Lipid signalling in pathogenic fungi

Cellular Microbiology

Volumn 13, Issue 2, 2011, Pages 177-185

  Singh, Arpita ^a   Del Poeta, Maurizio ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOL; LIPID; OXYLIPIN; SPHINGOLIPID; VIRULENCE FACTOR;

ASPERGILLUS FUMIGATUS; BIOFILM; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; FUNGUS; MAMMAL CELL; MOULD; MYCELIAL GROWTH; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; QUORUM SENSING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRESS;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; LIPID METABOLISM; QUORUM SENSING; SIGNAL TRANSDUCTION; VIRULENCE; VIRULENCE FACTORS;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; FUNGI; MAMMALIA;

EID: 78651441292     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2010.01550.x     Document Type: Review

References (106)

1. Aerts, A.M., Francois, I.E., Cammue, B.P., and Thevissen, K. (2008) The mode of antifungal action of plant, insect and human defensins. Cell Mol Life Sci 65: 2069-2079.
2. Aerts, A.M., Carmona-Gutierrez, D., Lefevre, S., Govaert, G., Francois, I.E., Madeo, F., et al. (2009) The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans. FEBS Lett 583: 2513-2516.
3. 2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Curr Biol 15: 2013-2020.
4. Bielawski, J., Pierce, J.S., Snider, J., Rembiesa, B., Szulc, Z.M., and Bielawska, A. (2010) Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Adv Exp Med Biol 688: 46-59.
5. Braun, B.R., and Johnson, A.D. (1997) Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 277: 105-109.
6. Braun, B.R., Kadosh, D., and Johnson, A.D. (2001) NRG1, a repressor of filamentous growth in C. albicans, is down-regulated during filament induction. EMBO J 20: 4753-4761.
7. Cheng, J., Park, T.S., Fischl, A.S., and Ye, X.S. (2001) Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans. Mol Cell Biol 21: 6198-6209.
8. Cheng, J., Park, T.S., Chio, L.C., Fischl, A.S., and Ye, X.S. (2003) Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. Mol Cell Biol 23: 163-177.
9. Deveau, A., Piispanen, A.E., Jackson, A.A., and Hogan, D.A. (2010) Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway. Eukaryot Cell 9: 569-577.
10. Dichtl, K., Ebel, F., Dirr, F., Routier, F.H., Heesemann, J., and Wagener, J. (2010) Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus. Mol Microbiol 76: 1191-1204.
11. Edwards, P.A., and Ericsson, J. (1999) Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu Rev Biochem 68: 157-185.
12. Enjalbert, B., and Whiteway, M. (2005) Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth. Eukaryot Cell 4: 1203-1210.
13. Enjalbert, B., Smith, D.A., Cornell, M.J., Alam, I., Nicholls, S., Brown, A.J., and Quinn, J. (2006) Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans. Mol Biol Cell 17: 1018-1032.
14. Erb-Downward, J.R., and Huffnagle, G.B. (2007) Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase. Eukaryot Cell 6: 346-350.
15. Erb-Downward, J.R., and Noverr, M.C. (2007) Characterization of prostaglandin E2 production by Candida albicans. Infect Immun 75: 3498-3505.
16. Erb-Downward, J.R., Noggle, R.M., Williamson, P.R., and Huffnagle, G.B. (2008) The role of laccase in prostaglandin production by Cryptococcus neoformans. Mol Microbiol 68: 1428-1437.
17. Fairn, G.D., Macdonald, K., and McMaster, C.R. (2007) A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. J Biol Chem 282: 4868-4874.
18. Fan, W., Kraus, P.R., Boily, M.J., and Heitman, J. (2005) Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryot Cell 4: 1420-1433.
19. Farhang-Fallah, J., Randhawa, V.K., Nimnual, A., Klip, A., Bar-Sagi, D., and Rozakis-Adcock, M. (2002) The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol Cell Biol 22: 7325-7336.
20. Fox, T.E., and Kester, M. (2010) Therapeutic strategies for diabetes and complications: a role for sphingolipids? Adv Exp Med Biol 688: 206-216.
21. Garcia, J., Shea, J., Alvarez-Vasquez, F., Qureshi, A., Luberto, C., Voit, E.O., and Del Poeta, M. (2008b) Mathematical modeling of pathogenicity of Cryptococcus neoformans. Mol System Biology 4: 183-195.
22. Garcia, J., Shea, J., Alvarez-Vasquez, F., Qureshi, A., Luberto, C., Voit, E.O., and Del Poeta, M. (2008a) Mathematical modeling of pathogenicity of Cryptococcus neoformans. Mol Syst Biol 4: 183.
23. Garscha, U., Jerneren, F., Chung, D., Keller, N.P., Hamberg, M., and Oliw, E.H. (2007) Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J Biol Chem 282: 34707-34718.
24. Gault, C.R., Obeid, L.M., and Hannun, Y.A. (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 688: 1-23.
25. Gomez-Munoz, A., Gangoiti, P., Granado, M.H., Arana, L., and Ouro, A. (2010) Ceramide-1-phosphate in cell survival and inflammatory signaling. Adv Exp Med Biol 688: 118-130.
26. Hannun, Y.A., Loomis, C.R., Merrill, A.H., Jr, and Bell, R.M. (1986) Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 261: 12604-12609.
27. Heidler, S.A., and Radding, J.A. (2000) Inositol phosphoryl transferases from human pathogenic fungi. Biochim Biophys Acta 1500: 147-152.
28. Heung, L.J., Luberto, C., Plowden, A., Hannun, Y.A., and Del Poeta, M. (2004) The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem 279: 21144-21153.
29. Hinkovska-Galcheva, V., and Shayman, J.A. (2010) Ceramide-1-phosphate in phagocytosis and calcium homeostasis. Adv Exp Med Biol 688: 131-140.
30. Holthuis, J.C., and Luberto, C. (2010) Tales and mysteries of the enigmatic sphingomyelin synthase family. Adv Exp Med Biol 688: 72-85.
31. Hornby, J.M., Jensen, E.C., Lisec, A.D., Tasto, J.J., Jahnke, B., Shoemaker, R., et al. (2001) Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67: 2982-2992.
32. Jenkins, G.M., Richards, A., Wahl, T., Mao, C., Obeid, L., and Hannun, Y. (1997) Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem 272: 32566-32572.
33. Joo, J.H., and Jetten, A.M. (2010) Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett 287: 123-135.
34. Kadosh, D., and Johnson, A.D. (2001) Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans. Mol Cell Biol 21: 2496-2505.
35. Kaneko, A., Umeyama, T., Utena-Abe, Y., Yamagoe, S., Niimi, M., and Uehara, Y. (2006) Tcc1p, a novel protein containing the tetratricopeptide repeat motif, interacts with Tup1p to regulate morphological transition and virulence in Candida albicans. Eukaryot Cell 5: 1894-1905.
36. Kawamori, T. (2010) Animal models for studying the pathophysiology of ceramide. Adv Exp Med Biol 688: 109-117.
37. Kechichian, T.B., Shea, J., and Del Poeta, M. (2007) Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice. Infect Immun 75: 4792-4798.
38. Khalaf, R.A., and Zitomer, R.S. (2001) The DNA binding protein Rfg1 is a repressor of filamentation in Candida albicans. Genetics 157: 1503-1512.
39. Kleinhans, F.W., Lees, N.D., Bard, M., Haak, R.A., and Woods, R.A. (1979) ESR determinations of membrane permeability in a yeast sterol mutant. Chem Phys Lipids 23: 143-154.
40. Klopfenstein, D.R., and Vale, R.D. (2004) The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell 15: 3729-3739.
41. Kruppa, M. (2009) Quorum sensing and Candida albicans. Mycoses 52: 1-10.
42. Kuroda, E., and Yamashita, U. (2003) Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB/c mice. J Immunol 170: 757-764.
43. Lee, H., Chang, Y.C., Nardone, G., and Kwon-Chung, K.J. (2007) TUP1 disruption in Cryptococcus neoformans uncovers a peptide-mediated density-dependent growth phenomenon that mimics quorum sensing. Mol Microbiol 64: 591-601.
44. Lee, H., Chang, Y.C., Varma, A., and Kwon-Chung, K.J. (2009) Regulatory diversity of TUP1 in Cryptococcus neoformans. Eukaryot Cell 8: 1901-1908.
45. Lees, N.D., Bard, M., Kemple, M.D., Haak, R.A., and Kleinhans, F.W. (1979) ESR determination of membrane order parameter in yeast sterol mutants. Biochim Biophys Acta 553: 469-475.
46. Levery, S.B., Momany, M., Lindsey, R., Toledo, M.S., Shayman, J.A., Fuller, M., et al. (2002) Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth. FEBS Lett 525: 59-64.
47. Luberto, C., Toffaletti, D.L., Wills, E.A., Tucker, S.C., Casadevall, A., Perfect, J.R., et al. (2001) Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev 15: 201-212.
48. Luberto, C., Martinez-Marino, B., Taraskiewicz, D., Bolanos, B., Chitano, P., Toffaletti, D.L., et al. (2003) Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest 112: 1080-1094.
49. Mare, L., Iatta, R., Montagna, M.T., Luberto, C., and Del Poeta, M. (2005) APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans. J Biol Chem 280: 36055-36064.
50. Martin, S.W., and Konopka, J.B. (2004) Lipid raft polarization contributes to hyphal growth in Candida albicans. Eukaryot Cell 3: 675-684.
51. Merrill, A.H., Jr, Sereni, A.M., Stevens, V.L., Hannun, Y.A., Bell, R.M., and Kinkade, J.M., Jr (1986) Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem 261: 12610-12615.
52. Messner, M.C., and Cabot, M.C. (2010) Glucosylceramide in humans. Adv Exp Med Biol 688: 156-164.
53. 2 sensing: a breath of fresh air. Curr Biol 15: R934-R936.
54. Mitchell, A.P. (2006) Cryptococcal virulence: beyond the usual suspects. J Clin Invest 116: 1481-1483.
55. 2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot Cell 5: 103-111.
56. Nagiec, M.M., Skrzypek, M., Nagiec, E.E., Lester, R.L., and Dickson, R.C. (1998) The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem 273: 19437-19442.
57. Nickerson, K.W., Atkin, A.L., and Hornby, J.M. (2006) Quorum sensing in dimorphic fungi: farnesol and beyond. Appl Environ Microbiol 72: 3805-3813.
58. Nigam, S., Ciccoli, R., Ivanov, I., Sczepanski, M., and Deva, R. (2010) On mechanism of quorum sensing in candida albicans by 3(R)-hydroxy-tetradecaenoic acid. Curr Microbiol DOI: 10.1007/s00284-010-9666-6.
59. Nikolova-Karakashian, M.N., and Rozenova, K.A. (2010) Ceramide in stress response. Adv Exp Med Biol 688: 86-108.
60. Noble, S.M., French, S., Kohn, L.A., Chen, V., and Johnson, A.D. (2010) Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet 42: 590-598.
61. Noverr, M.C., Phare, S.M., Toews, G.B., Coffey, M.J., and Huffnagle, G.B. (2001) Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect Immun 69: 2957-2963.
62. Noverr, M.C., Williamson, P.R., Fajardo, R.S., and Huffnagle, G.B. (2004) CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence. Infect Immun 72: 1693-1699.
63. Oberholzer, U., Nantel, A., Berman, J., and Whiteway, M. (2006) Transcript profiles of Candida albicans cortical actin patch mutants reflect their cellular defects: contribution of the Hog1p and Mkc1p signaling pathways. Eukaryot Cell 5: 1252-1265.
64. Oskouian, B., and Saba, J.D. (2010) Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol 688: 185-205.
65. Oura, T., and Kajiwara, S. (2008) Disruption of the sphingolipid Delta8-desaturase gene causes a delay in morphological changes in Candida albicans. Microbiology 154: 3795-3803.
66. Oura, T., and Kajiwara, S. (2010) Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation. Microbiology 156: 1234-1243.
67. Patton, J.L., Srinivasan, B., Dickson, R.C., and Lester, R.L. (1992) Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J Bacteriol 174: 7180-7184.
68. Plesofsky, N.S., Levery, S.B., Castle, S.A., and Brambl, R. (2008) Stress-induced cell death is mediated by ceramide synthesis in Neurospora crassa. Eukaryot Cell 7: 2147-2159.
69. Ramage, G., and Lopez-Ribot, J.L. (2005) Techniques for antifungal susceptibility testing of Candida albicans biofilms. Methods Mol Med 118: 71-79.
70. Ramage, G., Saville, S.P., Wickes, B.L., and Lopez-Ribot, J.L. (2002) Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol 68: 5459-5463.
71. Ramage, G., Saville, S.P., Thomas, D.P., and Lopez-Ribot, J.L. (2005) Candida biofilms: an update. Eukaryot Cell 4: 633-638.
72. Ramamoorthy, V., Cahoon, E.B., Thokala, M., Kaur, J., Li, J., and Shah, D.M. (2009) Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum. Eukaryot Cell 8: 217-229.
73. Rhome, R., and Del Poeta, M. (2010) Sphingolipid signaling in fungal pathogens. Adv Exp Med Biol 688: 232-237.
74. Rhome, R., McQuiston, T., Kechichian, T., Bielawska, A., Hennig, M., Drago, M., et al. (2007) Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens. Eukaryot Cell 6: 1715-1726.
75. Riboni, L., Giussani, P., and Viani, P. (2010) Sphingolipid transport. Adv Exp Med Biol 688: 24-45.
76. Rittershaus, P.C., Kechichian, T.B., Allegood, J.C., Merrill, A.H., Jr, Hennig, M., Luberto, C., and Del Poeta, M. (2006) Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J Clin Invest 116: 1651-1659.
77. Sebolai, O.M., Pohl, C.H., Botes, P.J., Strauss, C.J., van Wyk, P.W., Botha, A., and Kock, J.L. (2007) 3-hydroxy fatty acids found in capsules of Cryptococcus neoformans. Can J Microbiol 53: 809-812.
78. Sebolai, O.M., Pohl, C.H., Botes, P.J., van Wyk, P.W., and Kock, J.L. (2008) The influence of acetylsalicylic acid on oxylipin migration in Cryptococcus neoformans var. neoformans UOFS Y-1378. Can J Microbiol 54: 91-96.
79. Semighini, C.P., Hornby, J.M., Dumitru, R., Nickerson, K.W., and Harris, S.D. (2006) Farnesol-induced apoptosis in Aspergillus nidulans reveals a possible mechanism for antagonistic interactions between fungi. Mol Microbiol 59: 753-764.
80. Shea, J.M., and Del Poeta, M. (2006) Lipid signaling in pathogenic fungi. Curr Opin Microbiol 9: 352-358.
81. Shea, J.M., Kechichian, T.B., Luberto, C., and Del Poeta, M. (2006) The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system. Infect Immun 74: 5977-5988.
82. Siafakas, A.R., Wright, L.C., Sorrell, T.C., and Djordjevic, J.T. (2006) Lipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu/Zn superoxide dismutase. Eukaryot Cell 5: 488-498.
83. Siafakas, A.R., Sorrell, T.C., Wright, L.C., Wilson, C., Larsen, M., Boadle, R., et al. (2007) Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity. J Biol Chem 282: 37508-37514.
84. Smal, J., and De Meyts, P. (1989) Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. Proc Natl Acad Sci USA 86: 4705-4709.
85. Smith, D.A., Nicholls, S., Morgan, B.A., Brown, A.J., and Quinn, J. (2004) A conserved stress-activated protein kinase regulates a core stress response in the human pathogen Candida albicans. Mol Biol Cell 15: 4179-4190.
86. Sonnino, S., and Prinetti, A. (2010) Gangliosides as regulators of cell membrane organization and functions. Adv Exp Med Biol 688: 165-184.
87. Spiegel, S. (1999) Sphingosine 1-phosphate: a prototype of a new class of second messengers. J Leukoc Biol 65: 341-344.
88. Stiban, J., Tidhar, R., and Futerman, A.H. (2010) Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol 688: 60-71.
89. Strub, G.M., Maceyka, M., Hait, N.C., Milstien, S., and Spiegel, S. (2010) Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol 688: 141-155.
90. Tanimoto, T., Onodera, K., Hosoya, T., Takamatsu, Y., Kinoshita, T., Tago, K., et al. (1996) Schizostatin, a novel squalene synthase inhibitor produced by the mushroom, Schizophyllum commune. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot 49: 617-623.
91. Tavares, P.M., Thevissen, K., Cammue, B.P., Francois, I.E., Barreto-Bergter, E., Taborda, C.P., et al. (2008) In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis. Antimicrob Agents Chemother 52: 4522-4525.
92. Ternes, P., Sperling, P., Albrecht, S., Franke, S., Cregg, J.M., Warnecke, D., and Heinz, E. (2006) Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem 281: 5582-5592.
93. Thevissen, K., Warnecke, D.C., Francois, I.E., Leipelt, M., Heinz, E., Ott, C., et al. (2004) Defensins from insects and plants interact with fungal glucosylceramides. J Biol Chem 279: 3900-3905.
94. Thevissen, K., Kristensen, H.H., Thomma, B.P., Cammue, B.P., and Francois, I.E. (2007) Therapeutic potential of antifungal plant and insect defensins. Drug Discov Today 12: 966-971.
95. Tommasino, N., Villani, M., Qureshi, A., Henry, J., Luberto, C., and Del Poeta, M. (2008) Atf2 transcription factor binds to the APP1 promoter in Cryptococcus neoformans: stimulatory effect of diacylglycerol. Eukaryot Cell 7: 294-301.
96. Tsitsigiannis, D.I., and Keller, N.P. (2007) Oxylipins as developmental and host-fungal communication signals. Trends Microbiol 15: 109-118.
97. Tsitsigiannis, D.I., Bok, J.W., Andes, D., Nielsen, K.F., Frisvad, J.C., and Keller, N.P. (2005) Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect Immun 73: 4548-4559.
98. Uhl, M.A., Biery, M., Craig, N., and Johnson, A.D. (2003) Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J 22: 2668-2678.
99. Voit, E.O. (2000) Computational Analysis of Biochemical System. A Practical Guide for Biochemists and Molecular Biologists. Cambridge: Cambridge University Press.
100. Warnecke, D., and Heinz, E. (2003) Recently discovered functions of glucosylceramides in plants and fungi. Cell Mol Life Sci 60: 919-941.
101. Weber, K., Schulz, B., and Ruhnke, M. (2010) The quorum-sensing molecule E, E-farnesol-its variable secretion and its impact on the growth and metabolism of Candida species. Yeast 27: 727-739.
102. Wells, G.B., Dickson, R.C., and Lester, R.L. (1998) Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem 273: 7235-7243.
103. Westwater, C., Balish, E., and Schofield, D.A. (2005) Candida albicans-conditioned medium protects yeast cells from oxidative stress: a possible link between quorum sensing and oxidative stress resistance. Eukaryot Cell 4: 1654-1661.
104. Wilson, E., Olcott, M.C., Bell, R.M., Merrill, A.H., Jr, and Lambeth, J.D. (1986) Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. J Biol Chem 261: 12616-12623.
105. Wymann, M.P., and Schneiter, R. (2008) Lipid signalling in disease. Nat Rev Mol Cell Biol 9: 162-176.
106. Zauner, S., Ternes, P., and Warnecke, D. (2010) Biosynthesis of sphingolipids in plants (and some of their functions). Adv Exp Med Biol 688: 249-263.