Solid-phase synthesis of siRNA oligonucleotides

Current Opinion in Drug Discovery and Development

Volumn 11, Issue 2, 2008, Pages 203-216

  Beaucage, Serge L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

2 Hydroxyl protection; Modified RNA oligonucleotide; Ribonucleoside phosphoramidite; RNA interference; siRNA; Solid phase synthesis

Indexed keywords

DOUBLE STRANDED RNA; HYDROXYL GROUP; MESSENGER RNA; OLIGONUCLEOTIDE; OLIGORIBONUCLEOTIDE; PHOSPHORAMIDOUS ACID; SMALL INTERFERING RNA;

CHEMICAL MODIFICATION; DERIVATIZATION; GENE EXPRESSION; GENE SILENCING; NONHUMAN; REVIEW; RNA INTERFERENCE; RNA STABILITY; RNA SYNTHESIS; SOLID PHASE SYNTHESIS; THERMOSTABILITY;

ANIMALS; HUMANS; INDICATORS AND REAGENTS; OLIGONUCLEOTIDES; RNA, SMALL INTERFERING;

EID: 39549113714     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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