Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells

Journal of Hepatology

Volumn 54, Issue 2, 2011, Pages 328-339

  Tak, Eunyoung ^a   Lee, Seonmin ^a   Lee, Jisun ^a   Rashid, M A ^a   Kim, Youn Wha ^a   Park, Jae Hoon ^a   Park, Won Sang ^b   Shokat, Kevan M ^c   Ha, Joohun ^a   Kim, Sung Soo ^a  

^a Kyung Hee University Hospital   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CBR1; HCC; HIF 1 ; Lipid peroxidation; ROS

Indexed keywords

CARBONYL REDUCTASE; CARBONYL REDUCTASE 1; CISPLATIN; DOXORUBICIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CELL CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR GROWTH; WESTERN BLOTTING;

ALCOHOL OXIDOREDUCTASES; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL HYPOXIA; CELL LINE, TUMOR; CISPLATIN; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; UP-REGULATION;

EID: 78751580282     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.06.045     Document Type: Article

References (34)

1. F. Hoffmann, and E. Maser Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily Drug Metab Rev 39 2007 87 144
2. U. Oppermann Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology Annu Rev Pharmacol Toxicol 47 2007 293 322
3. 2 tension Proc Natl Acad Sci USA 92 1995 5510 5514
4. E.C. Hoffman, H. Reyes, F.F. Chu, F. Sander, L.H. Conley, and B.A. Brooks Cloning of a factor required for activity of the Ah (dioxin) receptor Science 252 1991 954 958
5. 2-regulated prolyl hydroxylation Science 292 2001 468 472
6. 2 sensing Science 292 2001 464 468
7. Aravalli N. Rajagopal, Clifford J. Steer, and Erik N.K. Cressman Molecular mechanisms of hepatocellular carcinoma Hepatology 48 2008 2047 2063
8. J.L. Raoul Natural history of hepatocellular carcinoma and current treatment options Semin Nucl Med 38 2008 S13 S18
9. K. Yamakado, A. Nakatsuka, H. Takaki, H. Yokoi, M. Usui, and H. Sakurai Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy Radiology 247 2008 260 266
10. M. Nabil, T. Gruber, D. Yakoub, H. Ackermann, S. Zangos, and T.J. Vogl Repetitive transarterial chemoembolization (TACE) of liver metastases from renal cell carcinoma: local control and survival results Eur Radiol 18 2008 1456 1463
11. Josep M. Llovet, and Jordi Bruix Molecular targeted therapies in hepatocellular carcinoma Hepatology 48 2008 1312 1327
12. G.L. Semenza Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis Hematol Oncol Clin North Am 8 1994 863 884
13. X. Gao, J.L. Campian, M. Qian, X.F. Sun, and J.W. Eaton Mitochondrial DNA damage in iron overload J Biol Chem 284 2009 4767 4775
14. M. Haque, D.A. Davis, V. Wang, I. Widmer, and R. Yarchoan Kaposi's sarcoma-associated herpes virus (human herpes virus 8) contains hypoxia response elements: relevance to lytic induction by hypoxia J Virol 77 2003 6761 6768
15. K.J. Choi, Y.J. Piao, M.J. Lim, J.H. Kim, J. Ha, and W. Choe Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death Cancer Res 678 2007 3654 3662
16. J. Kim, T.G. Choi, Y. Ding, Y. Kim, K.S. Ha, and K.H. Lee Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress J Cell Sci 121 2008 3636 3648
17. P. Carmeliet, Y. Dor, J.M. Herbert, D. Fukumura, K. Brusselmans, and M. Dewerchin Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature 394 1998 485 490
18. 2 homeostasis by hypoxia-inducible factor Annu Rev Cell Dev Biol 15 1999 551 578
19. M. Satoh, N. Kashihara, S. Fujimoto, H. Horike, T. Tokura, and T. Namikoshi A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo J Pharmacol Exp Ther 305 2003 1183 1190
20. Z.H. Siddik Cisplatin: mode of cytotoxic action and molecular basis of resistance Oncogene 22 2003 7265 7279
21. G. Poli, R.J. Schaur, W.G. Siems, and G. Leonarduzzi 4-Hydroxynonenal: a membrane lipid oxidation product of medicinal interest Med Res Rev 28 2008 569 631
22. M. Tanaka, R. Bateman, D. Rauh, E. Vaisberg, S. Ramachandani, and C. Zhang An unbiased cell morphology-based screen for new, biologically active small molecules PLoS Biol 3 2005 764 776
23. E.M. Ellis Reactive carbonyls and oxidative stress: potential for therapeutic intervention Pharmacol Ther 115 2007 13 24
24. M.K. Kwak, N. Wakabayashi, K. Itoh, H. Motohashi, M. Yamamoto, and T.W. Kensler Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival J Biol Chem 278 2003 8135 8145
25. R.K. Thimmulappa, K.H. Mai, S. Srisuma, and T.W. Kensler Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray Cancer Res 62 2002 5196 5203
26. E. Maser Neuroprotective role for carbonyl reductase? Biochem Biophys Res Commun 340 2006 1019 1022
27. S.S. Lakhman, X. Chen, V. Gonzalez-Covarrubias, E.G. Schuetz, and J.G. Blanco Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor Mol Pharmacol 72 2007 734 743
28. P.J. Kallio, I. Pongratz, K. Gradin, J. McGuire, and L. Poellinger Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor Proc Natl Acad Sci 94 1997 5667 5672
29. H. Kimura, A. Weisz, T. Ogura, Y. Hitomi, Y. Kurashima, and K. Hashimoto Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide J Biol Chem 276 2001 2292 2298
30. T. Klimova, and N.S. Chandel Mitochondrial complex III regulates hypoxic activation of HIF Cell Death Differ 15 2008 660 666
31. W.G. Kaelin Jr. ROS: really involved in oxygen sensing Cell Metab 1 2005 357 358
32. R.S. Balaban, S. Nemoto, and T. Finkel Mitochondria, oxidants, and aging Cell 120 2005 483 495
33. Z. Dong, M.A. Venkatachalam, J. Wang, Y. Patel, P. Saikumar, and G.L. Semenza Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms J Biol Chem 276 2001 18702 18709
34. G.L. Semenza HIF-1: mediator of physiological and pathophysiological responses to hypoxia J Appl Physiol 88 2000 1474 1480