Gene expression in primary cultured astrocytes affected by aluminum: Alteration of chaperons involved in protein folding

Environmental Health and Preventive Medicine

Volumn 16, Issue 1, 2011, Pages 16-24

  Aremu, David A ^a   Ezomo, Ojeiru F ^a   Meshitsuka, Shunsuke ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Aluminum; Astrocyte; ER resident molecular chaperons; ER stress; Unfolded protein response

Indexed keywords

ALUMINUM GLYCINATE; CALCIUM ION; CALNEXIN; CALRETICULIN; CELL PROTEIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; HYPOCALCIN; MITOCHONDRIAL RNA; OLD ASTROCYTE SPECIFICALLY INDUCED SUBSTANCE PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN IRE1; PROTEIN IRE1 ALPHA; PROTEIN IRE1 BETA; TUNICAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; MOUSE; NERVE CELL CULTURE; NONHUMAN; PROTEIN FOLDING; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; UPREGULATION;

ALUMINUM HYDROXIDE; ANIMALS; APOPTOSIS; ASTROCYTES; CELLS, CULTURED; DOWN-REGULATION; ENDOPLASMIC RETICULUM; ENDORIBONUCLEASES; GENE EXPRESSION REGULATION; GLYCINE; MICE; MOLECULAR CHAPERONES; PROTEIN FOLDING; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION; TUNICAMYCIN; UP-REGULATION;

EID: 78651229972     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1007/s12199-010-0161-2     Document Type: Article

References (72)

1. AS Lee 1992 Mammalian stress response: induction of the glucose-regulated protein family Curr Opin Cell Biol 4 267 273 1:CAS:528:DyaK38Xks1Ojtrs%3D 1599691 10.1016/0955-0674(92)90042-B
2. RJ Kaufman 1999 Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Genes Dev 13 1211 1233 1:CAS:528:DyaK1MXjslGjtbg%3D 10346810 10.1101/gad.13.10.1211
3. RR Kopito 2000 Aggresomes, inclusion bodies and protein aggregation Trends Cell Biol 10 524 530 1:CAS:528:DC%2BD3cXot12ltL0%3D 11121744 10.1016/S0962-8924(00)01852-3
4. RV Rao HM Ellerby DE Bredesen 2004 Coupling endoplasmic reticulum stress to the cell death program Cell Death Differ 11 372 380 1:CAS:528: DC%2BD2cXit12nur4%3D 14765132 10.1038/sj.cdd.4401378 (Pubitemid 38489415)
5. JJ Credle JS Finer-Moore FR Papa RM Stroud P Walter 2005 On the mechanism of sensing unfolded protein in the endoplasmic reticulum Proc Natl Acad Sci USA 102 18773 18784 1:CAS:528:DC%2BD28XivVyktQ%3D%3D 16365312 10.1073/pnas. 0509487102 (Pubitemid 43049523)
6. JM Chandler GM Cohen M MacFarlane 1998 Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver J Biol Chem 273 10815 10818 1:CAS:528:DyaK1cXjtFGksbY%3D 9556551 10.1074/jbc.273.18.10815 (Pubitemid 28204912)
7. T Nakagawa H Zhu N Morishima E Li J Xu BA Yankner, et al. 2000 Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta Nature 403 98 103 1:CAS:528:DC%2BD3cXlvVSqsg%3D%3D 10638761 10.1038/47513 (Pubitemid 30038529)
8. MH Taylor MR Buckwalter AC Stephenson JL Hart BJ Taylor KL O'Neill 2002 Radiation-induced apoptosis in MOLT-4 cells requires de novo protein synthesis independent of de novo RNA synthesis FEBS Lett 514 199 203 1:CAS:528: DC%2BD38Xis1ejt7w%3D 11943151 10.1016/S0014-5793(02)02364-5 (Pubitemid 34273939)
9. F Urano A Bertolotti D Ron 2000 IRE1 and efferent signaling from the endoplasmic reticulum J Cell Sci 113 3697 3702 1:CAS:528:DC%2BD3cXosVGmtLo%3D 11034898
10. H Zinszner M Kuroda X Wang N Batchvarova RT Lightfoot H Remotti, et al. 1998 CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev 12 982 995 1:CAS:528: DyaK1cXisl2gsr4%3D 9531536 10.1101/gad.12.7.982
11. MJ Arends AH Wyllie 1991 Apoptosis: mechanisms and roles in pathology Int Rev Exp Pathol 32 223 254 1:STN:280:DyaK3MzisVSqsQ%3D%3D 1677933
12. JB Kerr CM Knell M Abbott K Donachie 1987 Ultrastructural analysis of the effect of ethane dimethanesulphonate on the testis of the rat, guinea pig, hamster and mouse Cell Tissue Res 249 451 457 1:CAS:528:DyaL2sXlt1yltro%3D 3621309
13. GM Cohen XM Sun RT Snowden D Dinsdale DN Skilleter 1992 Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation Biochem J 286 331 334 1:CAS:528:DyaK38XlsV2htLY%3D 1530564
14. T Mizoroki S Meshitsuka S Maeda M Murayama N Sahara A Takashima 2007 Aluminum induces tau aggregation in vitro but not in vivo J Alzheimers Dis 11 419 427 1:CAS:528:DC%2BD2sXnvFKksL4%3D 17656819
15. S Meshitsuka DA Aremu T Nose 2002 A risk of Alzheimer's disease and aluminum in drinking water Psychogeriatrics 2 263 268 10.1111/j.1479-8301.2002. tb00039.x
16. V Rondeau H Jacqmin-Gadda D Commenges C Helmer JF Dartigues 2009 Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort Am J Epidemiol 169 489 496 19064650 10.1093/aje/kwn348
17. M Yasui Y Yase K Ota M Mukoyama K Adachi 1991 High aluminum deposition in the central nervous system of patients with amyotrophic lateral sclerosis from the Kii Peninsula, Japan: two case reports Neurotoxicology 12 277 283 1:STN:280:DyaK38%2Fms1ansg%3D%3D 1956586
18. DP Forster AJ Newens DW Kay JA Edwardson 1995 Risk factors in clinically diagnosed presenile dementia of the Alzheimer type: a case-control study in northern England J Epidemiol Community Health 49 253 258 1:STN:280: DyaK2MzlsFOqsg%3D%3D 7629459 10.1136/jech.49.3.253
19. A Campbell D Hamai SC Bondy 2001 Differential toxicity of aluminum salts in human cell lines of neural origin: implications for neurodegeneration Neurotoxicology 22 63 71 1:CAS:528:DC%2BD3MXjs1aqtL4%3D 11307852 10.1016/S0161-813X(00)00007-3 (Pubitemid 32220687)
20. SX Guo-Ross EY Yang TJ Walsh SC Bondy 1997 Decrease of glial fibrillary acidic protein in rat frontal cortex following aluminum treatment J Neurochem 73 1609 1614 10.1046/j.1471-4159.1999.0731609.x
21. KS Rao 1992 Effect of aluminium (Al) on the brain cells of the rat Biochem Int 28 51 56 1:CAS:528:DyaK38Xmt1yjtro%3D 1332724
22. C Struys-Ponsar O Guillard P van den Bosch de Aguilar 2000 Effects of aluminum exposure on glutamate metabolism: a possible explanation for its toxicity Exp Neurol 163 157 164 1:CAS:528:DC%2BD3cXislCnsLg%3D 10785454 10.1006/exnr.2000.7355 (Pubitemid 30314370)
23. GW Guo YX Liang 2001 Aluminum-induced apoptosis in cultured astrocytes and its effect on calcium homeostasis Brain Res 888 221 226 1:CAS:528: DC%2BD3MXitlyquw%3D%3D 11150478 10.1016/S0006-8993(00)03057-2 (Pubitemid 32058786)
24. DA Aremu S Meshitsuka 2005 Accumulation of aluminum by primary cultured astrocytes from aluminum amino acid complex and its apoptotic effect Brain Res 1031 284 296 1:CAS:528:DC%2BD2MXkvFaquw%3D%3D 15649454 10.1016/j.brainres.2004. 06.090 (Pubitemid 40093081)
25. MB Suarez-Fernandez AB Soldado A Sanz-Medel JA Vega A Novelli MT Fernandez-Sanchez 1999 Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death Brain Res 835 125 136 1:CAS:528:DyaK1MXktlyitb8%3D 10415367 10.1016/S0006-8993(99)01536-X (Pubitemid 29343774)
26. SH Oliet R Piet DA Poulain 2001 Control of glutamate clearance and synaptic efficacy by glial coverage of neurons Science 292 923 926 1:CAS:528:DC%2BD3MXjsVSrt7g%3D 11340204 10.1126/science.1059162 (Pubitemid 32422488)
27. R Piet DA Poulain SH Oliet 2004 Contribution of astrocytes to synaptic transmission in the rat supraoptic nucleus Neurochem Int 45 251 257 1:CAS:528:DC%2BD2cXktVOjs7Y%3D 15145540 10.1016/j.neuint.2003.07.005 (Pubitemid 38625616)
28. M Simard M Nedergaard 2004 The neurobiology of glia in the context of water and ion homeostasis Neuroscience 129 877 896 1:CAS:528:DC%2BD2cXhtVSltbbK 15561405 10.1016/j.neuroscience.2004.09.053 (Pubitemid 39556241)
29. JD Rothstein M Dykes-Hoberg CA Pardo LA Bristol L Jin RW Kuncl, et al. 1996 Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate Neuron 16 675 686 1:CAS:528:DyaK28XhvFyltrg%3D 8785064 10.1016/S0896-6273(00)80086-0 (Pubitemid 26103145)
30. DA Aremu S Meshitsuka 2006 Some aspects of astroglial functions and aluminum implications for neurodegeneration Brain Res Rev 52 193 200 1:CAS:528:DC%2BD28XntVyrtr0%3D 16529821 10.1016/j.brainresrev.2006.02.001 (Pubitemid 44051538)
31. G Smale NR Nichols DR Brady CE Finch WE Horton 1995 Evidence for apoptotic cell death in Alzheimer's disease Exp Neurol 133 225 230 1:STN:280:DyaK2MznsleltA%3D%3D 7544290 10.1006/exnr.1995.1025
32. S Meshitsuka DA Aremu 2008 (13)C Heteronuclear NMR studies of the interaction of cultured neurons and astrocytes and aluminum blockade of the preferential release of citrate from astrocytes J Biol Inorganic Chem 13 241 247 1:CAS:528:DC%2BD1cXhtV2ntLk%3D 10.1007/s00775-007-0317-8
33. S Matsuzaki T Manabe T Katayama A Nishikawa T Yanagita H Okuda, et al. 2004 Metals accelerate production of the aberrant splicing isoform of the presenilin-2 J Neurochem 88 1345 1351 1:CAS:528:DC%2BD2cXivVCit7s%3D 15009634 10.1111/j.1471-4159.2004.02290.x
34. N Sato K Imaizumi T Manabe M Taniguchi J Hitomi T Katayama, et al. 2001 Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2 J Biol Chem 276 2108 2114 1:CAS:528:DC%2BD3MXotVCmsA%3D%3D 11031265 10.1074/jbc.M006886200 (Pubitemid 32111741)
35. T Katayama K Imaizumi T Manabe J Hitomi T Kudo M Tohyama 2004 Induction of neuronal death by ER stress in Alzheimer's disease J Chem Neuroanat 28 67 78 1:CAS:528:DC%2BD2cXnsFSqsb4%3D 15363492 10.1016/j.jchemneu.2003.12.004 (Pubitemid 39198955)
36. C Reimertz D Kogel A Rami T Chittenden JH Prehn 2003 Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway J Cell Biol 162 587 597 1:CAS:528:DC%2BD3sXms1Sqtrg%3D 12913114 10.1083/jcb.200305149 (Pubitemid 37022937)
37. MR Kim EG Jeong B Chae JW Lee YH Soung SW Nam, et al. 2007 Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas Dig Dis Sci 52 2751 2756 1:CAS:528:DC%2BD2sXhtVSisLrK 17393317 10.1007/s10620-007-9799-z (Pubitemid 47373931)
38. RK Reddy C Mao P Baumeister RC Austin RJ Kaufman AS Lee 2003 Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation J Biol Chem 278 20915 20924 1:CAS:528:DC%2BD3sXkt1Wisb8%3D 12665508 10.1074/jbc.M212328200 (Pubitemid 36806399)
39. JM Jurgensmeier Z Xie Q Deveraux L Ellerby D Bredesen JC Reed 1998 Bax directly induces release of cytochrome c from isolated mitochondria Proc Natl Acad Sci USA 95 4997 5002 1:CAS:528:DyaK1cXivV2jsrc%3D 9560217 10.1073/pnas.95.9.4997 (Pubitemid 28208539)
40. J Yang X Liu K Bhalla CN Kim AM Ibrado J Cai, et al. 1997 Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked Science 275 1129 1132 1:CAS:528:DyaK2sXhtlKjs70%3D 9027314 10.1126/science.275.5303.1129 (Pubitemid 27097312)
41. JR Jeffers E Parganas Y Lee C Yang J Wang J Brennan, et al. 2003 PUMA is an essential mediator of p53-dependent and -independent apoptotic pathways Cancer Cell 4 321 328 1:CAS:528:DC%2BD3sXoslequrc%3D 14585359 10.1016/S1535-6108(03)00244-7 (Pubitemid 37329796)
42. T Okada H Yoshida R Akazawa M Negishi K Mori 2002 Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response Biochem J 366 585 594 1:CAS:528:DC%2BD38XnvFGltb0%3D 12014989 10.1042/BJ20020391 (Pubitemid 35001703)
43. W Tirasophon AA Welihinda RJ Kaufman 1998 A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells Genes Dev 2 1812 1824 10.1101/gad.12.12.1812
44. XZ Wang HP Harding Y Zhang EM Jolicoeur M Kuroda D Ron 1998 Cloning of mammalian Ire1 reveals diversity in the ER stress responses EMBO J 17 5708 5717 1:CAS:528:DyaK1cXmvVyjsLo%3D 9755171 10.1093/emboj/17.19.5708 (Pubitemid 28445982)
45. K Lee W Tirasophon X Shen M Michalak R Prywes T Okada, et al. 2002 IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response Genes Dev 16 452 466 1:CAS:528:DC%2BD38XhvFKgs7s%3D 11850408 10.1101/gad.964702 (Pubitemid 34165102)
46. DE Dimcheff MA Faasse FJ McAtee JL Portis 2004 Endoplasmic reticulum (ER) stress induced by a neurovirulent mouse retrovirus is associated with prolonged BiP binding and retention of a viral protein in the ER J Biol Chem 279 33782 33790 1:CAS:528:DC%2BD2cXmtFOiu7s%3D 15178688 10.1074/jbc.M403304200 (Pubitemid 39063027)
47. A Bertolotti Y Zhang LM Hendershot HP Harding D Ron 2002 Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response Nat Cell Biol 2 326 332
48. RJ Kaufman 2002 Orchestrating the unfolded protein response in health and disease J Clin Invest 110 1389 1398 1:CAS:528:DC%2BD38XovFOnurc%3D 12438434
49. J Shen X Chen L Hendershot R Prywes 2002 ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals Dev Cell 3 99 111 1:CAS:528:DC%2BD38XlsFSmsL8%3D 12110171 10.1016/S1534-5807(02)00203-4 (Pubitemid 34778399)
50. DT Rutkowski RJ Kaufman 2004 A trip to the ER: coping with stress Trends Cell Biol 14 20 28 1:CAS:528:DC%2BD2cXjtFegsw%3D%3D 14729177 10.1016/j.tcb.2003.11.001 (Pubitemid 38076857)
51. J Groenendyk M Michalak 2005 Endoplasmic reticulum quality control and apoptosis Acta Biochim Pol 52 381 395 1:CAS:528:DC%2BD2MXhtFWisbbP 15933766 (Pubitemid 41133773)
52. 2+ signaling and calcium binding chaperones of the endoplasmic reticulum Cell Calcium 32 269 278 1:CAS:528:DC%2BD3sXhtFKntbw%3D 12543089 10.1016/S0143416002001884 (Pubitemid 36175750)
53. M Michalak EF Corbett N Mesaeli K Nakamura M Opas 1999 Calreticulin: one protein, one gene, many functions Biochem J 344 281 292 1:CAS:528:DC%2BD3cXltFCk 10567207 10.1042/0264-6021:3440281 (Pubitemid 30011581)
54. Y Saito Y Ihara MR Leach MF Cohen-Doyle DB Williams 1999 Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins EMBO J 18 6718 6729 1:CAS:528:DC%2BD3cXhslOquw%3D%3D 10581245 10.1093/emboj/18.23.6718
55. A Zuppini J Groenendyk LA Cormack G Shore M Opas RC Bleackley, et al. 2002 Calnexin deficiency and endoplasmic reticulum stress-induced apoptosis Biochemistry 41 2850 2858 1:CAS:528:DC%2BD38Xnt1Gluw%3D%3D 11851433 10.1021/bi015967+ (Pubitemid 34168955)
56. MJ Gething 1999 Role and regulation of the ER chaperone BiP Semin Cell Dev Biol 10 465 472 1:CAS:528:DyaK1MXnvFOmsLs%3D 10597629 10.1006/scdb.1999.0318 (Pubitemid 129513234)
57. OF Ezomo F Matsushima S Meshitsuka 2009 Up-regulation in the expression of renin gene by the influence of aluminium J Inorg Biochem 103 1563 1570 1:CAS:528:DC%2BD1MXhtlWis7zK 19735944 10.1016/j.jinorgbio.2009.07.018
58. A Butkus PJ Roche RT Fernley J Haralambidis JD Penschow GB Ryan, et al. 1987 Purification and cloning of a corpuscles of Stannius protein from Anguilla australis Mol Cell Endocrinol 54 123 133 1:CAS:528:DyaL1cXhs1ansrg%3D 3319739 10.1016/0303-7207(87)90149-3 (Pubitemid 18015598)
59. AC Chang RR Reddel 1998 Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2 Mol Cell Endocrinol 141 95 99 1:CAS:528:DyaK1cXltlKru74%3D 9723890 10.1016/S0303-7207(98)00097-5 (Pubitemid 28393383)
60. K Ishibashi M Imai 2002 Prospect of a stanniocalcin endocrine/paracrine system in mammals Am J Physiol Renal Physiol 282 F367 F375 1:CAS:528: DC%2BD38Xit1Ggt74%3D 11832417
61. D Ito JR Walker CS Thompson I Moroz W Lin ML Veselits, et al. 2004 Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties Mol Cell Biol 24 9456 9459 1:CAS:528:DC%2BD2MXltl2isw%3D%3D 15485913 10.1128/MCB.24.21.9456-9469.2004 (Pubitemid 39391682)
62. T Murakami S Kondo M Ogata S Kanemoto A Saito A Wanaka, et al. 2006 Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress J Neurochem 96 1090 1100 1:CAS:528: DC%2BD28XivFWjsrc%3D 16417584 10.1111/j.1471-4159.2005.03596.x
63. S Kondo T Murakami K Tatsumi M Ogata S Kanemoto K Otori, et al. 2005 OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes Nat Cell Biol 7 186 194 1:CAS:528:DC%2BD2MXpt1CjsQ%3D%3D 15665855 10.1038/ncb1213 (Pubitemid 40268134)
64. RW Carrell DA Lomas 1997 Conformational disease Lancet 350 134 138 1:CAS:528:DyaK2sXkvFeis7s%3D 9228977 10.1016/S0140-6736(97)02073-4 (Pubitemid 27313650)
65. J Hardy DJ Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353 356 1:CAS:528:DC%2BD38Xls1Cju7s%3D 12130773 10.1126/science.1072994 (Pubitemid 34790756)
66. DJ Selkoe 1997 Alzheimer's disease: genotypes, phenotypes, and treatments Science 275 630 631 1:CAS:528:DyaK2sXptVOmug%3D%3D 9019820 10.1126/science.275. 5300.630 (Pubitemid 27061322)
67. Q Zhang ET Powers J Nieva ME Huff MA Dendle J Bieschke, et al. 2004 Metabolite-initiated protein misfolding may trigger Alzheimer's disease Proc Natl Acad Sci USA 101 4752 4757 1:CAS:528:DC%2BD2cXjsFCjtbs%3D 15034169 10.1073/pnas.0400924101 (Pubitemid 38469149)
68. T Hoshino T Nakaya W Araki K Suzuki T Suzuki T Mizushima 2007 Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides Biochem J 402 581 589 1:CAS:528:DC%2BD2sXitVKhtrg%3D 17132139 10.1042/BJ20061318 (Pubitemid 46423895)
69. Y Imai M Soda S Hatakeyama T Akagi T Hashikawa KI Nakayama, et al. 2002 CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity Mol Cell 10 55 67 1:CAS:528:DC%2BD38XmtFaktLY%3D 12150907 10.1016/S1097-2765(02)00583-X (Pubitemid 34876562)
70. H Nishitoh A Matsuzawa K Tobiume K Saegusa K Takeda K Inoue, et al. 2002 ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats Genes Dev 16 1345 1355 1:CAS:528:DC%2BD38XkslWhtLo%3D 12050113 10.1101/gad.992302 (Pubitemid 34615088)
71. F Terro C Czech F Esclaire W Elyaman C Yardin MC Baclet, et al. 2002 Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress J Neurosci Res 69 530 539 1:CAS:528:DC%2BD38XmtVOgsro%3D 12210846 10.1002/jnr.10312 (Pubitemid 34831413)
72. S Tobisawa Y Hozumi S Arawaka S Koyama M Wada M Nagai, et al. 2003 Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice Biochem Biophys Res Commun 303 496 503 1:CAS:528:DC%2BD3sXitlWhtrs%3D 12659845 10.1016/S0006-291X(03)00353- X (Pubitemid 36349197)