-
1
-
-
58149335251
-
Learning from molecular genetics: Novel insights arising from the definition of genes for monogenic and type 2 diabetes
-
1:CAS:528:DC%2BD1MXhsleju74%3D 10.2337/db08-0343 18971436
-
MI McCarthy AT Hattersley 2008 Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes Diabetes 57 2889 2898 1:CAS:528:DC%2BD1MXhsleju74%3D 10.2337/db08-0343 18971436
-
(2008)
Diabetes
, vol.57
, pp. 2889-2898
-
-
McCarthy, M.I.1
Hattersley, A.T.2
-
2
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
1:CAS:528:DC%2BD2sXhvFGiurw%3D 10.1038/nature05616 17293876
-
R Sladek G Rocheleau J Rung C Dina L Shen D Serre P Boutin D Vincent A Belisle S Hadjadj, et al. 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881 885 1:CAS:528:DC%2BD2sXhvFGiurw%3D 10.1038/nature05616 17293876
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
Dina, C.4
Shen, L.5
Serre, D.6
Boutin, P.7
Vincent, D.8
Belisle, A.9
Hadjadj, S.10
-
3
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
1:CAS:528:DC%2BD2sXmtVyitrk%3D 10.1126/science.1142358 17463246
-
R Saxena BF Voight V Lyssenko NP Burtt PI de Bakker H Chen JJ Roix S Kathiresan JN Hirschhorn MJ Daly, et al. 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 1:CAS:528:DC%2BD2sXmtVyitrk%3D 10.1126/science.1142358 17463246
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
De Bakker, P.I.5
Chen, H.6
Roix, J.J.7
Kathiresan, S.8
Hirschhorn, J.N.9
Daly, M.J.10
-
4
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
1:CAS:528:DC%2BD2sXmtVymtb0%3D 10.1126/science.1142364 17463249
-
E Zeggini MN Weedon CM Lindgren TM Frayling KS Elliott H Lango NJ Timpson JR Perry NW Rayner RM Freathy, et al. 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341 1:CAS:528:DC%2BD2sXmtVymtb0%3D 10.1126/science.1142364 17463249
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
Timpson, N.J.7
Perry, J.R.8
Rayner, N.W.9
Freathy, R.M.10
-
5
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
-
1:CAS:528:DC%2BD2sXmtVyitrY%3D 10.1126/science.1142382 17463248
-
LJ Scott KL Mohlke LL Bonnycastle CJ Willer Y Li WL Duren MR Erdos HM Stringham PS Chines AU Jackson, et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345 1:CAS:528:DC%2BD2sXmtVyitrY%3D 10.1126/science.1142382 17463248
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
Erdos, M.R.7
Stringham, H.M.8
Chines, P.S.9
Jackson, A.U.10
-
6
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
1:CAS:528:DC%2BD1cXltFylurY%3D 10.1038/ng.120 18372903
-
E Zeggini LJ Scott R Saxena BF Voight JL Marchini T Hu PI de Bakker GR Abecasis P Almgren G Andersen, et al. 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645 1:CAS:528:DC%2BD1cXltFylurY%3D 10.1038/ng.120 18372903
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
Marchini, J.L.5
Hu, T.6
De Bakker, P.I.7
Abecasis, G.R.8
Almgren, P.9
Andersen, G.10
-
7
-
-
58149333712
-
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: A population-based study
-
10.2337/db08-0425 18694974
-
M van Hoek A Dehghan JC Witteman CM van Duijn AG Uitterlinden BA Oostra A Hofman EJ Sijbrands AC Janssens 2008 Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study Diabetes 57 3122 3128 10.2337/db08-0425 18694974
-
(2008)
Diabetes
, vol.57
, pp. 3122-3128
-
-
Van Hoek, M.1
Dehghan, A.2
Witteman, J.C.3
Van Duijn, C.M.4
Uitterlinden, A.G.5
Oostra, B.A.6
Hofman, A.7
Sijbrands, E.J.8
Janssens, A.C.9
-
8
-
-
50449085212
-
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
-
1:CAS:528:DC%2BD1cXhtVGgt77E 10.1038/ng.208 18711366
-
H Unoki A Takahashi T Kawaguchi K Hara M Horikoshi G Andersen DP Ng J Holmkvist K Borch-Johnsen T Jorgensen, et al. 2008 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat Genet 40 1098 1102 1:CAS:528:DC%2BD1cXhtVGgt77E 10.1038/ng.208 18711366
-
(2008)
Nat Genet
, vol.40
, pp. 1098-1102
-
-
Unoki, H.1
Takahashi, A.2
Kawaguchi, T.3
Hara, K.4
Horikoshi, M.5
Andersen, G.6
Ng, D.P.7
Holmkvist, J.8
Borch-Johnsen, K.9
Jorgensen, T.10
-
9
-
-
50449085998
-
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
-
1:CAS:528:DC%2BD1cXhtVGgt77M 10.1038/ng.207 18711367
-
K Yasuda K Miyake Y Horikawa K Hara H Osawa H Furuta Y Hirota H Mori A Jonsson Y Sato, et al. 2008 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat Genet 40 1092 1097 1:CAS:528:DC%2BD1cXhtVGgt77M 10.1038/ng.207 18711367
-
(2008)
Nat Genet
, vol.40
, pp. 1092-1097
-
-
Yasuda, K.1
Miyake, K.2
Horikawa, Y.3
Hara, K.4
Osawa, H.5
Furuta, H.6
Hirota, Y.7
Mori, H.8
Jonsson, A.9
Sato, Y.10
-
10
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
1:CAS:528:DC%2BC3cXntVCksw%3D%3D 10.1038/ng.521 20081857
-
R Saxena MF Hivert C Langenberg T Tanaka JS Pankow P Vollenweider V Lyssenko N Bouatia-Naji J Dupuis AU Jackson, et al. 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 42 142 148 1:CAS:528:DC%2BC3cXntVCksw%3D%3D 10.1038/ng.521 20081857
-
(2010)
Nat Genet
, vol.42
, pp. 142-148
-
-
Saxena, R.1
Hivert, M.F.2
Langenberg, C.3
Tanaka, T.4
Pankow, J.S.5
Vollenweider, P.6
Lyssenko, V.7
Bouatia-Naji, N.8
Dupuis, J.9
Jackson, A.U.10
-
11
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 10.1038/ng.520 20081858
-
J Dupuis C Langenberg I Prokopenko R Saxena N Soranzo AU Jackson E Wheeler NL Glazer N Bouatia-Naji AL Gloyn, et al. 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105 116 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 10.1038/ng.520 20081858
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
Saxena, R.4
Soranzo, N.5
Jackson, A.U.6
Wheeler, E.7
Glazer, N.L.8
Bouatia-Naji, N.9
Gloyn, A.L.10
-
12
-
-
77951858557
-
Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans
-
1:CAS:528:DC%2BC3cXmtFegtrk%3D 10.2337/db09-1568 20185807
-
E Ingelsson C Langenberg MF Hivert I Prokopenko V Lyssenko J Dupuis R Magi S Sharp AU Jackson TL Assimes, et al. 2010 Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans Diabetes 59 1266 1275 1:CAS:528:DC%2BC3cXmtFegtrk%3D 10.2337/db09-1568 20185807
-
(2010)
Diabetes
, vol.59
, pp. 1266-1275
-
-
Ingelsson, E.1
Langenberg, C.2
Hivert, M.F.3
Prokopenko, I.4
Lyssenko, V.5
Dupuis, J.6
Magi, R.7
Sharp, S.8
Jackson, A.U.9
Assimes, T.L.10
-
13
-
-
77954172286
-
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
-
1:CAS:528:DC%2BC3cXntlCquro%3D 10.1093/hmg/ddq156 20418489
-
L Qi MC Cornelis P Kraft KJ Stanya WH Kao JS Pankow J Dupuis JC Florez CS Fox G Pare, et al. 2010 Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes Hum Mol Genet 19 2706 2715 1:CAS:528:DC%2BC3cXntlCquro%3D 10.1093/hmg/ddq156 20418489
-
(2010)
Hum Mol Genet
, vol.19
, pp. 2706-2715
-
-
Qi, L.1
Cornelis, M.C.2
Kraft, P.3
Stanya, K.J.4
Kao, W.H.5
Pankow, J.S.6
Dupuis, J.7
Florez, J.C.8
Fox, C.S.9
Pare, G.10
-
14
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
1:CAS:528:DC%2BC3cXnvFykt70%3D 10.1038/ng.609 20581827
-
BF Voight LJ Scott V Steinthorsdottir AP Morris C Dina RP Welch E Zeggini C Huth YS Aulchenko G Thorleifsson, et al. 2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis Nat Genet 42 579 589 1:CAS:528:DC%2BC3cXnvFykt70%3D 10.1038/ng.609 20581827
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
Morris, A.P.4
Dina, C.5
Welch, R.P.6
Zeggini, E.7
Huth, C.8
Aulchenko, Y.S.9
Thorleifsson, G.10
-
15
-
-
57349103144
-
Clinical review: The genetics of type 2 diabetes: A realistic appraisal in 2008
-
1:CAS:528:DC%2BD1cXhsVyqtb3O 10.1210/jc.2008-1345 18782870
-
JC Florez 2008 Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008 J Clin Endocrinol Metab 93 4633 4642 1:CAS:528:DC%2BD1cXhsVyqtb3O 10.1210/jc.2008-1345 18782870
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 4633-4642
-
-
Florez, J.C.1
-
16
-
-
33645983221
-
LXRS and FXR: The yin and yang of cholesterol and fat metabolism
-
1:CAS:528:DC%2BD28XksFWksrs%3D 10.1146/annurev.physiol.68.033104.152158 16460270
-
NY Kalaany DJ Mangelsdorf 2006 LXRS and FXR: the yin and yang of cholesterol and fat metabolism Annu Rev Physiol 68 159 191 1:CAS:528: DC%2BD28XksFWksrs%3D 10.1146/annurev.physiol.68.033104.152158 16460270
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 159-191
-
-
Kalaany, N.Y.1
Mangelsdorf, D.J.2
-
17
-
-
9444296497
-
Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells
-
1:CAS:528:DC%2BD2cXhtVOls73I 10.2337/diabetes.53.suppl-3.S75 15561926
-
AM Efanov S Sewing K Bokvist J Gromada 2004 Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells Diabetes 53 Suppl 3 S75 S78 1:CAS:528:DC%2BD2cXhtVOls73I 10.2337/diabetes.53.suppl-3.S75 15561926
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Efanov, A.M.1
Sewing, S.2
Bokvist, K.3
Gromada, J.4
-
18
-
-
0345461478
-
Putative metabolic effects of the liver X receptor (LXR)
-
1:CAS:528:DC%2BD2cXhtlGqsLc%3D 10.2337/diabetes.53.2007.S36 14749264
-
KR Steffensen JA Gustafsson 2004 Putative metabolic effects of the liver X receptor (LXR) Diabetes 53 Suppl 1 S36 S42 1:CAS:528:DC%2BD2cXhtlGqsLc%3D 10.2337/diabetes.53.2007.S36 14749264
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 1
-
-
Steffensen, K.R.1
Gustafsson, J.A.2
-
19
-
-
0037428442
-
Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis
-
1:CAS:528:DC%2BD3sXnsl2k 10.1074/jbc.M210208200 12414791
-
G Cao Y Liang CL Broderick BA Oldham TP Beyer RJ Schmidt Y Zhang KR Stayrook C Suen KA Otto, et al. 2003 Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis J Biol Chem 278 1131 1136 1:CAS:528:DC%2BD3sXnsl2k 10.1074/jbc.M210208200 12414791
-
(2003)
J Biol Chem
, vol.278
, pp. 1131-1136
-
-
Cao, G.1
Liang, Y.2
Broderick, C.L.3
Oldham, B.A.4
Beyer, T.P.5
Schmidt, R.J.6
Zhang, Y.7
Stayrook, K.R.8
Suen, C.9
Otto, K.A.10
-
20
-
-
0037965630
-
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
-
1:CAS:528:DC%2BD3sXjs1yitb4%3D 10.1073/pnas.0830671100 12697904
-
BA Laffitte LC Chao J Li R Walczak S Hummasti SB Joseph A Castrillo DC Wilpitz DJ Mangelsdorf JL Collins, et al. 2003 Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proc Natl Acad Sci USA 100 5419 5424 1:CAS:528:DC%2BD3sXjs1yitb4%3D 10.1073/pnas.0830671100 12697904
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5419-5424
-
-
Laffitte, B.A.1
Chao, L.C.2
Li, J.3
Walczak, R.4
Hummasti, S.5
Joseph, S.B.6
Castrillo, A.7
Wilpitz, D.C.8
Mangelsdorf, D.J.9
Collins, J.L.10
-
21
-
-
25444512015
-
Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice
-
1:CAS:528:DC%2BD2MXht1CntrfI 10.1152/ajpendo.00165.2005 15941783
-
A Grefhorst TH van Dijk A Hammer FH van der Sluijs R Havinga LM Havekes JA Romijn PH Groot DJ Reijngoud F Kuipers 2005 Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice Am J Physiol Endocrinol Metab 289 E829 E838 1:CAS:528:DC%2BD2MXht1CntrfI 10.1152/ajpendo.00165.2005 15941783
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Grefhorst, A.1
Van Dijk, T.H.2
Hammer, A.3
Van Der Sluijs, F.H.4
Havinga, R.5
Havekes, L.M.6
Romijn, J.A.7
Groot, P.H.8
Reijngoud, D.J.9
Kuipers, F.10
-
22
-
-
20844459611
-
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function
-
1:CAS:528:DC%2BD2MXltVyhtb0%3D 10.1074/jbc.M412564200 15831500
-
I Gerin VW Dolinsky JG Shackman RT Kennedy SH Chiang CF Burant KR Steffensen JA Gustafsson OA MacDougald 2005 LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function J Biol Chem 280 23024 23031 1:CAS:528:DC%2BD2MXltVyhtb0%3D 10.1074/jbc.M412564200 15831500
-
(2005)
J Biol Chem
, vol.280
, pp. 23024-23031
-
-
Gerin, I.1
Dolinsky, V.W.2
Shackman, J.G.3
Kennedy, R.T.4
Chiang, S.H.5
Burant, C.F.6
Steffensen, K.R.7
Gustafsson, J.A.8
MacDougald, O.A.9
-
23
-
-
57249094223
-
Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
-
1:CAS:528:DC%2BD1cXhsVCmsrfO 10.1007/s00125-008-1174-x 18949453
-
ZX Meng J Nie JJ Ling JX Sun YX Zhu L Gao JH Lv DY Zhu YJ Sun X Han 2009 Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest Diabetologia 52 125 135 1:CAS:528:DC%2BD1cXhsVCmsrfO 10.1007/s00125-008-1174-x 18949453
-
(2009)
Diabetologia
, vol.52
, pp. 125-135
-
-
Meng, Z.X.1
Nie, J.2
Ling, J.J.3
Sun, J.X.4
Zhu, Y.X.5
Gao, L.6
Lv, J.H.7
Zhu, D.Y.8
Sun, Y.J.9
Han, X.10
-
24
-
-
34249682775
-
Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: Liver X receptor-mediated lipotoxicity in pancreatic beta-cells
-
1:CAS:528:DC%2BD2sXmtlKiu7c%3D 10.2337/db06-1059 17369526
-
SS Choe AH Choi JW Lee KH Kim JJ Chung J Park KM Lee KG Park IK Lee JB Kim 2007 Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells Diabetes 56 1534 1543 1:CAS:528:DC%2BD2sXmtlKiu7c%3D 10.2337/db06-1059 17369526
-
(2007)
Diabetes
, vol.56
, pp. 1534-1543
-
-
Choe, S.S.1
Choi, A.H.2
Lee, J.W.3
Kim, K.H.4
Chung, J.J.5
Park, J.6
Lee, K.M.7
Park, K.G.8
Lee, I.K.9
Kim, J.B.10
-
25
-
-
79959503826
-
-
The International HapMap Project. 10.1038/nature02168
-
The International HapMap Project 2003 Nature 426 789 796 10.1038/nature02168
-
(2003)
Nature
, vol.426
, pp. 789-796
-
-
-
26
-
-
27744492082
-
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
-
1:CAS:528:DC%2BD2MXht1Skt7vI 10.1007/s00125-005-1948-3 16205883
-
N Stefan F Machicao H Staiger J Machann F Schick O Tschritter C Spieth C Weigert A Fritsche M Stumvoll, et al. 2005 Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat Diabetologia 48 2282 2291 1:CAS:528:DC%2BD2MXht1Skt7vI 10.1007/s00125-005-1948- 3 16205883
-
(2005)
Diabetologia
, vol.48
, pp. 2282-2291
-
-
Stefan, N.1
MacHicao, F.2
Staiger, H.3
MacHann, J.4
Schick, F.5
Tschritter, O.6
Spieth, C.7
Weigert, C.8
Fritsche, A.9
Stumvoll, M.10
-
27
-
-
0036315001
-
Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans
-
1:CAS:528:DC%2BD38XhtVaqsbY%3D 10.2337/diabetes.51.2007.S234 11815485
-
A Fritsche A Madaus N Stefan O Tschritter E Maerker A Teigeler H Haring M Stumvoll 2002 Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans Diabetes 51 Suppl 1 S234 S239 1:CAS:528:DC%2BD38XhtVaqsbY%3D 10.2337/diabetes.51.2007.S234 11815485
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Fritsche, A.1
Madaus, A.2
Stefan, N.3
Tschritter, O.4
Maerker, E.5
Teigeler, A.6
Haring, H.7
Stumvoll, M.8
-
28
-
-
0030910313
-
MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase
-
1:CAS:528:DyaK2sXivF2ktr4%3D 10.1074/jbc.272.18.12069 9115275
-
AR Schievella JH Chen JR Graham LL Lin 1997 MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase J Biol Chem 272 12069 12075 1:CAS:528:DyaK2sXivF2ktr4%3D 10.1074/jbc.272.18.12069 9115275
-
(1997)
J Biol Chem
, vol.272
, pp. 12069-12075
-
-
Schievella, A.R.1
Chen, J.H.2
Graham, J.R.3
Lin, L.L.4
|