The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system

Infection and Immunity

Volumn 74, Issue 10, 2006, Pages 5977-5988

  Shea, John M ^a   Kechichian, Talar B ^a   Luberto, Chiara ^a   Del Poeta, Maurizio ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FUNGAL ENZYME; MEMBRANE ENZYME; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; SPHINGOLIPID;

ACIDIC STRESS; ACIDITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CRYPTOCOCCUS; CRYPTOCOCCUS NEOFORMANS; FEMALE; FUNGAL GENE; FUNGAL STRAIN; FUNGAL VIRULENCE; GENE ISOLATION; ICS1 GENE; INFECTION SENSITIVITY; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MENINGOENCEPHALITIS; MOUSE; NITROSATIVE STRESS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHAGOLYSOSOME; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; STRESS;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CRYPTOCOCCUS NEOFORMANS; FEMALE; GENE DELETION; LUNG; MACROPHAGES, ALVEOLAR; MENINGITIS, CRYPTOCOCCAL; MICE; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; PHAGOSOMES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; SPHINGOLIPIDS; TYPE C PHOSPHOLIPASES;

EID: 33749242244     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00768-06     Document Type: Article

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