Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues

European Journal of Endocrinology

Volumn 162, Issue 5, 2010, Pages 979-986

  Lupp, Amelie ^a   Klenk, Christoph ^b   Röcken, Christoph ^c   Evert, Matthias ^d   Mawrin, Christian ^e   Schulz, Stefan ^a,b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE ANTIBODY; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE RECEPTOR 1 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; ASTROCYTOMA; BREAST CARCINOMA; CARBOXY TERMINAL SEQUENCE; CARCINOID; CELL MEMBRANE; CHO CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENDOMETRIOSIS; FEMALE; GLIOBLASTOMA; GLOMERULUS; HENLE LOOP; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY CARCINOMA; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY EPITHELIUM; KIDNEY TUBULE CELL; MALE; MELANOMA; NEOPLASM; NONHUMAN; OSTEOBLAST; OSTEOCYTE; OSTEOSARCOMA; OVARY CARCINOMA; PANCREAS ADENOCARCINOMA; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROTEIN EXPRESSION; UTERINE CERVIX CANCER; UTERUS CARCINOMA; WESTERN BLOTTING;

ANIMALS; BONE AND BONES; CARCINOMA, RENAL CELL; CHO CELLS; COLORECTAL NEOPLASMS; CRICETINAE; CRICETULUS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINES; KIDNEY; MALE; OSTEOSARCOMA; PROSTATIC NEOPLASMS; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

EID: 77951654497     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0821     Document Type: Article

References (42)

1. Gensure RC, Gardella TJ & Jüppner H. Parathyroid hormone and parathyroid hormone-related peptide, and their receptors. Biochemical and Biophysical Research Communications 2005 328 666-678. (Pubitemid 40208304)
2. Bacic D, Lehir M, Biber J, Kaissling B, Murer H & Wagner CA. The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney International 2006 69 495-503. (Pubitemid 43164441)
3. Philbrick WM, Wysolmersli JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE & Stewart AF. Defining the roles of the parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996 76 127-173. (Pubitemid 26048280)
4. Strewler GJ. The physiology of parathyroid hormone-related protein. New England Journal of Medicine 2000 342 177-185.
5. Birch MA, Carron JA, Scott M, Fraser WD & Gallagher JA. Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines. British Journal of Cancer 1995 72 90-96.
6. Guise TA, Yin JJ, Taylor SD, Kumagi Y, Dallas M, Boyce BF, Yoneda T & Mundy GR. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. Journal of Clinical Investigation 1996 98 1544-1549. (Pubitemid 26327863)
7. Dougherty KM, Blomme EAG, Koh AJ, Henderson JE, Pienta KJ, Rosol TJ & McCauley LK. Parathyroid hormone-related protein as a growth regulator of prostate carcinoma. Cancer Research 1999 59 6015-6022. (Pubitemid 30004967)
8. Kunisada T, Moseley JM, Slavin JL, Martin TJ & Choong PF. Co-expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in cartilaginous tumours: a marker for malignancy? Pathology 2002 34 133-137.
9. Linforth R, Anderson N, Hoey R, Nolan T, Downey S, Brady G, Ashcroft L & Bundred N. Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival. Clinical Cancer Research 2002 8 3172-3177. (Pubitemid 35155027)
10. Tovar-Sepulveda VA & Falzon M. Parathyroid hormone-related protein enhances PC-3 prostate cancer cell growth via both autocrine/paracrine and intracrine pathways. Regulatory Peptides 2002 105 109-120. (Pubitemid 34219392)
11. Massfelder T, Lang H, Schordan E, Lindner V, Rothhut S, Welsch S, Simon-Assmann P, Barthelmebs M, Jacqmin D & Helwig JJ. Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the Von Hippel-Lindau tumor suppressor gene. Cancer Research 2004 64 180-188. (Pubitemid 38114096)
12. Deftos LJ, Barken I, Burton DW, Hoffman RM & Geller J. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochemical and Biophysical Research Communications 2005 327 468-472. (Pubitemid 40040499)
13. Perez-Martinez FC, Alonso V, Sarasa JL, Nam-Cha SG, Vela-Navarrete R, Manzarbeitia F, Calahorra FJ & Esbrit P. Immunohistochemical analysis of low-grade and high-grade prostate carcinoma: relative changes of parathyroid hormone-related protein and its parathyroid hormone 1 receptor, osteoprotegerin and receptor activator of nuclear factor-kB ligand. Journal of Clinical Pathology 2007 60 290-294. (Pubitemid 46447745)
14. Schipani E, Lanske B, Hunzelman J, Kovacs CS, Lee K, Pirro A, Kronenberg HM & Jüppner H. Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid-hormone- related peptide. PNAS 1997 94 13689-13694.
15. Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE & Philbrick WM. Regulation of epidermal differentiation by PTHrP: evidence from PTHrP-null and PTHrP-overexpressing mice. Journal of Investigative Dermatology 1998 111 1122-1128.
16. Philbrick WM, Dreyer BE, Nakchbandi IA & Karaplis AC. Parathyroid hormone-related protein is required for tooth eruption. PNAS 1998 95 11846-11851.
17. Wysolmerski JJ, Philbrick WM, Dunbar ME, Lanske B, Kronenberg H & Broadus AE. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998 125 1285-1294.
18. Kronenberg HM. Developmental regulation of the growth plate. Nature 2003 423 332-336.
19. Jüppner H, Abou-Samra A, Freeman MW, Kong XF, Schipani E, Richards J, Kolakowski LF, Hock J, Potts JT, Kronenberg HM & Segre GV. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991 254 1024-1026.
20. Usdin TB, Gruber C & Bonner TI. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. Journal of Biological Chemistry 1995 270 15455-15458.
21. Carron JA, Fraser WD & Gallagher JA. PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours. British Journal of Cancer 1997 76 1095-1098.
22. Iddon J, Bundred NJ, Hoyland J, Downey SE, Baird P, Salter D, McMahon R & Freemont AJ. Expression of parathyroid hormone-related protein and its receptor in bone metastases from prostate cancer. Journal of Pathology 2000 191 170-174.
23. Hoey RP, Sanderson C, Iddon J, Brady G, Bundred NJ & Anderson NG. The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. British Journal of Cancer 2003 88 567-573.
24. Yang R, Hoang BH, Kubo T, Kawano H, Chou A, Sowers R, Huvos AG, Meyers PA, Healey JH & Gorlick R. Over-expression of parathyroid hormone type 1 receptor confers an aggressive phenotype in osteosarcoma. International Journal of Cancer 2007 121 943-954.
25. Nakashima M, Nakayama T, Ohtsuru A, Fukada E, Niino D, Yamazumi K, Naito S, Ito M & Sekine I. Expression of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor in osteoclast-like giant cells. Pathology, Research and Practice 2003 199 85-92.
26. Ohtsuru M. Expression of parathyroid hormone-related protein in ameloblastomas. Tokai Journal of Experimental and Clinical Medicine 2005 30 233-239.
27. Gessi M, Monego G, Calviello G, Lanza P, Giangaspero F, Silvestrini A, Lauriola L & Ranelletti FO. Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines. Acta Neuropathologica 2007 114 135-145.
28. Iezzoni JC, Bruns ME, Frierson HF, Scott MG, Pence MA, Deftos LJ & Bruns DE. Coexpression of parathyroid hormone-related protein and its receptor in breast carcinoma: a potential autocrine effector system. Modern Pathology 1998 11 265-270.
29. Suzuki Y, Tokuda Y, Saito Y, Umemura S & Osamura RY. Clinicopathological correlation between expression of PTHrP receptor and various prognostic factors in breast cancer without axillary lymph node metastasis. Tokai Journal of Experimental and Clinical Medicine 2005 30 127-132.
30. Ito M, Nakashima M, Alipov GK, Matsuzaki S, Ohtsuru A, Yano H, Yamashita S & Sekine I. Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression. Journal of Gastroenterology 1997 32 396-400.
31. Schulz S, Pauli SU, Handel M, Dietzmann K, Firsching U & Höllt V. Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A. Clinical Cancer Research 2000 6 1865-1974.
32. Schulz S, Stumm R & Höllt V. Immunofluorescent identification of neuropeptide B-containing nerve fibers and terminals in the rat hypothalamus. Neuroscience Letters 2007 411 67-71.
33. Castro M, Dicker F, Vilardaga JP, Krasel C, Bernhardt M & Lohse MJ. Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology 2002 143 3854-3865.
34. Lupp A, Danz M & Müller D. Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices. Toxicology 2001 161 53-66.
35. Lagger Biner H, Arpin-Bott MP, Loffing J, Wang X, Knepper M, Hebert SC & Kaissling B. Human cortical distal nephron: distribution of electrolyte and water transport pathways. Journal of the American Society of Nephrology 2002 13 836-847.
36. Devuyst O, Dahan K & Pirson Y. Tamm-Horsfall protein or uromodulin: new ideas about an old molecule. Nephrology, Dialysis, Transplantation 2005 20 1290-1294.
37. Agre P. Aquaporin water channels in kidney. Journal of the American Society of Nephrology 2000 11 764-777.
38. Ichikawa I, Humes HD, Dousa TP & Brenner BM. Influence of parathyroid hormone on glomerular ultrafiltration in the rat. American Journal of Physiology 1978 234 F393-F401.
39. Divieti PP. PTH and osteocytes. Journal of Musculoskeletal & Neuronal Interactions 2005 5 328-330.
40. Dempster DW, Hughes-Begos CE, Plavetic-Chee K, Brandao-Burch A, Cosman F, Nieves J, Neubort S, Lu SS, Iida-Klein A, Arnett T & Lindsay R. Normal human osteoclasts from peripheral blood monocytes express PTH type 1 receptors and are stimulated by PTH in the absence of osteoblasts. Cell Biochemistry 2005 95 139-148.
41. Fermor B & Skerry TM. PTH/PTHrP receptor expression on osteoblasts and osteocytes but not resorbing bone surfaces in growing rats. Journal of Bone and Mineral Research 1995 10 1935-1943.
42. Lasukova TV. Enkephalin blockade of the stimulating effect of parathormone on adrenal cortex function. Fiziologicheskii Zhurnal SSSR 1990 76 402-405.