Bacteriostatic activity of the proregion of human hepcidin

Protein and Peptide Letters

Volumn 18, Issue 1, 2011, Pages 36-40

  Barthe, Christophe ^a,c   Hocquellet, Agnès ^a,b,c   Garbay, Bertrand ^a,b,c  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b Institut Polytechnique de Bordeaux   (France)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Antimicrobial peptide; DNA binding; Hepcidin; Proregion

Indexed keywords

BACILLUS MEGATERIUM; BACILLUS SUBTILIS; MAMMALIA;

EID: 78751528711     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986611794328627     Document Type: Article

References (27)

1. Krause, A.; Neitz, S.; Mägert, H.J.; Schulz, A.; Forssmann, W.G.; Schulz-Knappe, P.; Adermann, K. LEAP-1, a novel highly disulfide- bonded human peptide, exhibits antimicrobial activity. FEBS Lett., 2000, 480, 147-150.
2. Park, C.H.; Valore, E.V.; Waring, A.J.; Ganz, T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem., 2001, 276, 7806-7810.
3. Nemeth, E.; Tuttle, M.S.; Powelson, J.; Vaughn, M.B.; Donovan, A.; Ward, D.M.; Ganz, T.; Kaplan, J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 2004, 306, 2090-2093.
4. Gagliardo, B.; Kubat, N.; Faye, A.; Jaouen, M.; Durel, B.; Deschemin, J.C.; Canonne-Hergaux, F.; Sari, M.A.; Vaulont, S. Pro-hepcidin is unable to degrade the iron exporter ferroportin unless maturated by a furin-dependent process. J. Hepatol., 2009, 50, 394-401.
5. Valore, E.V.; Ganz, T. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol. Dis., 2008, 40, 132-138.
6. Wiegand, I.; Hilpert, K.; Hancock, R.E. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Nature Protocols, 2008, 2, 163-174.
7. Bourbon, C.; Bry, C.; Roggemans, C.; Soulard, C.; Thizon, C.; Garbay, B. Use of a real-time polymerase chain reaction thermocycler to study bacterial cell permeabilization by antimicrobial peptides. Anal. Biochem., 2008, 381, 279-281.
8. Roth, B.L.; Poot, M.; Yue, S.T.; Millard, P.J. Bacterial viability and antibiotic susceptibility testing with SYTOX Green nucleic acid stain. Appl. Environ. Microbiol., 1997, 63, 2421-2431.
9. Park, C.B.; Kim, H.S.; Kim, S.C. Mechanism of action of the antimicrobial peptide buforin II: Buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys. Res. Commun., 1998, 244, 253-257.
10. Zasloff, M.; Martin, B.; Chen H.C. Antimicrobial activity of synthetic magainin peptides and several analogues. Proc. Natl. Acad. Sci., 1988, 85, 910-913.
11. Johansson, J.; Gudmundsson, G.H.; Rottenberg, M.E.; Berndt, K.D.; Agerberth, B. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem., 1998, 273, 3718-3724.
12. Jenssen, H.; Hamill, P.; Hancock, R.E.W. Peptide antimicrobial agents. Clin. Microbiol. Rev., 2006, 19, 491-511.
13. Powers, J.P.S.; Hancock, R.E.W. The relationship between peptide structure and antibacterial activity. Peptides, 2003, 24, 1681-1691.
14. Oren, Z.; Lerman, J.C.; Gudmundsson, G.H.; Agerberth, B.; Shai, Y. Structure and organization of the human antimicrobial peptide LL-37 in phospholipids membranes: Relevance to the molecular basis for its non-cell-selective activity. Biochem. J., 1999, 341, 501-513.
15. Matsuzaki, K.; Sugishita, K.I.; Harada, M.; Fujii, N.; Miyajima, K. Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria. Biochim. Biophys. Acta, 1997, 1327, 119-130.
16. Suter, U.; Heymach, J.V.; Shooter, E.M. Two conserved domains in the NGF proregion are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J., 1991, 10, 2395-2400.
17. Rattenholl, A.; Ruoppolo, M.; Flagiello, A.; Monti, M.; Vinci, F.; Marino, G.; Lilie, H.; Schwarz, E.; Rudolph, R. Pro-sequence assisted in the folding and disulfide bond formation of human nerve growth factor. J. Mol. Biol., 2001, 305, 523-533. (Pubitemid 33032859)
18. Michaelson, D.; Rayner, J.; Couto, M.; Ganz, T. Cationic defensins arise from charge-neutralized proregions: A mechanism for avoiding leukocyte autocytotoxicity? J. Leukoc. Biol., 1992, 51, 634-639.
19. Valore, E.V.; Martin, E.; Harwig, S.S.; Ganz, T. Intramolecular inhibition of human defensin HNP-1 by its propiece. J. Clin. Invest., 1996, 97, 1624-1629.
20. Dicou, E. Multiple biological activities for two peptides derived from the nerve growth factor precursor. Biochem. Biophys. Res. Commun., 2006, 347, 833-837.
21. Storici, P.; Tossi, A.; Lenarcic, B.; Romeo, D. Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides. Eur. J. Biochem., 1996, 238, 769-776.
22. Yang, L.; Johansson, J.; Ridsdale, R.; Willander, H.; Fitzen, M.; Akinbi, H.T.; Weaver, T.E. Surfactant protein B proregion contains a saposin-like protein domain with antimicrobial activity at low pH. J. Immunol., 2010, 184, 975-983.
23. Brogden, K.A.; Ackermann, M.; Huttner, K.M. Small, anionic, and charge-neutralizing proregion fragments of zymogens are antimicrobial. Antimicrob. Agents Chemother., 1997, 41, 1615-1617.
24. Zaiou, M.; Nizet, V.; Gallo, R.L. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J. Invest. Dermatol., 2003, 120, 810-816.
25. Sharma, S.; Khuller, G. DNA as the intracellular secondary target for antibacterial action of human neutrophil peptide-I against Mycobacterium tuberculosis. Curr. Microbiol., 2001, 43, 74-76.
26. Ulvatne, H.; Samuelsen, Ø.; Haukland, H.H.; Krämer, M.; Vorland, L.H. Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis. FEMS Microbiol. Lett., 2004, 237, 377-384.
27. Hocquellet, A.; Odaert, B.; Cabanne, C.; Noubhani, A.; Dieryck, W.; Joucla, G.; Le Senechal, C.; Milenkov, M.; Chaignepain, S.; Schmitter, J.M.; Claverol, S.; Santarelli, X.; Dufourc, E.J.; Bonneu, M.; Garbay, B.; Costaglioli, P. Structure-activity relationship of human liver-expressed antimicrobial peptide 2. Peptides, 2010, 31(1), 58-66.