Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: Implications for circuitry

Pain

Volumn 75, Issue 2-3, 1998, Pages 247-255

  Heinricher, M M ^a   McGaraughty, S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Descending control; Kynurenate; Microinjection; Nucleus raphe magnus; Opioid analgesia; Pain modulation

Indexed keywords

EXCITATORY AMINO ACID; KYNURENIC ACID; OPIATE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MODULATION; NEUROTRANSMISSION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; TAIL FLICK TEST;

ANIMALS; BIOLOGICAL TRANSPORT; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACIDS; KYNURENIC ACID; MALE; MEDULLA OBLONGATA; NEURAL PATHWAYS; NEURONS; NOCICEPTORS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME;

EID: 0031924039     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00226-1     Document Type: Article

References (40)

1. Aimone L.D., Gebhart G.F. Stimulation-produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid neurotransmitter in the medial medulla. J. Neurosci. 6:1986;1803-1813.
2. Barbaro N.M., Heinricher M.M., Fields H.L. Putative nociceptive modulatory neurons in the rostral ventromedial medulla of the rat display highly correlated firing patterns. Somatosen. Mot. Res. 6:1989;413-425.
3. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 7:1984;309-338.
4. Bederson J.B., Fields H.L., Barbaro N.M. Hyperalgesia during naloxone-precipitated withdrawal from morphine is associated with increased on-cell activity in the rostral ventromedial medulla. Somatosen. Mot. Res. 7:1990;185-203.
5. Besson J.M., Chaouch A. Peripheral and spinal mechanisms of nociception. Physiol. Rev. 67:1987;67-186.
6. Cohen G.A., Doze V.A., Madison D.V. Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons. Neuron. 9:1992;325-335.
7. Collingridge G.L., Lester R.A. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 41:1989;143-210.
8. Duggan A.W., North R.A. Electrophysiology of opioids. Pharmacol. Rev. 35:1983;219-281.
9. Fields H.L., Bry J., Hentall I., Zorman G. The activity of neurons in the rostral medulla of the rat during withdrawal from noxious heat. J. Neurosci. 3:1983;2545-2552.
10. Fields H.L., Heinricher M.M. Anatomy and physiology of a nociceptive modulatory system. Philos. Trans. R. Soc. Lond. B. 308:1985;361-374.
11. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1991;219-245.
12. Heinricher M.M., Barbaro N.M., Fields H.L. Putative nociceptive modulating neurons in the rostral ventromedial medulla of the rat: firing of on- and off-cells is related to nociceptive responsiveness. Somatosen. Mot. Res. 6:1989;427-439.
13. Heinricher M.M., Haws C.M., Fields H.L. Evidence for GABA-mediated control of putative nociceptive modulating neurons in the rostral ventromedial medulla: iontophoresis of bicuculline eliminates the off-cell pause. Somatosen. Mot. Res. 8:1991;215-225.
14. Heinricher M.M., Morgan M.M., Fields H.L. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience. 48:1992;533-543.
15. Heinricher M.M., Morgan M.M., Tortorici V., Fields H.L. Disinhibition of off-cells and antinociception produced by an opioid action within the rostral ventromedial medulla. Neuroscience. 63:1994;279-288.
16. Heinricher M.M., Roychowdhury S. Reflex-related activation of putative pain facilitating neurons in rostral ventromedial medulla (RVM) depends upon excitatory amino acid transmission. Neuroscience. 78:1997;1159-1165.
17. Heinricher M.M., Tortorici V. Interference with GABA transmission in the rostral ventromedial medulla: disinhibition of off-cells as a central mechanism in nociceptive modulation. Neuroscience. 63:1994;533-546.
18. Jensen T.S., Yaksh T.L. Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats. Brain Res. 476:1989;1-9.
19. Jensen T.S., Yaksh T.L. The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis. Brain Res. 569:1992;255-267.
20. Jensen T.S., Yaksh T.L. Brainstem excitatory amino acid receptors in nociception: microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior. Neuroscience. 46:1992;535-547.
21. Kaplan H., Fields H.L. Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla. J. Neurosci. 11:1991;1433-1439.
22. Lambert N.A., Harrison N.L., Teyler T.J. Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus. Neurosci. Lett. 124:1991;101-104.
23. Lovick T.A. Ventrolateral medullary lesions block the antinociceptive and cardiovascular responses elicited by stimulating the dorsal periaqueductal grey matter in rats. Pain. 21:1985;241-252.
24. Mason P., Fields H.L. Axonal trajectories and terminations of on- and off-cells in the cat lower brainstem. J. Comp. Neurol. 288:1989;185-207.
25. Mayer M.L., Westbrook G.L. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28:1987;197-276.
26. Morgan M.M., Fields H.L. Pronounced changes in the activity of nociceptive modulatory neurons in the rostral ventromedial medulla in response to prolonged thermal noxious stimuli. J. Neurophysiol. 72:1994;1161-1170.
27. Nicoll R.A., Malenka R.C., Kauer J.A. Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol. Rev. 70:1990;513-565.
28. Pan Z.Z., Williams J.T., Osborne P.B. Opioid actions on single nucleus raphe magnus neurons from rat and guinea-pig in vitro. J. Physiol. 427:1990;519-532.
29. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, 1997.
30. Proudfit, H.K., Effects of raphe magnus and raphe pallidus lesions on morphine-induced analgesia and spinal cord monoamines, Pharmacol. Biochem. Behav., 13 (1980a) 705-714.
31. Proudfit, H.K., Reversible inactivation of raphe magnus neurons: effects on nociceptive threshold and morphine-induced analgesia, Brain Res., 201 (1980) 459-464.
32. Randich A., Thurston C.L., Ludwig P.S., Robertson J.D., Rasmussen C. Intravenous morphine-induced activation of vagal afferents: peripheral, spinal, and CNS substrates mediating inhibition of spinal nociception and cardiovascular responses. J. Neurophysiol. 68:1992;1027-1045.
33. Rekling J.C. Effects of met-enkephalin on GABAergic spontaneous miniature IPSPs in organotypic slice cultures of the rat hippocampus. J. Neurosci. 13:1993;1954-1964.
34. Richter R.C., Behbehani M.M. Evidence for glutamic acid as a possible neurotransmitter between the mesencephalic nucleus cuneiformis and the medullary nucleus raphe magnus in the lightly anesthetized rat. Brain Res. 544:1991;279-286.
35. Spinella M., Cooper M.L., Bodnar R.J. Excitatory amino acid antagonists in the rostral ventromedial medulla inhibit mesencephalic morphine analgesia in rats. Pain. 64:1996;545-552.
36. Stone T.W. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45:1993;309-379.
37. Watkins J.C., Evans R.H. Excitatory amino acid transmitters. Annu. Rev. Pharmacol. Toxicol. 21:1981;165-204.
38. Watkins L.R., Wiertelak E.P., Goehler L.E., Mooney-Heiberger K., Martinez J., Furness L., Smith K.P., Maier S.F. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 639:1994;283-299.
39. Wiertelak E.P., Roemer B., Maier S.F., Watkins L.R. Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. Brain Res. 748:1997;143-150.
40. Young E.G., Watkins L.R., Mayer D.J. Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesia. Brain Res. 290:1984;119-129.