Cryptococcal virulence: Beyond the usual suspects

Journal of Clinical Investigation

Volumn 116, Issue 6, 2006, Pages 1481-1483

  Mitchell, Aaron P ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; GLUCOSYLCERAMIDE; GLYCOSPHINGOLIPID;

ALKALINITY; BLOOD FLOW; CELL SURFACE; CRYPTOCOCCOSIS; CRYPTOCOCCUS; FUNGAL VIRULENCE; MACROPHAGE; NONHUMAN; PATHOGENICITY; PH; PRIORITY JOURNAL; REVIEW;

CARBON DIOXIDE; CRYPTOCOCCUS NEOFORMANS; GLUCOSYLCERAMIDES; HUMANS; HYDROGEN-ION CONCENTRATION; MACROPHAGES; MUTATION; PULMONARY ALVEOLI;

EID: 33745225218     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI28842     Document Type: Review

References (13)

1. Idnurm, A., et al. 2005. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nat. Rev. Microbiol. 3:753-764.
2. Rittershaus, P.C., et al. 2006. Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J. Clin. Invest. 116:1651-1659. doi:10.1172/JCI27890.
3. Fraser, J.A., et al. 2005. Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature. 437:1360-1364.
4. Kidd, S.E., et al. 2004. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc. Natl. Acad. Sci. U. S. A. 101:17258-17263.
5. Feldmesser, M., Tucker, S., and Casadevall, A. 2001. Intracellular parasitism of macrophages by Cryptococcus neoformans. Trends Microbiol. 9:273-278.
6. Bignell, E., et al. 2005. The Aspergillus pH-responsive transcription factor PacC regulates virulence. Mol. Microbiol. 55:1072-1084.
7. Davis, D. 2003. Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Curr. Genet. 44:1-7.
8. Fox, D.S., and Heitman, J. 2002. Good fungi gone bad: the corruption of calcineurin. Bioessays. 24:894-903.
9. Granger, D.L., Perfect, J.R., and Durack, D.T. 1985. Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide. J. Clin. Invest. 76:508-516.
10. Chen, Y., et al. 2000. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 289:625-628.
11. 2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. Eukaryot. Cell. 5:103-111.
12. Bahn, Y.S., Cox, G.M., Perfect, J.R., and Heitman, J. 2005. Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Curr. Biol. 15:2013-2020.
13. Rodrigues, M.L., et al. 2000. Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth. Infect. Immun. 68:7049-7060.