Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels

Brain Research

Volumn 1369, Issue , 2011, Pages 21-35

  Lee, Moonhee ^a   Jantaratnotai, Nattinee ^a   McGeer, Edith ^a   McLarnon, James G ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer disease; Ca 2+ channels; Neuroinflammation; Neurotoxicity; P2X7 receptors; P2Y receptors; Parkinson disease

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MAGNESIUM ION; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; PURINERGIC RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; URIDINE TRIPHOSPHATE; CALCIUM; ION; MAGNESIUM; PURINERGIC P2 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROGLIA; NEUROTOXICITY; PRIORITY JOURNAL; TISSUE CULTURE; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; INFLAMMATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CALCIUM; CELL LINE; HUMANS; INFLAMMATION; INTERLEUKIN-6; IONS; MAGNESIUM; MICROGLIA; PURINERGIC AGONISTS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; RECEPTORS, PURINERGIC P2Y2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78651108146     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.10.084     Document Type: Article

References (59)

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