Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C- and N-terminally truncated fragments of parathyroid hormone 1-34

Journal of Bone and Mineral Research

Volumn 16, Issue 3, 2001, Pages 441-447

  Whitfield, J F ^a   Isaacs, R J ^a   Chakravarthy, B ^a   Maclean, S ^a   Morley, P ^a   Willick, G ^a   Divieti, P ^b   Bringhurst, F R ^b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Adenylyl cyclase; Parathyroid hormone; Protein kinase C; Receptors

Indexed keywords

ADENYLATE CYCLASE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PHOSPHOLIPASE C; PROTEIN KINASE C;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PHOSPHOLIPASE C; PROTEIN KINASE C; RECEPTORS, PARATHYROID HORMONE; SKIN; SWINE;

EID: 0035105034     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.3.441     Document Type: Article

References (38)

1. The parathyroid hormone, its fragments and analogs - Potent bone builders for treating osteoporosis
2. The protein kinase-C activation domain of the parathyroid hormone
3. Further definition of the protein kinase C activation domain of the parathyroid hormone
4. 2 to stimulate bone growth in ovariectomized rats
5. 2
6. Differential effects of parathyroid hormone and its analogues on cytosolic calcium ions and cAMP levels in cultured rat osteoblast-like cells
7. Stucture-function relationship of parathyroid hormone: Activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells
8. + exchanger NH3 isoform by binding to the PTH/PTHrP receptor type 1 and activating distinct signaling pathways
9. Cell-specific signaling and structure-activity relations of parathyroid hormone analogs in mouse kidney cells
10. In vivo anabolic effects of parathyroid hormone ('PTH) 28-48 and N-terminal fragments of PTH and PTH-related protein on neonatal mouse bones
11. + exchanger NHE-3 isoform in renal cells (OK) via a dual signaling cascade involving protein kinase A and C
12. Parathyroid hormone stimulates ecto-5 78-nucleotidase activity in renal epithelial cells: Role of protein kinase-C
13. 1 co-transporter
14. Type-1 parathyroid hormone (PTH/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH
15. Dual signaling and ligand selectivity of the human PTH/PTHrP receptor
16. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 receptor: Implications for design of signal-specific PTH ligands
17. Parathyroid hormone and glucagons compete for binding to low affinity sites on human skin fibroblasts
18. Cultured human fibroblasts and not cultured human keratinocytes express a PTH/PTHrP receptor mRNA
19. Identification and characterization of parathyroid hormone receptors on dog kidney, human kidney, chick bone and human dermal fibroblast. A comparative study of functional and structural properties
20. Parathyroid hormone-activated phosphoinositide degradation and calcium channels in human dermal fibroblasts
21. A factor produced by cultured rat leydig tumor (Rice-500) cells associated with humoral hypercalcemia stimulates adenosine 3',5'-monophosphate production via the parathyroid hormone receptor in human skin fibroblasts
22. Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins
23. Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: Cyclic lactams of the receptor-binding region
24. The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate
25. Inactive membrane protein kinase Cs: A possible target for receptor signalling
26. Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes
27. TIP: A new neuropeptide and PTH2-receptor agonist from hypothalamus
28. PTH and P42/P44 activation in OK cells and LLC-PK1 cells expressing differential densities of human PTH1 receptor (PTHR1)
29. 2
30. Parathyroid hormone regulates transforming growth factor β1 and β2 synthesis in osteoblasts via divergent signaling pathways
31. 2
32. +-ATPase through a cytochrome P-450 pathway
33. Parathyroid hormone (PTH)-(1-34), [Nle(8,18), Tyr34]PTH-(3-34)amide, and PTH-related peptide-(1-34) stimulate phosphatidylcholine hydrolysis in UMR-106 osteoblastic cells: Comparison with effects of phorbol 12,13-dibutyrate
34. Activation of phospholipase D by transfected PTH/PTHrP receptors in LLCPK1 cells
35. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase
36. 2 and hPTH-(1-34) in healthy humans
37. Comparison of bone formation responses to parathyroid hormone (1-34), (1-31) and (2-34) in mice