brown, L.5
-
6
-
-
15744382006
-
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension
-
Jung, O.; Brandes, R.P.; Kim, I.H.; Schweda, F.; Schmidt, R.; Hammock, B.D.; Busse, R.; Fleming, I. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension 2005, 45, 759–765.
-
(2005)
Hypertension
, vol.45
, pp. 759-765
-
-
Jung, O.1
Brandes, R.P.2
Kim, I.H.3
Schweda, F.4
Schmidt, R.5
Hammock, B.D.6
Busse, R.7
Fleming, I.8
-
7
-
-
11144356945
-
Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
-
Zhao, X.; Yamamoto, T.; Newman, J.W.; Kim, I.H.; Watanabe, T.; Hammock, B.D.; Stewart, J.; Pollock, J.S.; Pollock, D.M.; Imig, J.D. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J. Am. Soc. Nephrol. 2004, 15, 1244–1253.
-
(2004)
J. Am. Soc. Nephrol
, vol.15
, pp. 1244-1253
-
-
Zhao, X.1
Yamamoto, T.2
Newman, J.W.3
Kim, I.H.4
Watanabe, T.5
Hammock, B.D.6
Stewart, J.7
Pollock, J.S.8
Pollock, D.M.9
Imig, J.D.10
-
8
-
-
42149190687
-
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats
-
Ghosh, S.; Chiang, P.C.; Wahlstrom, J.L.; Fujiwara, H.; Selbo, J.G.; Roberds, S.L. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic Clin. Pharmacol. Toxicol. 2008, 102, 453–458.
-
(2008)
Basic Clin. Pharmacol. Toxicol
, vol.102
, pp. 453-458
-
-
Ghosh, S.1
Chiang, P.C.2
Wahlstrom, J.L.3
Fujiwara, H.4
Selbo, J.G.5
Roberds, S.L.6
-
9
-
-
33644654633
-
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension
-
Imig, J.D.; Zhao, X.; Zaharis, C.Z.; Olearczyk, J.J.; Pollock, D.M.; Newman, J.W.; Kim, I.H.; Watanabe, T.; Hammock, B.D. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 2005, 46, 975–981.
-
(2005)
Hypertension
, vol.46
, pp. 975-981
-
-
Imig, J.D.1
Zhao, X.2
Zaharis, C.Z.3
Olearczyk, J.J.4
Pollock, D.M.5
Newman, J.W.6
Kim, I.H.7
Watanabe, T.8
Hammock, B.D.9
-
10
-
-
22244443733
-
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
-
Schmelzer, K.R.; Kubala, L.; Newman, J.W.; Kim, I.H.; Eiserich, J.P.; Hammock, B.D. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc. Natl. Acad. Sci. USA 2005, 102, 9772–9777.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 9772-9777
-
-
Schmelzer, K.R.1
Kubala, L.2
Newman, J.W.3
Kim, I.H.4
Eiserich, J.P.5
Hammock, B.D.6
-
11
-
-
33750529521
-
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain
-
Inceoglu, B.; Jinks, S.L.; Schmelzer, K.R.; Waite, T.; Kim, I.H.; Hammock, B.D. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci. 2006, 79, 2311–2319.
-
(2006)
Life Sci
, vol.79
, pp. 2311-2319
-
-
Inceoglu, B.1
Jinks, S.L.2
Schmelzer, K.R.3
Waite, T.4
Kim, I.H.5
Hammock, B.D.6
-
12
-
-
60549106716
-
Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats
-
Olearczyk, J.J.; Quigley, J.E.; Mitchell, B.C.; Yamamoto, T.; Kim, I.H.; Newman, J.W.; Luria, A.; Hammock, B.D.; Imig, J.D. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clin. Sci. (Lond) 2009, 116, 61–70.
-
(2009)
Clin. Sci. (Lond)
, vol.116
, pp. 61-70
-
-
Olearczyk, J.J.1
Quigley, J.E.2
Mitchell, B.C.3
Yamamoto, T.4
Kim, I.H.5
Newman, J.W.6
Luria, A.7
Hammock, B.D.8
Imig, J.D.9
-
13
-
-
67049119782
-
Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection
-
Simpkins, A.N.; Rudic, R.D.; Schreihofer, D.A.; Roy, S.; Manhiani, M.; Tsai, H.J.; Hammock, B.D.; Imig, J.D. Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. Am. J. Pathol. 2009, 174, 2086–2095.
-
(2009)
Am. J. Pathol
, vol.174
, pp. 2086-2095
-
-
Simpkins, A.N.1
Rudic, R.D.2
Schreihofer, D.A.3
Roy, S.4
Manhiani, M.5
Tsai, H.J.6
Hammock, B.D.7
Imig, J.D.8
-
14
-
-
69449093425
-
Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
-
Manhiani, M.; Quigley, J.E.; Knight, S.F.; Tasoobshirazi, S.; Moore, T.; Brands, M.W.; Hammock, B.D.; Imig, J.D. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am. J. Physiol. Renal Physiol. 2009, 297, F740–F748.
-
(2009)
Am. J. Physiol. Renal Physiol
, vol.297
, pp. F740-F748
-
-
Manhiani, M.1
Quigley, J.E.2
Knight, S.F.3
Tasoobshirazi, S.4
Moore, T.5
Brands, M.W.6
Hammock, B.D.7
Imig, J.D.8
-
15
-
-
0034711488
-
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids
-
Yu, Z.; Xu, F.; Huse, L.M.; Morisseau, C.; Draper, A.J.; Newman, J.W.; Parker, C.; Graham, L.; Engler, M.M.; Hammock, B.D.; Zeldin, D.C.; Kroetz, D.L. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ. Res. 2000, 87, 992–998.
-
(2000)
Circ. Res
, vol.87
, pp. 992-998
-
-
Yu, Z.1
Xu, F.2
Huse, L.M.3
Morisseau, C.4
Draper, A.J.5
Newman, J.W.6
Parker, C.7
Graham, L.8
Engler, M.M.9
Hammock, B.D.10
Zeldin, D.C.11
Kroetz, D.L.12
-
16
-
-
58849084528
-
Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice
-
Hercule, H.C.; Schunck, W.H.; Gross, V.; Seringer, J.; Leung, F.P.; Weldon, S.M.; da Costa Goncalves, A.; Huang, Y.; Luft, F.C.; Gollasch, M. Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arterioscler. Thromb. Vasc. Biol. 2009, 29, 54–60.
-
(2009)
Arterioscler. Thromb. Vasc. Biol
, vol.29
, pp. 54-60
-
-
Hercule, H.C.1
Schunck, W.H.2
Gross, V.3
Seringer, J.4
Leung, F.P.5
Weldon, S.M.6
da Costa Goncalves, A.7
Huang, Y.8
Luft, F.C.9
Gollasch, M.10
-
17
-
-
66349134398
-
Discovery of spirocylic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors
-
Shen, H.C.; Ding, F.X.; Wang, S.; Xu, S.; Chen, H.S.; Tong, X.; Mitra, K.; Kumar, S.; Zhang, X.; Chen, Y.; Zhou, G.; Pai, L.Y.; Alonso-Galicia, M.; Chen, X.; Zhang, B.; Tata, J.R. Berger, J.P.; Colletti, S.L. Discovery of spirocylic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorg. Med. Chem. Lett. 2009, 19, 3398–3404.
-
(2009)
Bioorg. Med. Chem. Lett
, vol.19
, pp. 3398-3404
-
-
Shen, H.C.1
Ding, F.X.2
Wang, S.3
Xu, S.4
Chen, H.S.5
Tong, X.6
Mitra, K.7
Kumar, S.8
Zhang, X.9
Chen, Y.10
Zhou, G.11
Pai, L.Y.12
Alonso-Galicia, M.13
Chen, X.14
Zhang, B.15
Tata, J.R.16
Berger, J.P.17
Colletti, S.L.18
-
18
-
-
1642460697
-
Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats
-
Mori, T.; Cowley, A.W., Jr. Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats. Hypertension 2004, 43, 752–759.
-
(2004)
Hypertension
, vol.43
, pp. 752-759
-
-
Mori, T.1
Cowley, A.W.2
-
19
-
-
67349209538
-
Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase
-
Parrish, A.R.; Chen, G.; Burghardt, R.C.; Watanabe, T.; Morisseau, C.; Hammock, B.D. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol. Toxicol. 2008, 25, 217–225.
-
(2008)
Cell Biol. Toxicol
, vol.25
, pp. 217-225
-
-
Parrish, A.R.1
Chen, G.2
Burghardt, R.C.3
Watanabe, T.4
Morisseau, C.5
Hammock, B.D.6
-
20
-
-
57049115027
-
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo
-
Motoki, A.; Merkel, M.J.; Packwood, W.H.; Cao, Z.; Liu, L.; Iliff, J.; Alkayed, N.J.; Van Winkle, D.M. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. Am. J. Physiol. Heart Circ. Physiol. 2008, 295, H2128–H2134.
-
(2008)
Am. J. Physiol. Heart Circ. Physiol
, vol.295
, pp. H2128-H2134
-
-
Motoki, A.1
Merkel, M.J.2
Packwood, W.H.3
Cao, Z.4
Liu, L.5
Iliff, J.6
Alkayed, N.J.7
Van Winkle, D.M.8
-
21
-
-
33845474465
-
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
-
Mateo. R.K
-
Xu, D.; Li, N.; He, Y.; Timofeyev, V.; Lu, L.; Tsai, H.J.; Kim, I.H.; Tuteja, D.; Mateo. R.K.; Singapuri, A.; Davis, B.B.; Low, R.; Hammock, B.D.; Chiamvimonvat, N. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc. Natl. Acad. Sci. USA 2006, 103, 18733–18738.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18733-18738
-
-
Xu, D.1
Li, N.2
He, Y.3
Timofeyev, V.4
Lu, L.5
Tsai, H.J.6
Kim, I.H.7
Tuteja, D.8
Singapuri, A.9
Davis, B.B.10
Low, R.11
Hammock, B.D.12
Chiamvimonvat, N.13
-
22
-
-
33747422507
-
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function
-
Seubert, J.M.; Sinal, C.J.; Graves, J.; DeGraff, L.M.; Bradbury, J.A.; Lee, C.R.; Goralski, K.; Carey, M.A.; Luria, A.; Newman, J.W.; Hammock, B.D.; Falck, J.R.; Roberts, H.; Rockman, H.A.; Murphy, E.; Zeldin, D.C. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ. Res. 2006, 99, 442–450.
-
(2006)
Circ. Res
, vol.99
, pp. 442-450
-
-
Seubert, J.M.1
Sinal, C.J.2
Graves, J.3
DeGraff, L.M.4
Bradbury, J.A.5
Lee, C.R.6
Goralski, K.7
Carey, M.A.8
Luria, A.9
Newman, J.W.10
Hammock, B.D.11
Falck, J.R.12
Roberts, H.13
Rockman, H.A.14
Murphy, E.15
Zeldin, D.C.16
-
23
-
-
33845351015
-
Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension
-
Franco, M.; Martinez, F.; Rodriguez-Iturbe, B.; Johnson, R.J.; Santamaria, J.; Montoya, A.; Nepomuceno, T.; Bautista, R.; Tapia, E.; Herrera-Acosta, J. Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension. Am. J. Physiol. Renal Physiol. 2006, 291, F1281–F1287.
-
(2006)
Am. J. Physiol. Renal Physiol
, vol.291
, pp. F1281-F1287
-
-
Franco, M.1
Martinez, F.2
Rodriguez-Iturbe, B.3
Johnson, R.J.4
Santamaria, J.5
Montoya, A.6
Nepomuceno, T.7
Bautista, R.8
Tapia, E.9
Herrera-Acosta, J.10
-
24
-
-
0037512517
-
Traditional and emerging cardiovascular risk factors in end-stage renal disease
-
Zoccali, C.; Mallamaci, F.; Tripepi, G. Traditional and emerging cardiovascular risk factors in end-stage renal disease. Kidney Int. 2003, 63, S105–S110.
-
(2003)
Kidney Int
, vol.63
, pp. S105-S110
-
-
Zoccali, C.1
Mallamaci, F.2
Tripepi, G.3
-
25
-
-
0035538361
-
Renin-angiotensin system and renal damage: emerging data on angiotensin II as a proinflammatory mediator
-
Ruiz-Ortega, M.; Lorenzo, O.; Ruperez, M.; Esteban, V.; Mezzano, S.; Egido, J. Renin-angiotensin system and renal damage: emerging data on angiotensin II as a proinflammatory mediator. Contrib. Nephrol. 2001, 135, 123–137.
-
(2001)
Contrib. Nephrol
, vol.135
, pp. 123-137
-
-
Ruiz-Ortega, M.1
Lorenzo, O.2
Ruperez, M.3
Esteban, V.4
Mezzano, S.5
Egido, J.6
-
26
-
-
36448998082
-
Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertension
-
Elmarakby, A.A.; Quigley, J.E.; Olearczyk, J.J.; Sridhar, A.; Cook, A.K.; Inscho, E.W.; Pollock, D.M.; Imig, J.D. Chemokine receptor 2b inhibition provides renal protection in angiotensin II-salt hypertension. Hypertension 2007, 50, 1069–1076.
-
(2007)
Hypertension
, vol.50
, pp. 1069-1076
-
-
Elmarakby, A.A.1
Quigley, J.E.2
Olearczyk, J.J.3
Sridhar, A.4
Cook, A.K.5
Inscho, E.W.6
Pollock, D.M.7
Imig, J.D.8
-
27
-
-
0036841091
-
Immunosuppressive treatment protects against angiotensin II-induced renal damage
-
Muller, D.N.; Shagdarsuren, E.; Park, J.K.; Dechend, R.; Mervaala, E.; Hampich, F.; Fiebeler, A.; Ju, X.; Finckenberg, P.; Theuer, J.; Viedt, C.; Kreuzer, J.; Heidecke, H.; Haller, H.; Zenke, M.; Luft, F.C. Immunosuppressive treatment protects against angiotensin II-induced renal damage. Am. J. Pathol. 2002, 161, 1679–1693.
-
(2002)
Am. J. Pathol
, vol.161
, pp. 1679-1693
-
-
Muller, D.N.1
Shagdarsuren, E.2
Park, J.K.3
Dechend, R.4
Mervaala, E.5
Hampich, F.6
Fiebeler, A.7
Ju, X.8
Finckenberg, P.9
Theuer, J.10
Viedt, C.11
Kreuzer, J.12
Heidecke, H.13
Haller, H.14
Zenke, M.15
Luft, F.C.16
-
28
-
-
34948825774
-
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
-
Guzik, T.J.; Hoch, N.E.; Brown, K.A.; McCann, L.A.; Rahman, A.; Dikalov, S.; Goronzy, J.; Weyand, C.; Harrison, D.G. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J. Exp. Med. 2007, 204, 2449–2460.
-
(2007)
J. Exp. Med
, vol.204
, pp. 2449-2460
-
-
Guzik, T.J.1
Hoch, N.E.2
Brown, K.A.3
McCann, L.A.4
Rahman, A.5
Dikalov, S.6
Goronzy, J.7
Weyand, C.8
Harrison, D.G.9
-
29
-
-
61949197524
-
Regulation of T-cell function by endogenously produced angiotensin II
-
Hoch, N.E.; Guzik, T.J.; Chen, W.; Deans, T.; Maalouf, S.A.; Gratze, P.; Weyand, C.; Harrison, D.G. Regulation of T-cell function by endogenously produced angiotensin II. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296, R208–R216.
-
(2009)
Am. J. Physiol. Regul. Integr. Comp. Physiol
, vol.296
, pp. R208-R216
-
-
Hoch, N.E.1
Guzik, T.J.2
Chen, W.3
Deans, T.4
Maalouf, S.A.5
Gratze, P.6
Weyand, C.7
Harrison, D.G.8
-
30
-
-
34047218002
-
Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats
-
Kang, K.T.; Sullivan, J.C.; Sasser, J.M.; Imig, J.D.; Pollock, J.S. Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats. Hypertension 2007, 49, 893–901.
-
(2007)
Hypertension
, vol.49
, pp. 893-901
-
-
Kang, K.T.1
Sullivan, J.C.2
Sasser, J.M.3
Imig, J.D.4
Pollock, J.S.5
-
31
-
-
0037076294
-
Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma
-
Diep, Q.N.; El Mabrouk, M.; Cohn, J.S.; Endemann, D.; Amiri, F.; Virdis, A.; Neves, M.F.; Schiffrin, E.L. Structure, endothelial function, cell growth, and inflammation in blood vessels of angiotensin II-infused rats: role of peroxisome proliferator-activated receptor-gamma. Circulation 2002, 105, 2296–2302.
-
(2002)
Circulation
, vol.105
, pp. 2296-2302
-
-
Diep, Q.N.1
El Mabrouk, M.2
Cohn, J.S.3
Endemann, D.4
Amiri, F.5
Virdis, A.6
Neves, M.F.7
Schiffrin, E.L.8
-
32
-
-
14044262246
-
Nitric oxide, angiotensin II, and reactive oxygen species in hypertension and atherogenesis
-
Schulman, I.H.; Zhou, M.S.; Raij, L. Nitric oxide, angiotensin II, and reactive oxygen species in hypertension and atherogenesis. Curr. Hypertens. Rep. 2005, 7, 61–67.
-
(2005)
Curr. Hypertens. Rep
, vol.7
, pp. 61-67
-
-
Schulman, I.H.1
Zhou, M.S.2
Raij, L.3
-
33
-
-
0033774380
-
Renin-angiotensin system blockade improves endothelial dysfunction in hypertension
-
Goto, K.; Fujii, K.; Onaka, U.; Abe, I.; Fujishima, M. Renin-angiotensin system blockade improves endothelial dysfunction in hypertension. Hypertension 2000, 36, 575–580.
-
(2000)
Hypertension
, vol.36
, pp. 575-580
-
-
Goto, K.1
Fujii, K.2
Onaka, U.3
Abe, I.4
Fujishima, M.5
|